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Neural progenitor cells have different modes of division. A. Temporal sequence of neurogenesis in the mouse cerebral cortex. Neurons begin to
accumulate in the cortical plate (CP) during the last 5 days of embryonic development. Within the cortical plate neurons populate the deep layers before
settling in the superficial layers. (MZ, marginal zone; PP, preplate; SP, subplate; IZ, intermediate zone; SVZ, subventricular zone; VZ, ventricular zone;
WM, white matter.)
B. Asymmetric and symmetric modes of cell division. A progenitor cell (P) undergoes asymmetric division to generate a neuron (N) and a glial cell (G)
(left). A progenitor
undergoes and
asymmetric
division,
giving Principles
rise to another
progenitor
and
a neuron. This mode of division contributes to the
Source:cell
Differentiation
Survival of
Nerve Cells,
of Neural
Science,cell
Fifth
Editon
generation of neurons at early stages of development, and of glial cells at later stages, typical of many regions of the central nervous system (middle). A
Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available
progenitor cell undergoes symmetric division to generate two additional progenitor cells (right).
at: http://mhmedical.com/ Accessed: May 11, 2017
C. Time-lapse
cinematography
captures theEducation.
divisions and
differentiation
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reservedof isolated cortical progenitor cells in the rodent. Lineage diagrams illustrate cells
that undergo predominantly asymmetric division, giving rise to neurons (left), or symmetric division that gives rise to oligodendrocytes (right). (Modified,