خود ایمنی
... A) The patient has an acquired immunodeficiency syndrome. B) Immune complex formation and complement are the main contributors to insulitis. C) In the islets of the pancreas, b cells have upregulated MHC class II and Fas molecules, making them susceptible to cell death by immune cells. D) There is a ...
... A) The patient has an acquired immunodeficiency syndrome. B) Immune complex formation and complement are the main contributors to insulitis. C) In the islets of the pancreas, b cells have upregulated MHC class II and Fas molecules, making them susceptible to cell death by immune cells. D) There is a ...
Greg Black and Julie Tyler
... 5. Five-year survival rate of patients has increased from 50% in the 1950s to between 91% to 97% today 6. Mortalitiy rates are higher among SLE patients who develop infectious complications, seizures, lupus nephritis and renal failure. ...
... 5. Five-year survival rate of patients has increased from 50% in the 1950s to between 91% to 97% today 6. Mortalitiy rates are higher among SLE patients who develop infectious complications, seizures, lupus nephritis and renal failure. ...
Lupus Erythematosis - University of California, Irvine
... Autoimmune disease › “The great imitator” › Inflammation › Episodic flares ...
... Autoimmune disease › “The great imitator” › Inflammation › Episodic flares ...
Systemic Lupus Erythematosus
... There is no single definitive test for SLE. Diagnosis depends upon the presence of several of the symptoms listed above plus a series of suggestive findings on laboratory tests. Routine blood tests may reveal anemia and changes in the white blood cell count. Kidney problems are often present as part ...
... There is no single definitive test for SLE. Diagnosis depends upon the presence of several of the symptoms listed above plus a series of suggestive findings on laboratory tests. Routine blood tests may reveal anemia and changes in the white blood cell count. Kidney problems are often present as part ...
A beginners guide to SLE
... antibodies to cellular components of the nucleus, cytoplasm and cell membrane has led to the concept that lupus is an auto-immune disease. The major immune response appears to be directed against nuclear antigens. These anti-nuclear antibodies are responsible for the LE cells and immuno-fluorescence ...
... antibodies to cellular components of the nucleus, cytoplasm and cell membrane has led to the concept that lupus is an auto-immune disease. The major immune response appears to be directed against nuclear antigens. These anti-nuclear antibodies are responsible for the LE cells and immuno-fluorescence ...
Case Study #87: Systemic Lupus Erythematosus
... (Cytoxan) 100mg/m2/day orally in two divided doses. D.W. Weighs 140 lbs and is 5ft, 4in tall. How much will she receive with each dose? ...
... (Cytoxan) 100mg/m2/day orally in two divided doses. D.W. Weighs 140 lbs and is 5ft, 4in tall. How much will she receive with each dose? ...
Who Gets Lupus?
... Complement activation plays a critical role in the inflammatory process and tissue damage in SLE, but early complement deficiencies cause SLE. ...
... Complement activation plays a critical role in the inflammatory process and tissue damage in SLE, but early complement deficiencies cause SLE. ...
Systemic_Lupus_Erythematosus
... – 10-year survival rates ranging from 75-85% – > 90% of patients surviving more than 5 years • Early deaths: – Infection – Active disease – Thrombosis – Renal failure • Late complications: – Atherosclerosis – Osteoporosis – Avascular bone necrosis – Dementia ...
... – 10-year survival rates ranging from 75-85% – > 90% of patients surviving more than 5 years • Early deaths: – Infection – Active disease – Thrombosis – Renal failure • Late complications: – Atherosclerosis – Osteoporosis – Avascular bone necrosis – Dementia ...
Systemic lupus erythematosus
... juvenile population. It consists of 11 criteria (which include malar rash, oral or nasal ulceration, nephritis and a positive test for nuclear antibodies) of which four have to be met, simultaneously or periodically before a diagnosis can be fulfilled. A complex interplay between genetic and environ ...
... juvenile population. It consists of 11 criteria (which include malar rash, oral or nasal ulceration, nephritis and a positive test for nuclear antibodies) of which four have to be met, simultaneously or periodically before a diagnosis can be fulfilled. A complex interplay between genetic and environ ...
Systemic lupus erythematosus
Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body’s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions.The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation.There is no cure for SLE. It is mainly treated with immunosuppressants such as cyclophosphamide and corticosteroids, the goal of which is to keep symptoms under control. SLE can be fatal. The leading cause of death is from cardiovascular disease due to accelerated atherosclerosis. Life expectancy has improved over the decades. The 10-year survival rate is 92–95% and is close to that of people without lupus. This is due in part to better treatments, but also to identification of milder cases.Global prevalence varies from 20 to 70 per 100,000. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of African-American or Caribbean descent. Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity. Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by a wolf's bite. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)