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Tissues and Organs Comprising the Immune Response System Where components of the immune response originate, differentiate, meet, interact, and function Folder Title: Tiss&Org(NoTP) Updated: November 15, 2016 Interactions that have to take place in the Immune Response: Slides 3 to 9 Marcophage and T-Cell Kissing APC and T-Cells Macrophage to T-Cell Interaction Helper T-cell B-Cell Interaction CD4 co-receptor B-Cell Activation See figure 2-7, Kuby, 4th Ed., p. 36 B-Cell: Small, Blast, and Plasma See Figure 2-7, Kuby 4th Ed. p. 36 Where do these cells originate? Primary Lymphoid Organs: Bone Marrow and Thymus Where do they go to interact with each other and with Targets? Secondary Lymphoid Organs Where do they carry out their functions? Related to Figure 2-13, Kuby, 4th Edition, p. 47 Primary and Secondary Lymphoid Animations Produced for Kuby Immunology (In Class Do animations from the Book CD) Chapter 2 Animation. Cells and Organs. Last Panel Shows Organs of Immune Response Please put away all notes and any devices except for your Turning Point NXT Transmitter. No papers or computers on your desk please. No communication between or among students. Rank 1 2 3 4 5 6 Responses 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% 1 2 3 4 5 6 0% Rank 1 2 3 4 5 6 Responses 100% 90% 80% 70% 60% Blue thing 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% 1 2 3 4 5 6 0% ? Rank 1 2 3 4 5 6 Responses 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% 4 5 6 0% Purple Thing 1 2 3 Primary Lymphoid Organ: The Thymus: Where Lymphocytes are Selected, Edited, and “Educated” Thymus Photo Thymus Cartoon Diagrammatic Cross Section of Thymus. Figure 2-14, Kuby, 4th Edition, p. 48 ThymusCross CD4 and CD8 in Thymus To Here: Tuesday November 12, 2015 Before Exam Secondary Lymphoid Organs: Where Cells and Targets Meet. Where Lymphocytes & Myelocytes Differentiate and Mature MALT and M-Cells See Figure 2-22, Kuby 4th Ed. p. 56 MALT and IgA See Figure 2-22 Kuby, 4th Ed. p. 56 Animations Produced for Kuby Immunology Chapter 11 Animation. Signal Transduction Signal, Receptors, and co-receptor Pairs Secrets of Signaling 1. How Do You Knock on a Door? Why that way? 2. Why can the police officer directing traffic blow his whistle only once and get a response? 3. Why does your computer say “Are You Sure You Want to Delete File XYZ?” 4. When the class was directed to do “Bunny Ears” behind the person next to them, only a few persons responded. Why was that? 5. A different set of persons responded when asked to raise their right hand. Why was that? 6. No one responded when the class was asked to stand up. Why? Secrets of Signaling (2) 7. Only the people in the front of the room responded when I invited the class to do what all classes would love to do to a pain-in-the neck Prof. Why was that? 8. I asked the class in plain English to raise both hands but no one complied. Why is that? What did that illustrate about properties of signaling. 9. Why does the T-Helper Cell physically attach itself to the macrophage? What is the advantage of that? 10. Why does the T-Cell use a co-receptor in addition to its T-Cell Receptor? 11. Why does a T-Cell look for a second signal (B7 to CD28) before the T-cell will act? Costimulatory signals: B7 – CD28 Costimulatory Signals: T-Cell to MPh Cancer Eluding Costimulatory Signal Cell Surface Markers Functional Surface Molecules that Allow Specific Cells to perform specific tasks. Become identifiers of Specific Cells Analogy of a Basketball Player Person 1: Person 2: Person 3: Person 4: Person 5: 5 ft 5”, 160 lbs bespectacled old geezer 5 ft 11”, 280 lbs, 22-year old guy, all muscle 5 ft 5”, 135 lbs, 20-year-old woman 7 ft 1” , 200 lbs, 22 year-old guy 5 ft 8”, 150 lbs, 22 year-old guy Which Person: A. Is a varsity basketball player? B. Plays on the women’s field-hockey team? C. Is a boring old professor? D. Is a varsity football player for SU? E. Is a men’s cross-country runner? 1C; 2D; 3B; 4A; 5E CD’s on B, T, and NK Cells Surface Determinants on B-Cells: Immunoglobulins B7 Surface Determinants on T-Lymphocytes: Note: CD4 TH CD8 TC CD28 and CD3 Both. NK Determinants: CD56 CD16 CD8 CD Markers in Leukemia Diagnosis Staging Prognosis Treatment (“ALL” = Acute Lymphocytic Leukemia) T-Cell ALL Markers Kuby, 5th Edition p. 157 Pre-B-Cell ALL Markers (“ALL” = Acute Lymphocytic Leukemia) Kuby, 5th Edition p. 157 (“CLL” = Chronic Lymphocytic Leukemia) B-Cell CLL Markers Kuby, 5th Edition p. 157 Leukocyte Recirculation How Do Circulating Hematopoietic Cells “Know” Where They Are? How Do they Stick? How Do they Move? See Animation on CD Chapter 13 Leucocytes Primary Lymphoid Organs Lymphocyte Recirculation Secondary Lymphoid Organs Leucocytes in Capillaries Cartoon Leucocytes in Capillaries Photo Extravasation (Getting out of the Blood Stream) of Naïve T-Cell into Lymph Node CAM = Cell Adhesion Molecule Adhesion: Leucocytes to Endothelium Cell Surface Receptors and Signals in Leucocyte Extravasation (Non-inflamed Endothelium) CAM = Cell Adhesion Molecules Membrane of Circulating Leucocytes “CHO” = carbohydrates Lectins = carbohydrate binding proteins Endothelial Cells Lining Capillaries CAMinCap Adhesion in Capilaries (Inflamed Endothelium) Neutrophils trails guide virus-specific CD8+ T cell migration. Chemokine from Uropod of Neutrophils Kihong Lim et al. Science 2015;349:aaa4352 Published by AAAS Neutrophils trails guide virus-specific CD8+ T cell migration. (CXCL12 is a chemokine: chemical agent attracting cell movement) Virus-specific Cytotoxic T-Cell Blebs containing CXCL12 from Uropod (Trailing membrane region) of Neutrophil “Bread-crumb” trail Kihong Lim et al. Science 2015;349:aaa4352 Cytotoxic T-Cell migration through trachea to virus-infected cells Published by AAAS Please put away all notes and any devices except for your Turning Point NXT Transmitter. No papers or computers on your desk please. No communication between or among students. Response Counter 0% 0% 1. 2. 0% 0% 0% 0% 0% 0% 3. 4. 5. 6. 7. 8. Response Counter 0% 0% 0% 0% 0% 0% 0% 0% 0% 1. 2. 3. 4. 5. 6. 7. 8. 9. Rank 1 2 3 4 5 6 Responses 0% 0% 1 2 0% 0% 3 4 0% 0% 5 6 Reset System to Anonymous How Well Are You Following What is Being Presented so Far in theCourse? (This will be set to anonymous so you will not be identified and your response will not be graded) 1. 2. 3. 4. 5. I’m totally lost. I’m having hard time, but I follow some of it. I’m OK. I can figure most of it out later. I’m following very well. There is no problem with the level of the course. This isn’t pitched at a level appropriate for an upper division undergraduate course. Please move to a higher level of challenge. 0% 0% 0% 0% Response Counter 1. 2. 3. 4. 0% 5. On a scale from –2 to +2 (Use #1 on Key-pad) -2 = I’m lost; 5 (Use #2 on Key-pad) -1 = I’m having a hard time, but I follow some of it. (Use #3 on Key-pad) 0 = I’m doing OK. I uderstand most of it. I can figure the rest out later. (Use #4 on Key-pad) +1 = I’m following OK. No problem (Use #5 on Key-Pad) +2 = This is pretty straight-forward, Please move on. 4 3 2 1 Duration: 0 Seconds Slides Beyond this Point Not included in BIO447, Fall, 2016 Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Or search “Kuby Immunology”, Click on “Kuby Immunology 6e” , go to Student Resources Chapter 2: Cells Cell Death (Also chapter 10) Chapter 11: Signal Transduction Chapter 13: Leucocyte Extravasation Actin Cytoskeleton Linkage to Collagen Extra-cellular Matrix Figure 19-14 ECB 1998, p. 603 Collagen Fibronectin Integrin Plasma Membrane Actin Microfilament MFtoECM Tissue-target Cells in Red Leucocyte CAM in Blue CAMFamly On Endothelial Cells On Neutrophils On Mucosal Epithelium On Leucocytes On Endothelial Cells On Leucocytes CamFamly On Endothelial Cells Families of Cell Adhesion Molecules Kuby, 3rd Ed. Figure 15-2b Animations Produced for Kuby Immunology OnLine Link http://bcs.whfreeman.com/immunology6e/ In Class Use Book CD: Chapter 2: Cells of the Immune-system (Static) Cell Death : (Animated) Chapter 11: Signal Transduction (Animated) Chapter 4 : Immunoglobulins (Static) Chapter 13 Animation. Leukocyte Extravasation (Animated) Response Counter 0% 0% 1. 2. 0% 0% 0% 0% 0% 0% 3. 4. 5. 6. 7. 8. CD Antigen Table CDMarks CD Antigens Color Coded