Rheumatology
... Cyclophosphamide, may be needed when response to steroids is inadequate to improve renal disease or the disease is aggressive. Hydroxychloroquine is the safest drug for SLE. – However, rarely, it may cause serious eye disease including retinopathy like macular degeneration; corneal damage may also o ...
... Cyclophosphamide, may be needed when response to steroids is inadequate to improve renal disease or the disease is aggressive. Hydroxychloroquine is the safest drug for SLE. – However, rarely, it may cause serious eye disease including retinopathy like macular degeneration; corneal damage may also o ...
Lipids rule: resetting lipid metabolism restores T cell function in
... the glycosphingolipids (GSLs), is severely perturbed in the membranes of T cells from SLE patients. Furthermore, normalization of GSLs restored TCR signaling and ameliorated T cell dysfunction. These data suggest that targeting host metabolism may be an effective means of reinforcing selftolerance a ...
... the glycosphingolipids (GSLs), is severely perturbed in the membranes of T cells from SLE patients. Furthermore, normalization of GSLs restored TCR signaling and ameliorated T cell dysfunction. These data suggest that targeting host metabolism may be an effective means of reinforcing selftolerance a ...
Natural Medicine and Nutritional Therapy as an Alternative
... Systemic criteria Arthritis (inflammation of two peripheral joints with tenderness, swelling or fluid) Serositis (inflammation of the lining of the lung (also called pleura) or the heart (also called the pericardium)) Kidney disorder (protein in urine samples or abnormal sediment in urine seen under ...
... Systemic criteria Arthritis (inflammation of two peripheral joints with tenderness, swelling or fluid) Serositis (inflammation of the lining of the lung (also called pleura) or the heart (also called the pericardium)) Kidney disorder (protein in urine samples or abnormal sediment in urine seen under ...
Autoimmunity
... mimicry. For example, infections by the Epstein-Barr virus (EBV) have been associated with multiple sclerosis (MS). A. Many people are subject to infections by EBV but a relatively small percentage of these develop an autoimmune disease. Why? B. Mis-recognition of antigens more commonly involves the ...
... mimicry. For example, infections by the Epstein-Barr virus (EBV) have been associated with multiple sclerosis (MS). A. Many people are subject to infections by EBV but a relatively small percentage of these develop an autoimmune disease. Why? B. Mis-recognition of antigens more commonly involves the ...
Elisa kits Manual
... lupus erythematosus (SLE), appear to play a central role in the pathogenesis of tissue injury and are closely correlated with clinical activity. Their presence is also associated with active lupus and usually with immune complex glomerulo-nephritis. Antibodies to ds-DNA are directed against the phos ...
... lupus erythematosus (SLE), appear to play a central role in the pathogenesis of tissue injury and are closely correlated with clinical activity. Their presence is also associated with active lupus and usually with immune complex glomerulo-nephritis. Antibodies to ds-DNA are directed against the phos ...
Tolerance - BHS116.3 Physiology III
... Aims • Review mechanisms of T cell tolerance. • Describe the factors involved in the breakdown of tolerance. • Define autoimmunity. • Describe autoimmune diseases, concentrating on the role of immunity in their pathogenesis. • Readings: Robbins, Chapter 5 ...
... Aims • Review mechanisms of T cell tolerance. • Describe the factors involved in the breakdown of tolerance. • Define autoimmunity. • Describe autoimmune diseases, concentrating on the role of immunity in their pathogenesis. • Readings: Robbins, Chapter 5 ...
- Dr. Robert Fox
... Time course of autoimmune response* 1. Genetic factors predispose to Sjogren’s. 2. Environmental factors such as a viral infection may lead to formation of autoantibodies. 3. Antibodies precede disease (however, presence of antibody does not ...
... Time course of autoimmune response* 1. Genetic factors predispose to Sjogren’s. 2. Environmental factors such as a viral infection may lead to formation of autoantibodies. 3. Antibodies precede disease (however, presence of antibody does not ...
Allergy and Immune Disorders
... Believed to be caused by antibodies that fight the body’s own cells and tissues that it normally protects leading to inflammation and tissue/organ damage Exacerbations caused by pregnancy and BCP use are d/t increase in estrogen S/S-waxes and waning symptoms such as fatigue, fever, weight loss ...
... Believed to be caused by antibodies that fight the body’s own cells and tissues that it normally protects leading to inflammation and tissue/organ damage Exacerbations caused by pregnancy and BCP use are d/t increase in estrogen S/S-waxes and waning symptoms such as fatigue, fever, weight loss ...
Rheumatoid Arthritis
... In 2003, the total cost of arthritis was $128 billion—nearly $81 billion in direct costs and $47 billion in indirect costs, equal to 1.2% of the 2003 U.S. gross domestic product. Arthritis is not just an old person’s disease. Nearly two-thirds of people with arthritis are younger than 65. Although a ...
... In 2003, the total cost of arthritis was $128 billion—nearly $81 billion in direct costs and $47 billion in indirect costs, equal to 1.2% of the 2003 U.S. gross domestic product. Arthritis is not just an old person’s disease. Nearly two-thirds of people with arthritis are younger than 65. Although a ...
The role of apoptosis in systemic lupus erythematosus
... Too much apoptosis? In fact, far from being a disease of too little apoptosis, the evidence has been available for a long time that SLE is quite the opposite. Under normal physiological circumstances, apoptotic cells are cleared very effectively by phagocytes [10, 23]. If this were not the case, we ...
... Too much apoptosis? In fact, far from being a disease of too little apoptosis, the evidence has been available for a long time that SLE is quite the opposite. Under normal physiological circumstances, apoptotic cells are cleared very effectively by phagocytes [10, 23]. If this were not the case, we ...
Lecture 2 - Autoimmune diseases
... Rheumatoid Arthritis (Contd.) • The cause of rheumatoid arthritis is not known – Investigating possibilities of a foreign antigen, such as a virus • Both prevalence and incidence are 2-3 times greater in women than in men ...
... Rheumatoid Arthritis (Contd.) • The cause of rheumatoid arthritis is not known – Investigating possibilities of a foreign antigen, such as a virus • Both prevalence and incidence are 2-3 times greater in women than in men ...
Q1. What is lupus? Q2. What are the organs and tissues most
... B. Skin Problems. Most patients with lupus develop skin rashes, and these are often an important clue to the diagnosis of lupus. The classic rash is a butterfly rash over the cheeks and bridge of the ...
... B. Skin Problems. Most patients with lupus develop skin rashes, and these are often an important clue to the diagnosis of lupus. The classic rash is a butterfly rash over the cheeks and bridge of the ...
hypersensitivity - immunology.unideb.hu
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmers lung’ and ‘piegeon-breeder’s lung’ ...
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmers lung’ and ‘piegeon-breeder’s lung’ ...
Major functions of the immune system
... Describe the guidelines for universal precautions and infection control. Explain the destructive mechanisms in autoimmune diseases. SLE, RA Describe the symptoms and signs of pernicious anemia. Name the primary treatment. Describe the pathology and diagnostic criteria. ...
... Describe the guidelines for universal precautions and infection control. Explain the destructive mechanisms in autoimmune diseases. SLE, RA Describe the symptoms and signs of pernicious anemia. Name the primary treatment. Describe the pathology and diagnostic criteria. ...
10th practice 2012
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmers lung’ and ‘piegeon-breeder’s lung’ ...
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmers lung’ and ‘piegeon-breeder’s lung’ ...
10. practice 2011
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmer lung’ and ‘piegeon breeder lung’ ...
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmer lung’ and ‘piegeon breeder lung’ ...
Systemic Lupus Erythematosus - UC Irvine`s Department of Medicine
... either early onset of menarche (age ≤ 10 years) or administration of estrogen to postmenopausal women doubles their risk Treatment of clinically stable SLE with oral contraceptives for one year does not increase disease flares ...
... either early onset of menarche (age ≤ 10 years) or administration of estrogen to postmenopausal women doubles their risk Treatment of clinically stable SLE with oral contraceptives for one year does not increase disease flares ...
- Dr. Robert Fox
... with Type 1 IFN production. • As noted above, also find a homing receptor (CXCR5) which goes with the tissue-specific homing receptors. • In SS patients with lymphoma, find A20 (member of TNF superfamily) that suppresses NFK-b and B-cell ...
... with Type 1 IFN production. • As noted above, also find a homing receptor (CXCR5) which goes with the tissue-specific homing receptors. • In SS patients with lymphoma, find A20 (member of TNF superfamily) that suppresses NFK-b and B-cell ...
misdirected reactions of the immune system autoimmunity
... SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) * Effector mechanisms • Autoantibodies to many autoantigens • Most common autoantibody is to ds-DNA • Immune complex deposition on basement membranes with complement activation and inflammation ...
... SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) * Effector mechanisms • Autoantibodies to many autoantigens • Most common autoantibody is to ds-DNA • Immune complex deposition on basement membranes with complement activation and inflammation ...
treating autoimmune diseases with homeopathy
... The white blood cells in the body’s immune system help protect against harmful substances. Examples include bacteria, viruses, toxins, cancer cells, and blood and tissue from outside the body. These substances contain antigens. The immune system produces antibodies against these antigens that enable ...
... The white blood cells in the body’s immune system help protect against harmful substances. Examples include bacteria, viruses, toxins, cancer cells, and blood and tissue from outside the body. These substances contain antigens. The immune system produces antibodies against these antigens that enable ...
1. Systemic autoimmune disease
... Rheumatoid Arthritis (RA) is characterised by persistent inflammation of the synovium leading to varying degrees of joint destruction. The disease is associated with HLA-DR4 and HLA-DR1 and occurs more frequently in women. The target autoantigen is unknown, although type II collagen is a candidate. ...
... Rheumatoid Arthritis (RA) is characterised by persistent inflammation of the synovium leading to varying degrees of joint destruction. The disease is associated with HLA-DR4 and HLA-DR1 and occurs more frequently in women. The target autoantigen is unknown, although type II collagen is a candidate. ...
Autoimmunity and Autoimmune Diseases
... – antiCD20 antibody (targeting B-cell) for the treatment of rheumatoid arthritis – Anti-IL6 receptor antibody treatment in rheumatoid arthritis – Beta interferon for the treatment of multiple sclerosis – Anti-type I interferons for the treatment of systemic lupus erythematosus (in development) – Man ...
... – antiCD20 antibody (targeting B-cell) for the treatment of rheumatoid arthritis – Anti-IL6 receptor antibody treatment in rheumatoid arthritis – Beta interferon for the treatment of multiple sclerosis – Anti-type I interferons for the treatment of systemic lupus erythematosus (in development) – Man ...
Systemic lupus erythematosus
Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions.The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation.There is no cure for SLE. It is mainly treated with immunosuppressants such as cyclophosphamide and corticosteroids, the goal of which is to keep symptoms under control. SLE can be fatal. The leading cause of death is from cardiovascular disease due to accelerated atherosclerosis. Life expectancy has improved over the decades. The 10-year survival rate is 92–95% and is close to that of people without lupus. This is due in part to better treatments, but also to identification of milder cases.Global prevalence varies from 20 to 70 per 100,000. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of African-American or Caribbean descent. Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity. Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by a wolf's bite. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)