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INDÚSTRIA, COMÉRCIO E EXPORTAÇÃO LTDA. FILCORTEX VEG VECTORIZED BIOACTIVE REPLACES PROTEINS OF THE HAIR CORTEX REPAIRS BRITTLE AND DAMAGED HAIR REPLACES HAIR MASS AFTER 1 TREATMENT CYCLE Hair is an extremely complex and sophisticated composite, where different proteins are combined with lipids and minerals to form a unique structure with extraordinary properties. Hair macrostructure consists of an outer cuticle, an inner cuticle, an inner cortex and occasionally a central medulla. The cortex is the thickest hair layer, and is made of long cells joined together by an intercellular cement made of proteins and lipids. Each cortical cell is filled with bundles of keratin fibers, or Keratin Intermediate Filaments (KIFs). Recent findings based on highly sensitive proteomic analytical tools show that human KIFs are composed by acid (type I) and neutral (type II) keratins, organized in bundles: Each keratin forms structures in form of a spiral a-helix twisted in pairs that form larger structures called PROTOFIBRILS. Those, in turn, are organized in groups of FOUR PROTOFIBRILS, forming structures further reinforced, known as FIBRILS. FIBRILS The empty spaces of these complex structures are filled with proteins, known generically as KERATIN ASSOCIATED PROTEINS, or KAPs. KAPs are composed of over 100 proteins with different structures that can be grouped in 26 different families, belonging to 3 different groups that play different roles in hair. Two groups - High Sulfur KAPs - contain large amounts of sulfur-containing aminoacids such as cysteine, are able to form strong covalent bonds and bridges between Keratin Intermediate Filaments. A third group is low in sulfur, and is known as the HGT (HIGH GLYCINE-TO-TYROSINE) group. HGT KAPs are responsible for the adhesion among the macrofibrils and between the cortex and the cuticles, adding flexibility and resistance to the fibers. KAPs belonging to the HGT group are more soluble and less resistant against chemicals and environment aggression than keratin and sulfur-rich KAPs, and thus are the first proteins to be damaged and removed with chemical treatments such as straigthening, bleaching or dyeing. Such treatments damage or remove HGT KAPs and cause a decrease in cohesion among the matrix proteins, leading to fragility and brittleness on the hair. FILCORTEX VEG REPLACES PROTEINS OF THE HAIR CORTEX VECTORIZED BIOACTIVE REPLACES HAIR MASS AFTER 1 TREATMENT CYCLE FILCORTEX VEG is the result of the association of hair proteomics with biocomputing tools and associates the amino acids of the HGT KAPs with an exclusive Cuticle Interlock System - CIS which seals the amino acids into the hair fiber, increasing hair mass and reinforcing its structure. PROOF EFFECT ON THE CORTEX Tresses submitted to one treatment cycle TRAT (shampoo+conditioner+mask) showed significantly lower cortical fluorescence intensity (1.9 times) in relation to strands in CTRL treatment. When a product with high substantivity is applied to hair, there is a connection between the active ingredients and damaged hair sites and thus the number of sites available for binding to the marker dye is reduced. Consequently, the fluorescence intensity is lower. EFFECT ON THE CORTEX EFFECT ON THE SURFACE (CUTICLE LAYER) EFFECT ON THE SURFACE (CUTICLE LAYER) AMINOACIDS PROFILE IN FILCORTEX VEG AMINOACID DISTRIBUTION (%) arginine aspartic acid cystine glutamic acid glycine hystidine isoleucine leucine lysine methionine phenilalanine proline serine threonine tryptophan tyrosine valine 6.61 9.93 1.64 13.65 23.14 2.46 4.22 7.27 4.77 1.49 4.63 3.88 4.45 3.70 0.28 2.79 5.05 USAGE LEVEL PRODUCT % Shampoo 1.0 to 3.0 Conditioner, Leave-in conditioner, Hair mask, Hair serum 1.5 to 3.0 INCI Name. Water (and) Kappaphycus Alvarezii Extract (and) Laminaria Saccharina Extract (and) Hydrolyzed Rice Protein (and) Hydrolyzed Soy Protein (and) Glycine Check the available preservative systems Tel. +55 21 2591-4345 / +55 21 9 8102-4938 www.assessa.com.br [email protected]