* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download IMSP Autumn Conference Nov
Survey
Document related concepts
DNA vaccination wikipedia , lookup
Lymphopoiesis wikipedia , lookup
Adaptive immune system wikipedia , lookup
Immune system wikipedia , lookup
Polyclonal B cell response wikipedia , lookup
Molecular mimicry wikipedia , lookup
Adoptive cell transfer wikipedia , lookup
Sjögren syndrome wikipedia , lookup
Cancer immunotherapy wikipedia , lookup
Innate immune system wikipedia , lookup
Autoimmunity wikipedia , lookup
Immunosuppressive drug wikipedia , lookup
Transcript
IMSP Autumn Conference Nov. 29th to Dec. 1st 2002 in Greifswald Different hypersensitivities –pathophysiology and therapeutical approaches Lecture by Prof. Dr. C. Schütt, Head of the Department of Immunology at the Institute of Immunology and Transfusion Medicine, University of Greifswald In the first lecture of the weekend Prof. Schütt gave a short summary of the organs and cells of the immune system and their special functions. She explained how the different cells normally work together. After this introduction she spoke about pathogenic immune reactions which are called hypersensitivities. There are four types of hypersensitivities that have very different effects on the human body. Type 1 is mediated by IgE and its influence on mast cells. A person suffering from allergies produces much more IgE then a healthy person. The IgE binds on receptors located on mast cells and granulocytes. Contact with allergenes such as dust mites, hay, furry animals etc. causes a crosslinking of the IgE receptors and mast cell degranulation. This leads to different inflammatory effects on the whole body. Asthma bronchiale for the most part belongs to this type of allergy. Therapies are avoidance of contact to the allergen and most important desensitization. Children who grow up with animals and other allergenes are less likely to develop an allergy thanks to early desensitization. Type 2 is the cytotoxic type and can be found in autoimmune diseases and drug allergies. It is difficult to find a therapy for this type and up to now there is no appropriate treatment. Type 3 is the type of soluble immune complexes like allergic alveolitis. In this case desenzitization is contraindicated. Type 4 is T-cell mediated and causes non-specific inflammatory reactions. It is found at some autoimmune diseases like multiple Sklerose and juvenile Diabetes mellitus. To close the lecture Prof. Schütt gave us an outlook to “castles in the air” of immune science. Perhaps one day it will possible to get a specific tolerance induction for every patient. (Simone Stäcker, 5th semester) http://www.medizin.uni-greifswald.de/imsp