Sub acute Bacterial Endocarditis Endocarditis
... dexamethasone. Biologic Therapy: Rituximab is a biologic protein chimeric monoclonal antibody drug that attacks the B- cells, which are the precursors to cells that make antibodies. This type of treatment is considered a form of passive immunotherapy. Responses to ritxumab reported in patients with ...
... dexamethasone. Biologic Therapy: Rituximab is a biologic protein chimeric monoclonal antibody drug that attacks the B- cells, which are the precursors to cells that make antibodies. This type of treatment is considered a form of passive immunotherapy. Responses to ritxumab reported in patients with ...
matosus in Nairobi, Kenya - university of nairobi staff profiles
... Data from United Kingdom show that the definitive feature in 85% of patients was musculoskeletal and/ or cutaneous6. A study by Cooper et al7 analysed racial differences in the South-eastern USA and found more discoid lupus, more nephritis and a higher prevalence of anti-Sm and anti-RNP antibodies i ...
... Data from United Kingdom show that the definitive feature in 85% of patients was musculoskeletal and/ or cutaneous6. A study by Cooper et al7 analysed racial differences in the South-eastern USA and found more discoid lupus, more nephritis and a higher prevalence of anti-Sm and anti-RNP antibodies i ...
Autoimmune Diseases
... • Autoimmune diseases are the result of damage to the body by the presence of autoantibodies or autoreactive cells • About 2% of the population are affected by such diseases • There is a breakdown of self tolerance in these individuals • Self tolerance is brought about by such mechanisms as clonal d ...
... • Autoimmune diseases are the result of damage to the body by the presence of autoantibodies or autoreactive cells • About 2% of the population are affected by such diseases • There is a breakdown of self tolerance in these individuals • Self tolerance is brought about by such mechanisms as clonal d ...
Malaria in Pregnancy & Anaemia in Pregnancy
... Physicians and scientists have identified more than 80 different autoimmune diseases. Some are well known, rheumatoid arthritis, multiple sclerosis, type 1 diabetes systemic lupus; ...
... Physicians and scientists have identified more than 80 different autoimmune diseases. Some are well known, rheumatoid arthritis, multiple sclerosis, type 1 diabetes systemic lupus; ...
Basil Fathalla presentation
... F. Minoia, S. Davi, A. Horne, et al.: Clinical features, treatment and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis A multinational, multicenter study of 362 patients. Arthritis ...
... F. Minoia, S. Davi, A. Horne, et al.: Clinical features, treatment and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis A multinational, multicenter study of 362 patients. Arthritis ...
(SLE).
... • The arthritis of lupus is usually found on both sides of the body and does not cause deformity of the joints. Swelling and tenderness must be present. • The most frequently involved joints are those of the hand, knees, and wrists. • People with lupus can suffer from a certain type of low blood flo ...
... • The arthritis of lupus is usually found on both sides of the body and does not cause deformity of the joints. Swelling and tenderness must be present. • The most frequently involved joints are those of the hand, knees, and wrists. • People with lupus can suffer from a certain type of low blood flo ...
Treatment name Type Focus of Studies Company or Organization
... Since 1999, the Alliance for Lupus Research (ALR) has given more money to lupus research than any non-governmental agency in the world, and is committed to identifying new and improved treatments for the disease. The ALR is proud to be a catalyst for increased attention to lupus research and will co ...
... Since 1999, the Alliance for Lupus Research (ALR) has given more money to lupus research than any non-governmental agency in the world, and is committed to identifying new and improved treatments for the disease. The ALR is proud to be a catalyst for increased attention to lupus research and will co ...
- Dr. Robert Fox
... Genome-Wide Association Parallels-our studies on cytokine profiles • Strongest is HLA-DR and acquired immune system leading to T-cell/B-cell production of autoantibody. • Next strongest are Innate Immune markers associated with Type 1 IFN production. • As noted above, also find a homing receptor (CX ...
... Genome-Wide Association Parallels-our studies on cytokine profiles • Strongest is HLA-DR and acquired immune system leading to T-cell/B-cell production of autoantibody. • Next strongest are Innate Immune markers associated with Type 1 IFN production. • As noted above, also find a homing receptor (CX ...
Systemic lupus erythematosus and myasthenia gravis
... immune disease with no predilection to involve specific organs, and is characterized by the pres ence of anti‑native DNA and anti‑SM antibodies, which may contribute to the occurrence of sus tained proinflammatory state in the body.1,2 Im mune disorders associated with polyclonal activa tion of ...
... immune disease with no predilection to involve specific organs, and is characterized by the pres ence of anti‑native DNA and anti‑SM antibodies, which may contribute to the occurrence of sus tained proinflammatory state in the body.1,2 Im mune disorders associated with polyclonal activa tion of ...
Rheumatoid Arthritis
... • Have to ensure that condition is not secondary to a drug response (several drugs produce lupus-like syndrome) – Agents strongly associated include: • Procainamide (cardiac arrhythmias), hydralazine (high blood pressure) and isoniazid (anti-tuberculosis) • Others include: phenytoin, quinidine, tetr ...
... • Have to ensure that condition is not secondary to a drug response (several drugs produce lupus-like syndrome) – Agents strongly associated include: • Procainamide (cardiac arrhythmias), hydralazine (high blood pressure) and isoniazid (anti-tuberculosis) • Others include: phenytoin, quinidine, tetr ...
Osteoarthritis (OA), Rheumatoid Arthritis (RA) and Systemic Lupus
... b. Impaired physical mobility related to weakness, stiffness, or pain on ambulation 1) Goal – maintain or improve joint function through a balance of rest and activity 2) Interventions:(p.1701) c. Self-care deficits related to joint deformity and pain with activity 1) Goal - achieve independence in ...
... b. Impaired physical mobility related to weakness, stiffness, or pain on ambulation 1) Goal – maintain or improve joint function through a balance of rest and activity 2) Interventions:(p.1701) c. Self-care deficits related to joint deformity and pain with activity 1) Goal - achieve independence in ...
Externconference03-05
... Active hair loss for 4 months Abnormal skin manifestation on scalp, ...
... Active hair loss for 4 months Abnormal skin manifestation on scalp, ...
innate adaptive - El Corte Inglés
... SLE is complex • SLE is a multigenic disease that involves loss of tolerance involving both innate and adaptive immune pathways. • Multiple triggers are likely to be involved in disease initiation and perpetuation. • Continuous exposure to excess nucleic acid containing material amplifies the diseas ...
... SLE is complex • SLE is a multigenic disease that involves loss of tolerance involving both innate and adaptive immune pathways. • Multiple triggers are likely to be involved in disease initiation and perpetuation. • Continuous exposure to excess nucleic acid containing material amplifies the diseas ...
Medical-Surgical Nursing: An Integrated Approach, 2E Chapter 22
... Since 1987, when universal precautions (now called Standard Precautions) were mandated, exposure to latex by health care workers has dramatically increased. By June, 1996, 28 latex-related deaths had been reported to the FDA. ...
... Since 1987, when universal precautions (now called Standard Precautions) were mandated, exposure to latex by health care workers has dramatically increased. By June, 1996, 28 latex-related deaths had been reported to the FDA. ...
Activated B Cell
... The role of FcR- immune complex interactions in mediating inflammation and immune injury in SLE • Immune complexes interact with Fc receptors to initiate a receptor mediated proinflammatory program • Polymorphism of FcRIIa and FcRIII in humans affect affinity of these FcR for IgG and influence the ...
... The role of FcR- immune complex interactions in mediating inflammation and immune injury in SLE • Immune complexes interact with Fc receptors to initiate a receptor mediated proinflammatory program • Polymorphism of FcRIIa and FcRIII in humans affect affinity of these FcR for IgG and influence the ...
Self tolerance
... components may induce thrombocytopenia, leukopenia, anemia. -neurologic abnormalities with focal neurologic deficits and/or neuropsychiatric symptoms ...
... components may induce thrombocytopenia, leukopenia, anemia. -neurologic abnormalities with focal neurologic deficits and/or neuropsychiatric symptoms ...
Understanding Lupus
... Autopsy data shows CAD in 40% of SLE patients as opposed to only 2% of age matched controls. Atherosclerotic plaque burden (via carotid intima media thickness measurements and by coronary calcium scores) is higher in patients with SLE than in controls “Lupus dyslipoproteinemia” is low HDL, hig ...
... Autopsy data shows CAD in 40% of SLE patients as opposed to only 2% of age matched controls. Atherosclerotic plaque burden (via carotid intima media thickness measurements and by coronary calcium scores) is higher in patients with SLE than in controls “Lupus dyslipoproteinemia” is low HDL, hig ...
Questions
... individuals share a gene variation for a given complement component. This is suggestive of an underlying genetic cause or influence. If the function of the gene product is compromised in these individuals, a correlation between the gene and disease expression is supported. Indeed, it was found that ...
... individuals share a gene variation for a given complement component. This is suggestive of an underlying genetic cause or influence. If the function of the gene product is compromised in these individuals, a correlation between the gene and disease expression is supported. Indeed, it was found that ...
laboratory tests in rheumatology
... Each rheumatic disease has a set of criteria used to make the diagnosis of that particular disease process. A lab test is just a small portion of that. Normal individuals may have positive autoantibody tests without any disease process. None of these tests is perfect. ...
... Each rheumatic disease has a set of criteria used to make the diagnosis of that particular disease process. A lab test is just a small portion of that. Normal individuals may have positive autoantibody tests without any disease process. None of these tests is perfect. ...
Autoimmune Diseases
... UVB=> flares of both cutaneous and internal organ lupus (some antigens, like Ro, La, RNP, but not chromatin antigens and other nuclear components are translocated to keratinocyte cell surface, favorising the immune response); decrease DNA methylation and induces gene expression; increase expression ...
... UVB=> flares of both cutaneous and internal organ lupus (some antigens, like Ro, La, RNP, but not chromatin antigens and other nuclear components are translocated to keratinocyte cell surface, favorising the immune response); decrease DNA methylation and induces gene expression; increase expression ...
Rheumatology_Laboratory_Talk
... titer doesn’t correlate with disease activity a negative ANA “rules out” SLE most of the ...
... titer doesn’t correlate with disease activity a negative ANA “rules out” SLE most of the ...
Document
... Coronary Heart Disease in Lupus The prevalence ranges from 6 to 15% The incidence of myocardial infarction is five times higher in lupus ...
... Coronary Heart Disease in Lupus The prevalence ranges from 6 to 15% The incidence of myocardial infarction is five times higher in lupus ...
Maladies auto-immunes
... • Fluorescent ANA: The fluorescent test for ANA is the best screen for SLE; positive ANA tests (usually in high titer: > 1:80) occur in > 98%. However, positive ANA tests can also occur in RA, other connective tissue diseases, cancers, and even in the general population. The false‐positive rate ...
... • Fluorescent ANA: The fluorescent test for ANA is the best screen for SLE; positive ANA tests (usually in high titer: > 1:80) occur in > 98%. However, positive ANA tests can also occur in RA, other connective tissue diseases, cancers, and even in the general population. The false‐positive rate ...
Systemic lupus erythematosus
Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions.The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation.There is no cure for SLE. It is mainly treated with immunosuppressants such as cyclophosphamide and corticosteroids, the goal of which is to keep symptoms under control. SLE can be fatal. The leading cause of death is from cardiovascular disease due to accelerated atherosclerosis. Life expectancy has improved over the decades. The 10-year survival rate is 92–95% and is close to that of people without lupus. This is due in part to better treatments, but also to identification of milder cases.Global prevalence varies from 20 to 70 per 100,000. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of African-American or Caribbean descent. Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity. Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by a wolf's bite. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)