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Transcript
BME 273
Senior Design Project
Group 25
Scientific Design
BioMEMs cell culture device
Cell Culture Design
Cross Section
Materials
Polydimethlysiloxane (PDMS)
Negative Resist (SU-8)
Silicon Wafers
MEMS laboratory
8 mm masks
Platinum (working electrodes)
Silver (reference Ag/AgCl electrodes)
Fabrication Steps
Lay down SU-8 on silicon wafer, expose using
mask, and develop lower region for cell insertion
and perfusion.
Cast PDMS replica of master
Lay down SU-8 on silicon wafer, expose using
mask, and develop upper region for pneumatic
control of cell insertion channels.
Cast PDMS replica of master and then lay over
top of lower region
Business Strategy
Developing a strategy to present
to venture capitalists
Components
Market & Demand Environment
Technological Environment
Competitive Environment
Economic & Policy Environment
Strategic Implications of Innovation Success
Factors
Technology Intelligence (Contacts)
Product Development
Financing
Main Focus Points
Nano-scale
Simulate in vivo better than current
methods
Scale up the number of cell cultures per
experiment
Automated experiments
Cost efficiency
Portable experimentation?
Applications
Replace conventional cell culture
techniques


Scale up
Reduce number of lab technicians  cost
efficient
Drug development

Monitor cells before & after drug
Drug Companies
Pfizer
Johnson & Johnson
GlaxoSmithKline
Novartis
Merck
Eli Lilly
Abbott Laboratories
http://finance.yahoo.com
Project Schedule – Microsoft
Project
Project Schedule – Gant Chart
References
http://finance.yahoo.com
Fabrication of miniature Clark oxygen sensor integrated
with microstructure


Ching-Chou Wu, Tomoyuki Yasukawa, Hitoshi Shiku, Tomokazu
Matsue
http://www.bme.vanderbilt.edu/srdesign/2005/group25/272_sdart
icle.pdf
A BioMEMS Review: MEMS Technology for
Physiologically Integrated Devices


AMY C. RICHARDS GRAYSON, REBECCA S. SHAWGO,
AUDREY M. JOHNSON, NOLAN T. FLYNN, YAWEN LI,
MICHAEL J. CIMA, AND ROBERT LANGER
http://www.bme.vanderbilt.edu/srdesign/2005/group25/BioMEMS
_review.pdf