The danger model in deciphering autoimmunity
... and preventing its binding on the surface blocks this effect altogether [25]. Subsequent release of potential danger signals including heat-shock proteins and HMGB1, such as by secondary necrotic transformation, may further influence the APC response and mode of antigen display. In these ways, facto ...
... and preventing its binding on the surface blocks this effect altogether [25]. Subsequent release of potential danger signals including heat-shock proteins and HMGB1, such as by secondary necrotic transformation, may further influence the APC response and mode of antigen display. In these ways, facto ...
... Expectations from the community to become better people will motivate patient to meet these expectations and challenge them to become what they want, such as recovering from the pain or achieve its goals. Opportunity to do fun activities, participate in counseling and training about Lupus (opportun ...
The Efficacy of Traditional Chinese Medicine on
... Erythematous (SLE), Epstein Barr Virus (HSV-4) with small intestine permeation and the effectiveness of TCM in reducing the secondary symptoms of SLE. This will include symptoms of inflammation, digestive disorders, chronic pain, cardiac dysfunction, renal dysfunction and epithelial dysfunction. Som ...
... Erythematous (SLE), Epstein Barr Virus (HSV-4) with small intestine permeation and the effectiveness of TCM in reducing the secondary symptoms of SLE. This will include symptoms of inflammation, digestive disorders, chronic pain, cardiac dysfunction, renal dysfunction and epithelial dysfunction. Som ...
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
... Hypovitamin D may be the cause of SLE, as supported by evidence that vitamin D has a role in the regulation of the immune system that can prevent autoimmunity [15], thus low levels of vitamin D may disrupt the regulation of the immune system. The involvement of vitamin D in the immune response demon ...
... Hypovitamin D may be the cause of SLE, as supported by evidence that vitamin D has a role in the regulation of the immune system that can prevent autoimmunity [15], thus low levels of vitamin D may disrupt the regulation of the immune system. The involvement of vitamin D in the immune response demon ...
Identification of the yaa lupus as a IIr
... antigens [9]. Thus, it appears that the Yaa locus bears gene(s) that influence antigenicity of RNA-containing antigens. Since Yaa was known to be associated with a marginal zone defect and generalized B-cell hyper-reactivity [10], Pisitkun and colleagues reasoned that, by deleting Bruton’s tyrosine ...
... antigens [9]. Thus, it appears that the Yaa locus bears gene(s) that influence antigenicity of RNA-containing antigens. Since Yaa was known to be associated with a marginal zone defect and generalized B-cell hyper-reactivity [10], Pisitkun and colleagues reasoned that, by deleting Bruton’s tyrosine ...
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES
... involved in the pathogenesis of lupus nephritis, resulting in a wide spectrum of renal lesions. DNA and anti-DNA antibodies are known to be concentrated in glomerular deposits in the subendothelial location and are likely to play a central role in the pathogenesis of proliferative lupus nephritis. D ...
... involved in the pathogenesis of lupus nephritis, resulting in a wide spectrum of renal lesions. DNA and anti-DNA antibodies are known to be concentrated in glomerular deposits in the subendothelial location and are likely to play a central role in the pathogenesis of proliferative lupus nephritis. D ...
Review Cytomegalovirus infection in patients with systemic lupus
... (32). Furthermore, epitopes of La (SSB) antigens in humans with autoimmune disease show sequence similarities to proteins from the herpes group of viruses, including CMV (33). Also, the expression of La antigens together with human leukocyte antigen (HLA) class II molecules is induced on the surface ...
... (32). Furthermore, epitopes of La (SSB) antigens in humans with autoimmune disease show sequence similarities to proteins from the herpes group of viruses, including CMV (33). Also, the expression of La antigens together with human leukocyte antigen (HLA) class II molecules is induced on the surface ...
Understanding Lupus and Auto-Immune Diseases
... a. combination of hereditary, environmental, and possible hormonal factors contributes to lupus 5. What part of the body does Discoid Lupus usually affect? a. the skin 6. Name 2 symptoms of the disease: a. extreme fatigue b. painful or swollen joints c. inexplicable fever d. skin rashes e. kidney pr ...
... a. combination of hereditary, environmental, and possible hormonal factors contributes to lupus 5. What part of the body does Discoid Lupus usually affect? a. the skin 6. Name 2 symptoms of the disease: a. extreme fatigue b. painful or swollen joints c. inexplicable fever d. skin rashes e. kidney pr ...
Cutaneous And Urticarial Vasculitis
... cutaneous vasculitis may overlap with urticaria Systemic diseases with cutaneous vasculitis constitute the majority of cases, but there are cases of cutaneous vasculitis without a systemic disorder Constitutional symptoms often accompany the rash when associated with a systemic disorder Laboratory t ...
... cutaneous vasculitis may overlap with urticaria Systemic diseases with cutaneous vasculitis constitute the majority of cases, but there are cases of cutaneous vasculitis without a systemic disorder Constitutional symptoms often accompany the rash when associated with a systemic disorder Laboratory t ...
Autoimmune Disorders in Pregnancy
... • Data limited since Systemic Sclerosis usually develops after childbearing years • Course depends on disease present prior to pregnancy • Based on amount of small-vessel disease present ...
... • Data limited since Systemic Sclerosis usually develops after childbearing years • Course depends on disease present prior to pregnancy • Based on amount of small-vessel disease present ...
Natural killer cell activity in Sjogren`s syndrome and systemic lupus
... affinity IL-2 receptors,34 an abnormality in postreceptor signalling,35 or the presence of antibodies to lymphocytes.' 36 Other inhibitory factors of NK cell activity might be circulating immune complexes,4 which are indeed often found in the serum of patients with Sjogren's syndrome or SLE. In our ...
... affinity IL-2 receptors,34 an abnormality in postreceptor signalling,35 or the presence of antibodies to lymphocytes.' 36 Other inhibitory factors of NK cell activity might be circulating immune complexes,4 which are indeed often found in the serum of patients with Sjogren's syndrome or SLE. In our ...
Cytoplasmic Hep-2 patterns
... antigen specificity needs to be revealed by techniques other than IIF (ELISA, bead assays, chip assays, immunodiffusion etc). – Some ANA have less clear-cut clinical utility, mainly because only modest efforts have been spent to harmonize their recognition by IIF and study their antigen specificity ...
... antigen specificity needs to be revealed by techniques other than IIF (ELISA, bead assays, chip assays, immunodiffusion etc). – Some ANA have less clear-cut clinical utility, mainly because only modest efforts have been spent to harmonize their recognition by IIF and study their antigen specificity ...
lupus nephritis - Nephro
... • The incidence and prevalence of lupus and LN are influenced by age,gender, ethnicity, geographic region, but across populations, clinically important kidney disease will occur in 40% of patients. • The peak incidence of lupus is age 15 to 45 years, with women to men by 10 : 1. • Among lupus patien ...
... • The incidence and prevalence of lupus and LN are influenced by age,gender, ethnicity, geographic region, but across populations, clinically important kidney disease will occur in 40% of patients. • The peak incidence of lupus is age 15 to 45 years, with women to men by 10 : 1. • Among lupus patien ...
Belimumab (Benlysta®)
... Systemic lupus erythematosus (SLE) is the most common type of lupus which can lead to symptoms of fever, swollen joints, anemia, and kidney failure. Symptoms of lupus vary widely depending on the individual case and the form of lupus present. There are generally four recognized forms or types of lup ...
... Systemic lupus erythematosus (SLE) is the most common type of lupus which can lead to symptoms of fever, swollen joints, anemia, and kidney failure. Symptoms of lupus vary widely depending on the individual case and the form of lupus present. There are generally four recognized forms or types of lup ...
B cell targeted therapy in autoimmunity
... Autoimmunity results from a break in self-tolerance involving humoral and/or cell-mediated immune mechanisms. Part of the pathological consequence of a failure in central and/or peripheral tolerance, results from survival and activation of self-reactive B cells. Such B cells produce tissue-damaging ...
... Autoimmunity results from a break in self-tolerance involving humoral and/or cell-mediated immune mechanisms. Part of the pathological consequence of a failure in central and/or peripheral tolerance, results from survival and activation of self-reactive B cells. Such B cells produce tissue-damaging ...
Current and novel therapeutics in the treatment of systemic lupus erythematosus
... inflammatory responses through cytokine secretion and regulation of other immune cells. Ideally, B cell–targeted therapies would eliminate pathogenic B cells, promote the expansion and function of protective B cells, or both. Current therapies that target the B-cell compartment include antibodies to ...
... inflammatory responses through cytokine secretion and regulation of other immune cells. Ideally, B cell–targeted therapies would eliminate pathogenic B cells, promote the expansion and function of protective B cells, or both. Current therapies that target the B-cell compartment include antibodies to ...
AJS_Paper3_Autoimmunity
... in the joints, most commonly the wrists and hands. As with many other autoimmune diseases, the cause is unknown but is expected to have both genetic and environmental components. The physical mechanism of the disorder involves intense inflammation of the synovium6 caused by excessive release of infl ...
... in the joints, most commonly the wrists and hands. As with many other autoimmune diseases, the cause is unknown but is expected to have both genetic and environmental components. The physical mechanism of the disorder involves intense inflammation of the synovium6 caused by excessive release of infl ...
Cutaneous Lupus Erythematosus
... which are directly pathogenic, including dsDNA, and Ro/SSA antibodies. Lupus patients have reduced clearance of immune complexes by the reticuloendothelial system Most of the tissue injury is due to B-cells due to immune complex and complement mediated damage through 1. Direct cell death 2. ...
... which are directly pathogenic, including dsDNA, and Ro/SSA antibodies. Lupus patients have reduced clearance of immune complexes by the reticuloendothelial system Most of the tissue injury is due to B-cells due to immune complex and complement mediated damage through 1. Direct cell death 2. ...
IMMUNOLOGIC DEFICIENCY SYNDROMES
... Visceral lesions are caused by DNA-anti-DNA complex deposits. High titer anti-dsDNA = nephritis (titers used to monitor therapy & disease progression) Anti-SS-A (Ro)/B (La): Maternal - fetal transfer = present in 90% of mothers with neonatal lupus (heart block) Anti-SS-A/B and neonatal lupus also se ...
... Visceral lesions are caused by DNA-anti-DNA complex deposits. High titer anti-dsDNA = nephritis (titers used to monitor therapy & disease progression) Anti-SS-A (Ro)/B (La): Maternal - fetal transfer = present in 90% of mothers with neonatal lupus (heart block) Anti-SS-A/B and neonatal lupus also se ...
Discoid lupus erythematosus - British Association of Dermatologists
... Discoid lupus erythematosus is an uncommon skin rash, usually made worse by exposure to sunlight. The term ‘lupus erythematosus’ is applied to a range of related disorders. At one end of the range is systemic lupus erythematosus, which can damage internal organs, whilst right at the other end of the ...
... Discoid lupus erythematosus is an uncommon skin rash, usually made worse by exposure to sunlight. The term ‘lupus erythematosus’ is applied to a range of related disorders. At one end of the range is systemic lupus erythematosus, which can damage internal organs, whilst right at the other end of the ...
Hypersensitivity
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmers lung’ and ‘piegeon-breeder’s lung’ ...
... • Local vasculitis develops as a result of immune complex deposition • Inhaled antigens (fungi, animal feces) may induce similar reaction in the lung • IgG type antibody • ‘Farmers lung’ and ‘piegeon-breeder’s lung’ ...
Effect of eliminating intermittent white blood cells
... of B cell and a member of the CR2 complex. It can regulate the activation and proliferation of B cell, and participate in the signal transmission of B cell. The abnormality of T cell subgroup may play an important role in inducing the disease.[5,6] The decreased number and dysfunction of T supply ce ...
... of B cell and a member of the CR2 complex. It can regulate the activation and proliferation of B cell, and participate in the signal transmission of B cell. The abnormality of T cell subgroup may play an important role in inducing the disease.[5,6] The decreased number and dysfunction of T supply ce ...
140
... presentation of viral peptides by MHC class I and II; these may persist and remain hidden from the immune system [12]. These viral peptides and/or tissue antigens altered by the virus may induce an atypical immune response. The concept of epitope spreading, whereby the tissue damage from a primary i ...
... presentation of viral peptides by MHC class I and II; these may persist and remain hidden from the immune system [12]. These viral peptides and/or tissue antigens altered by the virus may induce an atypical immune response. The concept of epitope spreading, whereby the tissue damage from a primary i ...
- Robert Fox, MD, Ph.D.
... treatment of dry eyes/dry mouth to our patients in the limited time allowed in a patient revisit? This is a practical limitation that is very important aspect of patient care. ...
... treatment of dry eyes/dry mouth to our patients in the limited time allowed in a patient revisit? This is a practical limitation that is very important aspect of patient care. ...
Lupus and the Lung
... commonly mild or absent. A more severe effect of lupus on the lung is called acute lupus pneumonitis. Individuals experience the sudden development of cough, shortness of breath, chest pain, and fever. Its symptoms are very similar to the pneumonia caused by an infection. Though this is a rare manif ...
... commonly mild or absent. A more severe effect of lupus on the lung is called acute lupus pneumonitis. Individuals experience the sudden development of cough, shortness of breath, chest pain, and fever. Its symptoms are very similar to the pneumonia caused by an infection. Though this is a rare manif ...
Systemic lupus erythematosus
Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions.The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation.There is no cure for SLE. It is mainly treated with immunosuppressants such as cyclophosphamide and corticosteroids, the goal of which is to keep symptoms under control. SLE can be fatal. The leading cause of death is from cardiovascular disease due to accelerated atherosclerosis. Life expectancy has improved over the decades. The 10-year survival rate is 92–95% and is close to that of people without lupus. This is due in part to better treatments, but also to identification of milder cases.Global prevalence varies from 20 to 70 per 100,000. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of African-American or Caribbean descent. Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity. Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by a wolf's bite. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)