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Dear Editor,
We would like to submit the enclosed manuscript entitled “Involement of
PAK1 in RIPX-induced gastric cancer cell migration and invasion”, which we wish to
be considered for publication in oncotarget.
Coordinated regulation of the actin cytoskeleton is responsible for the
formation of protrusive structures that are central to tumor cell migration and
invasion, including filopodia, lamellipodia and invadopodia. RIPX was reported
to play an important role in neuronal development, whereas the role of RIPX in
cancer has not been explored. Here, first, we demonstrate that RIPX localizes in
F-actin-enriched invadopodia and induces the formation of protrusive structures.
Importantly, we found that the overexpression of RIPX promotes gastric cancer
cell migration and invasion. Furthermore, p21-activated kinase 1 (PAK1) is
involved in RIPX-induced SGC-7901 cell migration and invasion by regulating
its expression. Moreover, we showed a positive correlation between PAK1 and
RIPX expression in gastric cancer samples. Strikingly, we found that high
expression of RIPX is tightly correlated to clinical gastric cancer. These findings
revealed a novel function of RIPX in gastric cancer, suggesting that blocking
PAK1-RIPX might be a potential therapeutic strategy for metastasis of gastric
Meanwhile, we also declare that there are no conflicts of interests and the
content of the study is original and that it has not been published or accepted for
publication, either in whole or in part, in any form (other than as an abstract or
other preliminary publication). All the authors also declare that no part of the
manuscript is currently under consideration for publication elsewhere.If you
have any questions, please don't hesitate to contact us.
I am looking forward to hearing from you soon.
Sincerely yours
Guiling Wang&Feng Li
Department of Cell Biology,
Key Laboratory of Cell Biology of Mini stry of Public Health of
China,China Medical University,Shenyang 110001, P.R. China
E-mail: [email protected]& [email protected]
May 8, 2013