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ABSTRACT Drug Utilization Study in Hospitalized Patient with Systemic Lupus Erythematosus at Dr. Soetomo General Hospital Surabaya Background : Systemic Lupus Erythematosus (SLE) is an inflammatory multisystem disease of unknown etiology with diverse clinical and laboratory manifestations and variable course and prognosis. Organ damage may be involved singly or in any combination. Morbidity and mortality result from tissue damage due to the disease process or its therapy. Objectives : The purpose of this study was to analyze the drug utilization profile in related to clinical and laboratory data; and to identify the Drug Related Problem (DRP) that probably occurred. Methods : The study was using retrospective and prospective data by descriptive analysis at Dr. Soetomo General Hospital Surabaya during January 1st, 2006 to December 31st, 2007 and June 1st, 2007 to July 31st, 2007. Results : A total sample in this study were 53 patients that fulfilled inclusion criteria. SLE is more prevalent in women (96,2%) in their reproductive years 12 65 years (92,4%). Drug used were (1) Immunosuppresant agents frequently used (46,4%); chloroquine (23,2%); azathioprine (15,2%); cyclophosphamide (10,4%); IVIG (3,2%); mycophenolate mofetil (0,8%); and methotrexate (0,8%), (2) Antibiotics given to the patients were penicillins (4,2%); second generation of cephalosporine (1,4%); third generation of cephalosporine (52,6%); fourth generation of cephalosporine (1,4%); quinolones (13,8%); (2,8%); clindamycin (1,4%); fosfomycin (1,4%); metronidazole (1,4%); cloxacillin (1,4%), combination sefoperazon and sulbaktam (1,4%), (3) Analgesics class were paracetamol (53,5%); methampyrone (2,3%); tramadol (11,6%); mefenamic acid (14,6%); diclofenac sodium (7,0%); Salicylate (2,3%); ibuprofen (2,3%). The effectiveness therapy of in SLE patients could not be showed by using clinical and laboratory data becuase it were influenced by many factors such as infection, comorbid, etc. Clinical and laboratory data that used to know the effectiveness therapy of antibiotics were WBC, LED, temperature, the culture of microorganism and urinalysis. Therapy