(SLE).
... - increased levels of type I IFN–induced genes in lupus PBMCs (MX1, the OAS family, and IFIT1) - both type I IFNs and type II IFN (IFN-γ) • fluctuation of IFN levels in individual patients - ELISA platforms for measuring IFN-α have not been useful - fluctuations in IFN-inducible gene expression in P ...
... - increased levels of type I IFN–induced genes in lupus PBMCs (MX1, the OAS family, and IFIT1) - both type I IFNs and type II IFN (IFN-γ) • fluctuation of IFN levels in individual patients - ELISA platforms for measuring IFN-α have not been useful - fluctuations in IFN-inducible gene expression in P ...
Autoimmune Diseases
... • During acute exacerbations, plasmapheresis may be used • SLE clients are carefully monitored for renal, cardiac, pulmonary, hematological and ...
... • During acute exacerbations, plasmapheresis may be used • SLE clients are carefully monitored for renal, cardiac, pulmonary, hematological and ...
To the principal Azra naheed Medical college Lahore
... . Examples : Hey fever, Asthma, Anaphylaxis ...
... . Examples : Hey fever, Asthma, Anaphylaxis ...
Benlysta(belimumab)
... • is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. It is a Type III hypersensitivity reaction ca ...
... • is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. It is a Type III hypersensitivity reaction ca ...
PowerPoint Presentation - Atypical Cutaneous Leishmaniasis
... SLE (Lupus) 10:1 female:male Humans with SLE have increased estrogen Mouse/humans -lupus during pregnancy Mouse models-difference in estrogen receptors ...
... SLE (Lupus) 10:1 female:male Humans with SLE have increased estrogen Mouse/humans -lupus during pregnancy Mouse models-difference in estrogen receptors ...
lups net ppt 2
... -> Spontaneously develop a systemic autoimmune disease similar to lupus -> autoantibodies, immune complex disease, premature death -> Parental NZB mice have milder for of disease -> Useful model for dissecting the complex genetics of the disease -> multigenic, with different genes controlling differ ...
... -> Spontaneously develop a systemic autoimmune disease similar to lupus -> autoantibodies, immune complex disease, premature death -> Parental NZB mice have milder for of disease -> Useful model for dissecting the complex genetics of the disease -> multigenic, with different genes controlling differ ...
Autoimmune Diseases
... Autoimmune disorders are caused by the immune system attacking healthy cells in the body Examples of rheumatoid arthritis, multiple sclerosis, type 1diabetes, vitiligo and systemic lupus erythematosus MiRNA’s are able to repress targeted gene expression by interfering with translation of mRNA or deg ...
... Autoimmune disorders are caused by the immune system attacking healthy cells in the body Examples of rheumatoid arthritis, multiple sclerosis, type 1diabetes, vitiligo and systemic lupus erythematosus MiRNA’s are able to repress targeted gene expression by interfering with translation of mRNA or deg ...
lupus ppt for website
... butterfly shaped rash on cheek and nose, sun or light sensitivity, hair loss, abnormal blood clotting, Raynaud’s phenomenon, seizures, mouth and nose ulcers. ...
... butterfly shaped rash on cheek and nose, sun or light sensitivity, hair loss, abnormal blood clotting, Raynaud’s phenomenon, seizures, mouth and nose ulcers. ...
Systemic Lupus Erythematosus
... Cutaneous (skin) lupus primarily affects the skin but may involve the hair and mucous membranes also commonly called discoid lupus ...
... Cutaneous (skin) lupus primarily affects the skin but may involve the hair and mucous membranes also commonly called discoid lupus ...
1. dia
... AUTOIMMUNE DISEASES • Chronic inflammatory conditions • Repair mechanisms cannot compete with tissue destruction caused by the immune system • Variety of symptoms and of target tissues • Mechanisms of recognition and effector functions are the same as those acting against pathogens and environmenta ...
... AUTOIMMUNE DISEASES • Chronic inflammatory conditions • Repair mechanisms cannot compete with tissue destruction caused by the immune system • Variety of symptoms and of target tissues • Mechanisms of recognition and effector functions are the same as those acting against pathogens and environmenta ...
Immunologic Alterations - NURSING FDTC Batch Spring 2011
... Anti-malarial medications (useful for rash and arthritis) ...
... Anti-malarial medications (useful for rash and arthritis) ...
SLE (systemic lupus erythematosus)
... nucleosome carries many separate epitopes, each of which can stimulate antibody production by a B cell specifc for that epitope. Any of these antibodies can bind thenucleosome particle to form an immune complex. Such potentially autoreactive B cells probably exist normally in the circulation but, pr ...
... nucleosome carries many separate epitopes, each of which can stimulate antibody production by a B cell specifc for that epitope. Any of these antibodies can bind thenucleosome particle to form an immune complex. Such potentially autoreactive B cells probably exist normally in the circulation but, pr ...
Types II and III: Antibody-Mediated and Antigen
... Goodpasture syndrome is an autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Persons with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomureli ...
... Goodpasture syndrome is an autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Persons with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomureli ...
Nursing Care of the Adult with Rheumatic Disorders
... African American women have a 3 times higher incidence and mortality A.A. tend to develop disease at a younger age and to develop increased severity of complications Also more common in women of Hispanic, Asian and Native American decent ...
... African American women have a 3 times higher incidence and mortality A.A. tend to develop disease at a younger age and to develop increased severity of complications Also more common in women of Hispanic, Asian and Native American decent ...
Types II and III: Antibody-Mediated and Antigen
... Goodpasture syndrome is an autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Persons with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomureli ...
... Goodpasture syndrome is an autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Persons with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomureli ...
SLE and Cardiovascular Disease
... Lupus and the Heart • SLE is a chronic, inflammatory disease with circulating Autoantibodies (“anti-self”); activated T cells (tissue autoimmunity); immune complexes (AntigenAntibody) and inflammatory Cytokines (cell messenger proteins) • Lupus Therapy over the last 4 decades has converted a rapidl ...
... Lupus and the Heart • SLE is a chronic, inflammatory disease with circulating Autoantibodies (“anti-self”); activated T cells (tissue autoimmunity); immune complexes (AntigenAntibody) and inflammatory Cytokines (cell messenger proteins) • Lupus Therapy over the last 4 decades has converted a rapidl ...
1. Malar rash
... 3- nonspecific activation of T or B cells. 4- Autoantibodies to DNA, RNA:Circulating immune complexes (Ag &Ab complexes are frequently observed and these may deposit in the kidney, skin, brain, lung, and other tissues. It causes inflammation and tissue damage by a number of mechanisms, notably fixat ...
... 3- nonspecific activation of T or B cells. 4- Autoantibodies to DNA, RNA:Circulating immune complexes (Ag &Ab complexes are frequently observed and these may deposit in the kidney, skin, brain, lung, and other tissues. It causes inflammation and tissue damage by a number of mechanisms, notably fixat ...
MAGNETIC RESONANCE IMAGING IN YOUNG PATIENTS WITH
... Discussion • Incidence : 14% to 75 % • Manifestations can range from mild to severe ...
... Discussion • Incidence : 14% to 75 % • Manifestations can range from mild to severe ...
C-43_Webb - Advocate Health Care
... occasionally initial presentation is as straightforward as lupus nephritis, often it is a complex picture involving multiple vague symptoms ranging from arthritis to psychosis. A clinician must have a high index of suspicion for diagnosis, versed on the symptoms, criteria for diagnosis and clinical ...
... occasionally initial presentation is as straightforward as lupus nephritis, often it is a complex picture involving multiple vague symptoms ranging from arthritis to psychosis. A clinician must have a high index of suspicion for diagnosis, versed on the symptoms, criteria for diagnosis and clinical ...
1. dia
... AUTOIMMUNE DISEASES • Chronic inflammatory conditions • Repair mechanisms cannot compete with tissue destruction caused by the immune system • Variety of symptoms and of target tissues • Mechanisms of recognition and effector functions are the same as those acting against pathogens and environmenta ...
... AUTOIMMUNE DISEASES • Chronic inflammatory conditions • Repair mechanisms cannot compete with tissue destruction caused by the immune system • Variety of symptoms and of target tissues • Mechanisms of recognition and effector functions are the same as those acting against pathogens and environmenta ...
Slide 1
... Erythematosus at Dr. Soetomo General Hospital Surabaya Background : Systemic Lupus Erythematosus (SLE) is an inflammatory multisystem disease of unknown etiology with diverse clinical and laboratory manifestations and variable course and prognosis. Organ damage may be involved singly or in any combi ...
... Erythematosus at Dr. Soetomo General Hospital Surabaya Background : Systemic Lupus Erythematosus (SLE) is an inflammatory multisystem disease of unknown etiology with diverse clinical and laboratory manifestations and variable course and prognosis. Organ damage may be involved singly or in any combi ...
outline24077 - American Academy of Optometry
... 6. Five-year survival rate of patients has increased from 50% in the 1950s to between 91% to 97% today 7. Mortalitiy rates are higher among SLE patients who develop infectious complications, seizures, lupus nephritis and renal failure. C. Etiology 1. Complex disease with an unknown etiology a combi ...
... 6. Five-year survival rate of patients has increased from 50% in the 1950s to between 91% to 97% today 7. Mortalitiy rates are higher among SLE patients who develop infectious complications, seizures, lupus nephritis and renal failure. C. Etiology 1. Complex disease with an unknown etiology a combi ...
Systemic lupus erythematosus
Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions.The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation.There is no cure for SLE. It is mainly treated with immunosuppressants such as cyclophosphamide and corticosteroids, the goal of which is to keep symptoms under control. SLE can be fatal. The leading cause of death is from cardiovascular disease due to accelerated atherosclerosis. Life expectancy has improved over the decades. The 10-year survival rate is 92–95% and is close to that of people without lupus. This is due in part to better treatments, but also to identification of milder cases.Global prevalence varies from 20 to 70 per 100,000. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of African-American or Caribbean descent. Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity. Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by a wolf's bite. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)