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Chapter 7, Part 2 - ANSWER KEY TO ACTIVITIES ACTIVITY 1: Match the statements with the type of hypersensitivity being described. a. type I b. type II c. type III d. type IV B 1. Immune system attacks the body’s own antigens. D 2. Damage is due to T cells and macrophages attacking the target. C 3. Due to antigen-antibody complexes that deposit in blood vessels. A 4. Involves IgE and mast cell degranulation. D 5. Does not involve antibodies. A 6. Can cause anaphylactic shock. ACTIVITY 2: Answer the following questions. 1. What body cells are responsible for triggering most of the symptoms of allergies? Mast cells 2. What areas of the body have the highest numbers of this type of cell? Areas under the skin and mucous membranes (like the GI and respiratory tract). ACTIVITY 3: Answer the following questions. 1. Which type of hypersensitivity reaction is NOT involved in autoimmunity? Type I: IgE-mediated Hypersensitivity 2. Which TWO types of hypersensitivity reaction are involved in lupus (SLE)? Type II (there is production of autoantibodies against a wide variety of self antigens) and Type III (circulating immune complexes are deposited in kidneys, brain, heart and other organs) ACTIVITY 4: Which of the following do the statements below best apply to? a. ABO blood group b. Rh blood group c. Both B 1. There are only two phenotypes – presence of antigen or absence. A 2. Antibodies against other types are present before first exposure to other types. C 3. Mismatches can cause clinical problems. C 4. Presence of antigen is genetically dominant to absence.