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Allergy and Hypersensitivity K. J. Goodrum 2006 Types of Immune Hypersensitivity Reactions Types of Immune Hypersensitivity Reactions Properties of Inhaled Allergens Penetration of epithelial Barriers by Allergens Early IL-4 response promotes Th2 development that drives B cell class switching to IgE Signaling through Stat6 is necessary for Th2 responses. Th2 cells support IgE responses. Antigen binding to IgE on mast cells leads to amplification of IgE production Mast cell activation affects many tissues Molecules released upon activation of mast cells Molecules released upon activation of mast cells Toxic granule proteins and inflammatory substances released upon activation of eosinophils Toxic granule proteins and inflammatory substances released upon activation of eosinophils Acute vs. late phase inflammatory responses TH2 mediated chronic inflammation in Asthma Treatment approaches for IgE-mediated Allergy Type II Cytotoxic reaction Immune Complex mediated local inflammation such as in Arthus Reaction Serum Sickness: an Immune complex disease Type IV Hypersensitivity Reactions Stages of a Type IV Hypersensitivity Reaction Th1 derived cytokines and chemokines direct Type IV reactions Allergic Contact Dermatitis: A type IV reaction Blistering skin lesions on hand of patient with poison ivy contact dermatitis (a type IV reaction) Granulomatous inflammation is a consequence of chronic Type IV reactions
