Download ERYTHROPOIESIS Erythropoiesis: is the formation of red blood

ERYTHROPOIESIS
 Erythropoiesis:
 is the formation of red blood cells, i.e.,
the developmental processes of the red
blood cell.
 occurs in the red bone marrow from the
descendants of the proerythroblast stem
cell by the processes of proliferation
and differentiation
 each hemocytoblast stem cell can give
rise to as many as 211 mature cells.
 Proerythroblast is:
 also called a pronormoblast
 the earliest stem cell (derived from the
hemocytoblast = pluripotent
hemopoietic cell)
 found in the red bone marrow which is
committed to develop into a red blood
cell.
Pronormoblast or Proerythroblast
Basophilic Normoblast (Erythroblast)
Polychromatic / Polychromatophilic
Erythroblast / Normoblast
Orthochromatic/Orthochromatophilic
Erythroblast/Normoblast
Polychromatophilic Erythrocyte or
Reticulocyte (Retic)
Erythrocyte (Red Blood Cell- RBC)
SEM (Scanning Electron Microscope)
Views of Reticulocytes and RBC’s
Reticulocyte
Erythrocyte
Erythropoiesis – All Stages
 Hemopoietic Growth Factor is:
 any of the various regulatory proteins
and local hormones which:
▪ target the hematopoietic stem cells
in the red bone marrow
▪ promote the growth, organization,
and maintenance of red bone
marrow and blood cells.
 Erythropoietin is:
 also referred to as EPO
 a glycoprotein hormone which
stimulates the production of red blood
cells by stem cells in the red bone
marrow.
 produced mainly by the kidneys
 released in response to decreased levels
of oxygen detected in the blood in the
kidney nephron
Negative Feedback Regulation of Erythropoiesis