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1. Extra 10 will cause
a. Will divert to Th2 (because inhibits 12, but something says, if you add 10,
goes to Tr1)
2. IL-12 diverts to
a. T1
b. T2
3. Sufficient IL4 for autocrine and to help others will impact which pathway
a. Th2
b. Tr1
c. Th1
d. Th3
4. Sufficient IL2 for autocrine and to help others will impact which pathway
a. Tr1
b. Th2
c. Th1
d. Th3
5. Theory of hygiene is
6. what doesn’t participate in the allergic response
a. prostaglandin
b. IgE
c. IL4
d. Histamine
e. Mast cells
7. What does Cyclosporine not cause
a. Increase TGF
b. Increase in neutrophils
c. Not decrease in leukofein
d. Decrease in IL-2
8. CD8 works on
a. Bacteria only
b. Virus only
c. Virus and cancer where the DNA is internal
9. which is true
a. hemopoietic pluripotent stem cells can make RBC
b. common lymphoid progenitor can also make NK
c. common lymphoid progenitor cells can make monocytes
10. The repoirtoire of MHC enables
a. Strong response in many cases
b. Evolutionary strong response to self antigen and weak to virus and
bacteria
c. Evolutionary of strong response to virus and bacteria where there is crossreacting with self antigens
11. CD8 kills by
a. Unlike NK not by granzyme and perforin
b. Receptors and injection
12. What is involved in macrophage and virus activation of dendritic cells
a. Toll receptors
b. CD40L
13. mannose binding lectin is involved
a. activating the complement system
b. adaptive immunity (it’s innate)
c. opsonization
14. N and P sequences are
a. Part of the RSS system
b. ???
15. RSS 12/23 rule is
a. 12 and 23 long nucleotides only
b. 12 on light chain and 23 on heavy chain for joining
c. 12 and 23 with heptamer and nonamers also
16. recent theory about newborn immune response
a. T cells aren’t mature
b. B cells aren’t mature
17. MHC1 functions in killing
a. Using the FAS and FAS-ligand
b. Apoptosis
c. Both
18. NK is activated by
a. Decrease in MHC1
b. Increase in MHCI
c. Increase in MHCII
d. Decrease in MHCII
19. Something about MHC I
a. T helper
b. CTL
20. Absence of invariant (constant) portion of AB will cause
21. Number of recombinations in kappa light chain is determined by
a. TdT
b. D region
c. J region
d. Direction of frame reading
22. Positive selection in the thymus is impacted by
a. Signals alone
b. Self-antigen or something like that
23. Difference between mature and naïve T cells is in
a. Life span
b. Rate to move to peripheral tissue
c. Rate of response
24. T cells are only activated
a. After there is TCR
b. TCR exist in the beginning…
c. Clonal expansion
25. What is activated without specific activation
a. CD25
b. Th1
c. Th2
d. Tr1
e. CD8
26. What isn’t involved in immune response
a. CD25
b. Th1
c. Th2
d. CD16
e. B cells
27. Mouse with -/- for IL 10 gets spontaneous Chrone’s disease. What is this
connected to
28. peripheral tolerance
29. quantitative and qualitative secondary immune response is a function of
a. initial T cell response
b. rate of tissue perfusion
c. B cell ____
30. AIRE: autoimmune regulator
a. Controls expression…
b. Impacts autoimmune diseases
c. Something about promiscuity and maturation
31. Decrease in CTLA-4 will cause
32. IgG1 and IgG2 are different
a. Isotypes
b. Allotypes
c. Idiotypes
33. Something about IgE and hypersensitivity
34. Allelic exclusion is expressed
a. Recombinations of a single allele
b. Expression of recombinations of only one type
35. Monoclonal AB comes from
a. Single clone
36. SLE (lupus)
a. Immunocomplexes accumulate
b. Damage in spinal chord
c. Limb paralysis
37. ITP (platelets)
a. Treatment will include macrophages and neutrophils that compete with Fc
38. What isn’t true about the lymph system
a. Closed system
b. Eventually drains to the blood
c. cleans the extracellular spaces
d. lymphocytes made in the primary lymph nodes
e. something abut peripheral lymph nodes
39. attenuated micro-ogranism vs dead one in vaccine
a. attenuated has a stronger response
b. should NOT give attenuated to someone with an immunodeficient disease
c. dead micro-organism cannot cause isotype change
d. made safer with recombinant DNA technology
e. rarely reverts to virulent strain
40. Use of adjuvant
a. Make more immunogenic
b. Increase affinity
c. Something about solubility, have bacterial products
41. IL-1 acts like hormone in
a. Lectin-induced pathway
b. Alternative pathway
42. HIV penetrates
a. Every cell with both CCR5 and CD4
b. Just CCR5
c. Just CD4
43. intensity of IgE expression is a function of
a. Type of allergen
44. liver transplant from parent to child need…
a. blood type, one of MHC’s matching
45. Antigen expressed by MHC-2 is via
a. Initially dendrites, then later by macrophage and B
b. 1st by macrophage and B cells and later by dendrites
c. dendrite only
d. dendrite and B cells but not macrophage
**Questions where one answer choice related to
– “anergy”
– “Th17” (different question)
– Thymic epithelial cells (different question)