Download Slide () - Journal of Speech, Language, and Hearing Research

From: Biotechnology in the Treatment of Sensorineural Hearing Loss: Foundations and Future of Hair Cell
Regeneration
J Speech Lang Hear Res. 2011;54(6):1709-1731. doi:10.1044/1092-4388(2011/10-0149)
Legend:
Plasticity in the mammalian organ of corti. The ability of the mammalian cochlea to produce hair cells after normal cochlear development
suggests that the organ of Corti maintains the proper cell types required for hair cell regeneration. Panel A: In the mouse cochlea, hair cells are
normally developed by 14 days after fertilization. Red cell = one row of inner hair cells (IHC); blue cells = three rows of outer hair cells (OHC).
Panel B: Culturing the organs of Corti in the presence of retinoic acid, a mitotic agent that induces cellular proliferation and results in the
production of supernumerary hair cells (Kelley et Copyright
al., 1993).©The
x-axis labels,
“−Retinoic acid” and “+Retinoic acid,” indicate the absence of and
American
Speech-Languagepresence
of
retinoic
acid,
respectively.
Date of download: 5/9/2017
Hearing Association