Lack of Chromatin and Nuclear Fragmentation In Vivo Impairs the
... Lorenza Frisoni,* Lenese McPhie,* Sun-Ah Kang,† Marc Monestier,† Michael Madaio,† Minoru Satoh,‡ and Roberto Caricchio2* ...
... Lorenza Frisoni,* Lenese McPhie,* Sun-Ah Kang,† Marc Monestier,† Michael Madaio,† Minoru Satoh,‡ and Roberto Caricchio2* ...
In immunology, an adjuvant is an agent that may stimulate the
... develop in the mosquito's salivary glands, leave the mosquito during a blood meal, and enter the liver where they multiply. Cells infected with sporozoites eventually burst, releasing merozoites into the bloodstream A merozoite (G. meros, part [of a series], +zoon, animal) are the result of merogony ...
... develop in the mosquito's salivary glands, leave the mosquito during a blood meal, and enter the liver where they multiply. Cells infected with sporozoites eventually burst, releasing merozoites into the bloodstream A merozoite (G. meros, part [of a series], +zoon, animal) are the result of merogony ...
Tartrate‐Resistant Acid Phosphatase Deficiency in the
... patients also manifest a variable neurologic and autoimmune phenotype. These autoimmune features include antinuclear antibody (ANA) and anti–double-stranded DNA (anti-dsDNA) antibody, autoimmune thrombocytopenic purpura, and systemic lupus erythematosus (SLE). Patients with SPENCD consistently show ...
... patients also manifest a variable neurologic and autoimmune phenotype. These autoimmune features include antinuclear antibody (ANA) and anti–double-stranded DNA (anti-dsDNA) antibody, autoimmune thrombocytopenic purpura, and systemic lupus erythematosus (SLE). Patients with SPENCD consistently show ...
prolactin and autoimmune diseases prolakt
... T-cells, B-cells, macrophages, and natural killer cells. The pioneering experiments of Nagy and Berczi (32, 33) demonstrated the importance of prolactin in maintaining normal immune function and sustaining life. Hypophysectomized rats had reduced dinitrochlorobenzene-induced dermatitis and suppresse ...
... T-cells, B-cells, macrophages, and natural killer cells. The pioneering experiments of Nagy and Berczi (32, 33) demonstrated the importance of prolactin in maintaining normal immune function and sustaining life. Hypophysectomized rats had reduced dinitrochlorobenzene-induced dermatitis and suppresse ...
Immunoflourescence in dermatopathology
... The best site and evolution time of skin lesions to perform biopsy for direct immunofluorescence examination (DIF) depend on the disease under investigation. Generally, the biopsy should have an appropriate extension (4 mm punch) and depth that involves both the epidermis and dermis in sufficient pr ...
... The best site and evolution time of skin lesions to perform biopsy for direct immunofluorescence examination (DIF) depend on the disease under investigation. Generally, the biopsy should have an appropriate extension (4 mm punch) and depth that involves both the epidermis and dermis in sufficient pr ...
Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins
... disease activity index; SS, primary Sjögren’s syndrome ...
... disease activity index; SS, primary Sjögren’s syndrome ...
Dooley MA.Clinical and laboratory features of lupus nephritis
... Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE). The true prevalence of clinical lupus nephritis in persons with SLE is probably around 50%, being higher in certain ethnic groups and in children. It was hypothesized that intrarenal B cells form par ...
... Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE). The true prevalence of clinical lupus nephritis in persons with SLE is probably around 50%, being higher in certain ethnic groups and in children. It was hypothesized that intrarenal B cells form par ...
The importance of the type I interferon system in autoimmunity
... increased apoptosis and reduced clearance of apoptotic cells in lupus (16). Recent studies have shown that neutrophils undergoing so called NETosis also have the capacity to provide intererferogenic autoantigens (17), demonstrating that several pathways can lead to pDC activation. In 2003 several re ...
... increased apoptosis and reduced clearance of apoptotic cells in lupus (16). Recent studies have shown that neutrophils undergoing so called NETosis also have the capacity to provide intererferogenic autoantigens (17), demonstrating that several pathways can lead to pDC activation. In 2003 several re ...
Chromatin as a target antigen in human and murine lupus nephritis
... the context of Wegener’s granulomatosis [48]. In situ deposition of chromatin fragments has been described in several experimental nuclease deficiencies on nonautoimmune backgrounds (reviewed in [49]). In contrast to the correlation of renal DNaseI shutdown, Martinez-Valle and colleagues did not obse ...
... the context of Wegener’s granulomatosis [48]. In situ deposition of chromatin fragments has been described in several experimental nuclease deficiencies on nonautoimmune backgrounds (reviewed in [49]). In contrast to the correlation of renal DNaseI shutdown, Martinez-Valle and colleagues did not obse ...
yahar
... Hashimoto's thyroiditis: consistently increased serum levels of thyroxin myasthenia gravis: easy fatigability of muscles Grave's disease: anti-thyroid stimulating immunoglobulins pernicious anemia: degeneration of spinal dorsal and lateral tracts Goodpasture syndrome: anti-basement membrane antibody ...
... Hashimoto's thyroiditis: consistently increased serum levels of thyroxin myasthenia gravis: easy fatigability of muscles Grave's disease: anti-thyroid stimulating immunoglobulins pernicious anemia: degeneration of spinal dorsal and lateral tracts Goodpasture syndrome: anti-basement membrane antibody ...
Novel approaches to the development of targeted therapeutic
... study included 227 patients with a moderate to severe lupus disease activity without active renal or central nervous system involvement (mean BILAG and SLEDAI scores of 15.2 and 14.8, respectively). Treatment with Epratuzumab 2400 mg cumulative dose was well tolerated and associated with improvement ...
... study included 227 patients with a moderate to severe lupus disease activity without active renal or central nervous system involvement (mean BILAG and SLEDAI scores of 15.2 and 14.8, respectively). Treatment with Epratuzumab 2400 mg cumulative dose was well tolerated and associated with improvement ...
clin exp rheum 27/1 - Clinical and Experimental Rheumatology
... drive a variety of reactions that may involve hematopoietic tissue and peripheral blood cells. Thus, hematologic abnormalities affecting one or more cellular lineages are common in ACTDs, and may also represent a prognostic variable, reflecting the autoimmune/inflammatory activation. In this regard, s ...
... drive a variety of reactions that may involve hematopoietic tissue and peripheral blood cells. Thus, hematologic abnormalities affecting one or more cellular lineages are common in ACTDs, and may also represent a prognostic variable, reflecting the autoimmune/inflammatory activation. In this regard, s ...
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... are known to be central in autoantibody production amplification during the disease course. A breakthrough in the study of SLE pathogenesis was the discovery of B-cell activating factor (BAFF), a B-survival factor produced by myeloid cells (monocytes, macrophages, neutrophils and dendritic cells) an ...
... are known to be central in autoantibody production amplification during the disease course. A breakthrough in the study of SLE pathogenesis was the discovery of B-cell activating factor (BAFF), a B-survival factor produced by myeloid cells (monocytes, macrophages, neutrophils and dendritic cells) an ...
The role of microRNA-1246 in the regulation of B cell activation and
... Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease which affects multiple organ systems and causes significant morbidity and mortality [1]. One of the hallmarks of SLE is the production of anti-nuclear autoantibodies by uncontrolled over-activated B cells [2]. The au ...
... Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease which affects multiple organ systems and causes significant morbidity and mortality [1]. One of the hallmarks of SLE is the production of anti-nuclear autoantibodies by uncontrolled over-activated B cells [2]. The au ...
Novel pebbles in the mosaic of autoimmunity Open Access Carlo Perricone
... antibodies against self-reactive or cross-reactive DNA coengage antigen receptors and TLRs, leading to a continuous activation of these auto-reactive B cells and the development of autoimmune disease [12]. Nonetheless, environmental factors are still central to autoimmunity [13]. Indeed, it is possi ...
... antibodies against self-reactive or cross-reactive DNA coengage antigen receptors and TLRs, leading to a continuous activation of these auto-reactive B cells and the development of autoimmune disease [12]. Nonetheless, environmental factors are still central to autoimmunity [13]. Indeed, it is possi ...
Altered frequency and migration capacity of CD4
... peripheral blood from patients with SLE Frequency of Tregs in PBMCs from 20 patients with SLE, 20 patients with RA and 21 age- and sex-matched healthy controls was evaluated by flow cytometry. As shown in Fig. 1A, patients with SLE had statistically significantly decreased absolute number of Tregs ( ...
... peripheral blood from patients with SLE Frequency of Tregs in PBMCs from 20 patients with SLE, 20 patients with RA and 21 age- and sex-matched healthy controls was evaluated by flow cytometry. As shown in Fig. 1A, patients with SLE had statistically significantly decreased absolute number of Tregs ( ...
Z-DNA-specific Antibodies in Human Systemic
... Evidence from competitive radioimmunoassay indicates that there are two types of Z-DNA reactive antibodies. One type, which is retained on a dDNA affinity column, is reactive with both dDNA and ZDNA since the binding of ['H]Z-DNA is competed for by both Z-DNA and dDNA. This type of antibody probably ...
... Evidence from competitive radioimmunoassay indicates that there are two types of Z-DNA reactive antibodies. One type, which is retained on a dDNA affinity column, is reactive with both dDNA and ZDNA since the binding of ['H]Z-DNA is competed for by both Z-DNA and dDNA. This type of antibody probably ...
Antinuclear Antibodies (ANA)
... positive ANA can also be seen in juvenile arthritis. Fast facts A positive ANA test means autoantibodies are present. By itself, a positive ANA test does not indicate the presence of an autoimmune disease or the need for therapy. Autoimmune diseases can be treated. What is an antibody or ANA? Antibo ...
... positive ANA can also be seen in juvenile arthritis. Fast facts A positive ANA test means autoantibodies are present. By itself, a positive ANA test does not indicate the presence of an autoimmune disease or the need for therapy. Autoimmune diseases can be treated. What is an antibody or ANA? Antibo ...
Sex-based differences in autoimmune diseases
... function, some of them are reported to play a role in immunity or autoimmunity [22, 23]. The presence of a second X chromosome in females can affect miRNA expression levels and this may be crucial for the development of female biased-autoimmunity. Interestingly, E2 can regulate miRNA expression in d ...
... function, some of them are reported to play a role in immunity or autoimmunity [22, 23]. The presence of a second X chromosome in females can affect miRNA expression levels and this may be crucial for the development of female biased-autoimmunity. Interestingly, E2 can regulate miRNA expression in d ...
Pathophysiology and Clinical Spectrum of Infections in Systemic
... Systemic lupus erythematosus (SLE) is an inflammatory and multisystemic autoimmune disorder characterized by an uncontrolled autoreactivity of B and T lymphocytes leading to the production of autoantibodies (auto-Abs) against self-directed antigens and tissue destruction. The breakdown of tolerance, ...
... Systemic lupus erythematosus (SLE) is an inflammatory and multisystemic autoimmune disorder characterized by an uncontrolled autoreactivity of B and T lymphocytes leading to the production of autoantibodies (auto-Abs) against self-directed antigens and tissue destruction. The breakdown of tolerance, ...
A Introduction
... own constituents parts as its self, which result in an immune response against its own tissues and cells. Autoimmune diseases are the disorders in which the body’s immune system reacts against its own tissues and form autoantibodies which attack its own antigens. Paul Ehrlich at the beginning of the ...
... own constituents parts as its self, which result in an immune response against its own tissues and cells. Autoimmune diseases are the disorders in which the body’s immune system reacts against its own tissues and form autoantibodies which attack its own antigens. Paul Ehrlich at the beginning of the ...
Pathomechanisms for Cytopenia in Active SLE
... Cytopenia in SLE • Pathogenic auto-antibodies , and immune complexes bind to target tissues with activation of complement and phagocytic cells. • Complement, and immune cells lead to release of chemotaxins, cytokines, chemokines, vasoactive peptides, and destructive enzymes. ...
... Cytopenia in SLE • Pathogenic auto-antibodies , and immune complexes bind to target tissues with activation of complement and phagocytic cells. • Complement, and immune cells lead to release of chemotaxins, cytokines, chemokines, vasoactive peptides, and destructive enzymes. ...
The Cellular Basis of the Impaired Autologous Mixed Lymphocyte
... an increased number of monocytes. Although mononuclear cell preparations from patients with SLE have increased numbers of monocytes which may decrease mitogen-induced T-cell proliferation (8), in our studies lymphocyte preparations were depleted of monocytes. Antilymphocyte antibodies or immune comp ...
... an increased number of monocytes. Although mononuclear cell preparations from patients with SLE have increased numbers of monocytes which may decrease mitogen-induced T-cell proliferation (8), in our studies lymphocyte preparations were depleted of monocytes. Antilymphocyte antibodies or immune comp ...
Targeting of the immune system in systemic lupus erythematosus
... transcription factor gene Irf5 are associated with SLE in humans, indicating the importance of this pathway in disease (Ref. 23). One important mechanism by which TLR ligation might contribute to SLE pathogenesis is by induction of type I IFNs. IFN-a is overexpressed in human SLE patients and accele ...
... transcription factor gene Irf5 are associated with SLE in humans, indicating the importance of this pathway in disease (Ref. 23). One important mechanism by which TLR ligation might contribute to SLE pathogenesis is by induction of type I IFNs. IFN-a is overexpressed in human SLE patients and accele ...
Systemic lupus erythematosus
Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions.The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation.There is no cure for SLE. It is mainly treated with immunosuppressants such as cyclophosphamide and corticosteroids, the goal of which is to keep symptoms under control. SLE can be fatal. The leading cause of death is from cardiovascular disease due to accelerated atherosclerosis. Life expectancy has improved over the decades. The 10-year survival rate is 92–95% and is close to that of people without lupus. This is due in part to better treatments, but also to identification of milder cases.Global prevalence varies from 20 to 70 per 100,000. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of African-American or Caribbean descent. Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity. Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by a wolf's bite. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)