Download BIO 208 - Genetics - Bishop`s University

BISHOP’S UNIVERSITY
WINTER 2015
BIO 208 - Genetics
Instructor
Estelle Chamoux, PhD
Office: Johnson 310
Phone: 819-822-9600 #2555
Email: [email protected]
Schedule
• Lectures MW, 8:30-10:00, Nichols 2
• Office hours: MW, 10:00-12:00 or by appointment
Textbook
• Concepts of Genetics by Robert J. Brooker
• Use the material provided on Moodle (course slides, assigned readings)
About the format of this course
• Extensive research published in the past years has clearly shown that students learn and
retain better if they take an active part in their own learning. It’s also been clearly
established that active learning activities help students to visualize, conceptualize and
understand how things are made and how they work. Academic achievement is improved in
all the studies comparing courses taught with active learning to those made of traditional
lectures only
• While we will still have several traditional lectures, we will leave a great room for active
learning. Active learning activities will include a lot of different things from simulations,
reproduction of experimentations, case-studies, problem solving, flipped classes (where you
teach the class), team work... In other words, you will to create yourself a lot of your learning
material, that best fits your learning style. I will help you to figure out which learning style
works best for you by exposing you to several techniques and by encouraging collaboration
and team work.
Evaluation
•
Item A: Involvement, participation and engagement in your learning experience: 25%
•
Item B: Understanding and developing problem-solving skills: 25%
•
Item C: Long-term retention of knowledge and problem solving skills: 50% Detailed description of the grading items PAGE 1 ON 4
BISHOP’S UNIVERSITY
WINTER 2015
• Item A: Undergraduate education is not only a matter of getting knowledge, it is
much more than this. Post-graduate institutions, professional schools and employers
are now looking for people with certain skills and attitude more than for people who
know a lot of things. Item A will assess your attitude in class and outside of the
classroom, it will evaluate your capacity to collaborate with others and use material
in order to build your knowledge, and will tell how much you value your learning
experience by being involved in your own education. Item A will be evaluated using
the followings:
• Answering clicker questions - whatever the answer - will count in your
participation mark (the more you answer, the greater the mark). It will also be a
fair representation of your attendance. Optional quizzes available on Moodle
will also count for participation. Up to 15% can be obtained with the clicker
questions and Moodle quizzes for participation.
• Worksheets/summary sheets will have to be filled during/after active learning
activities or lectures. I may also ask some specific clicker questions or ask
short questions to be answered on Moodle. Worksheets, Moodle and clicker
questions for activities will give you up to 5% of the final mark.
• Remember that active learning activities will require that you read or watch
learning material before coming to class. If you find interesting material on the
web while reading, you can also post it or discuss material with your
classmates in the Moodle forum for students. Being active and sharing your
discoveries and ideas can grant another 5%. • Item B: Case-studies or problems will be given to be solved at home or in class.
Some will require that you read material before class, other will require internet
research to be done at home. In class, we will spend time in solving problems and in
learning strategies that should help you to become autonomous. Your answers to
problems or cases-studies will be graded. Because part of them will be done in
class, attending classes will definitely help to increase your mark in this item. The
weighted average of marks obtained for problems and case-studies will count for
25% of your final grade. • Item C will assess the long-term retention of knowledge and skills developed during
lectures, active-learning activities and problem-solving sessions. This will be
evaluated with 2 in-class exams, one in the middle of the term (Feb 25th), the second
one during the final-exams time period at the end of the year. The first exam will last
1h15 and will count for 20%; the final exam will last 2h30 and will count for 30%.
• Mid-term exam: will cover all the material seen in class or in assigned readings
up to one week before the mid-term. The exam will address knowledge and
retention of class material with short-answer, definitions, true-false, mutliple
choice, fill-in-the-blank and/or matching questions. Problem-solving skills and
understanding will also be addressed in the exam (roughly 50%).
• Final exam: Same format as the mid-term. Unless otherwise mentioned, the
final exam should not be cumulative.
Important notes
• No supplemental examination will be given without proper medical documentation.
There are a lot of opportunities to earn marks with the participation activities. It is
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BISHOP’S UNIVERSITY
WINTER 2015
your responsibility to do them (even if they are optional) when they are given. Lots of
marks can be obtained in class, therefore attendance is important. If you have
medical documentation showing that you are not able to attend classes for an
extensive period of time, it will be important to tell me because I will take this into
consideration. However, this is valid only if you miss a substantial amount of
classes: if you miss only one class, the impact will be minimal.
• Please post all the questions regarding the course on the Moodle forum. Only
personal questions should be sent on my email address. Also, note that I’ll answer
emails only if they follow the minimal standards of politeness in communications
with a professor.
• All the works submitted should comply with the policy on plagiarism of the
university. Whatever the extent of plagiarized material, every offense will be
penalized (from 0 on the assignment to 0 on the course) and reported to the dean
Detailed course content (time permitting)
I. Overview of genetics (chapter 1)
1)Introduction
2)Molecular genetics
3)Genes and traits
4)Fields of genetics
5)Concept of genetic variation and allele frequency
II.Patterns of inheritance
1)Reproduction and chromosome transmission (chapter 2)
i. Chromosomes
ii.Cell division
iii.Mitosis and cytokinesis
iv.Meiosis
v.Sexual reproduction
2)Mendelian inheritance (chapter 3)
i. Mendel’s studies
ii.Law of segregation
iii.Law of independent assortment
iv.Chromosome theory of inheritance
v.Inheritance patterns in humans
vi.Probabilities and statistics
3)Sex chromosomes and sex determination (chapter 4)
i. Mechanisms of sex determination
ii.Dosage compensation and X inactivation in mammals
iii.Properties of X and Y chromosomes in mammals
iv.Transmission patterns for X-linked genes
4)Extensions of Mendelian inheritance (chapter 5)
i. Overview of simple inheritance patterns
ii.Dominant and recessive alleles
iii.Environmental effects on gene expression
iv.Incomplete dominance, overdominance, codominance
v.Sex-influenced and sex-limited inheritance
vi.Lethal alleles
vii.Pleiotropy
viii.Gene interactions
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BISHOP’S UNIVERSITY
WINTER 2015
5)Extranuclear inheritance, imprinting and maternal effect (chapter 6)
i. Extranuclear inheritance: Mitochondria
ii.Epigenetics: imprinting
iii.Maternal effect
6)Genetic linkage and mapping in eukaryotes (chapter 7)
i. Overview of linkage
ii.Relationship between linkage and crossing over
iii.Genetic mapping in plants and animals
iv.Mitotic recombination
III.Variation in chromosome structure and number (chapter 8)
1)Examination of eukaryotic chromosomes
2)Changes in chromosome structure:
i. Deletions
ii.Duplications
iii.Inversions
iv.Translocations
3)Changes in chromosome number
i. Aneuploidy
ii.Polyploidy
4)Mechanisms that produce variation in chromosome numbers
IV.Genetic technologies (selected parts of chapters 14 to 22)
1)To analyze and manipulate DNA
i. Gene cloning using vectors (19.1)
ii.Polymerase chain reaction (19.2)
iii.DNA libraries (19.3)
iv.Analyzing DNA- and RNA-binding proteins (19.4)
v.DNA sequencing and site-directed mutagenesis (19.5)
vi.Genomics: Mapping and sequencing projects (selected parts of 21)
2)To study the expression of genes:
i. Gene transcription, RNA modification and translation (selected parts of 14 &
15)
ii.Gene regulation in eukaryotes (17)
iii.Functional genomics (22.1)
iv.Proteomics (22.2)
v.Bioinformatics (22.3)
3)Biotechnology
i. Use of microorganisms in biotech (20.1)
ii.Genetically modified animals (20.2)
iii.Reproductive cloning and stem cells (20.3)
iv.Human gene therapy (20.5)
V.Population genetics
1)Genes in populations (25.1)
2)Sources of new genetic variation (25.7)
3)Overview of quantitative traits (26.1)
4)Polygenic inheritance (26.3)
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