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Gastric Cancer Dr. Belal Hijji, RN, PhD February 1, 2012 Learning Outcomes At the end of this lecture, students will be able to: • Explain the pathophysiology of gastric cancer and its clinical picture. • Describe assessment and diagnostic evaluation of gastric cancer. • Discuss the medical management of gastric cancer. • Discuss the nursing process for the care of a patient with gastric cancer. 2 Pathophysiology • Gastric cancers can occur anywhere in the stomach. However, most frequently, they occur on the lesser curvature (next slide). • The tumor infiltrates the surrounding mucosa, penetrating the wall of the stomach and adjacent organs and structures. • At the time of diagnosis, the liver, pancreas, esophagus, and duodenum are often affected. 3 Clinical manifestations • Pain relieved by antacids. • Dyspepsia (indigestion), early satiety ()تخمة, weight loss, abdominal pain above the umbilicus. • Loss of appetite and nausea and vomiting. 4 Assessment and diagnostic findings • The physical examination may not be helpful in detecting the cancer because most early gastric tumors are not palpable. In advanced cases, a gastric mass may be palpable. • Ascites and hepatomegaly may be apparent if metastasis occurs. • Palpable nodules around the umbilicus (slide 6). • Esophagogastroduodenoscopy for biposy and cytologic washings is the diagnostic study of choice. • CT completes the diagnostic studies to assess for surgical resectability of the tumor before surgery is scheduled. • CT of the chest, abdomen, and pelvis is important in staging of gastric cancer. 5 Sister Mary Joseph's nodule of the umbilicus 6 Medical management • Successful treatment of gastric cancer is through tumor removal. • Cure could be achieved if the tumor has been removed while it is still localised to the stomach. Otherwise, cure is less likely. • Unresectable tumor in a patient with advanced disease, chemotherapy using single agent chemotherapeutic medications including 5-fluorouracil (5-FU), cisplatin, doxorubicin, and mitomycin. • It is now more common to administer combination therapy, primarily 5-FU-based therapy with other agents. 7 • Total gastrectomy may be performed for a resectable cancer. The entire stomach, the duodenum, the lower portion of the esophagus, supporting mesentry, and lymph nodes are removed. Esophagojejunostomy is performed to reconstruct the GI tract. 8 Nursing process For a patient with gastric cancer Assessment • Ask patient about loss of weight, how much and over what period of time. Ask about tolerating full diet. If not, what foods s(h)e eats. Does the patient feel full after eating small amount? Is there any pain? Do foods, antacids, or medications relieve pain? The nurse should then perform the physical examination to assess the abdomen for tenderness or masses, palpates the abdomen to detect ascites. 9 Nursing diagnoses, planning and goals • Based on assessment data, nursing diagnoses may include: – – – – – Anxiety related to the disease and anticipated treatment. Imbalanced nutrition related to early satiety or anorexia. Pain related to tumor mass. Anticipatory grieving related to diagnosis of cancer. Deficient knowledge regarding self-care activities. • The major goals for the patient may include: – – – – reduced anxiety optimal nutrition pain relief adjustment to diagnosis and anticipated life style changes 10 Nursing interventions • Reducing anxiety: – Provide a relaxed, nonthreatening atmosphere so that the patient freely expresses his fears, concerns, and possibly anger about diagnosis. – Encourage significant others to support the patient. – Advise the patient about any procedures and treatments so that he knows what to expect. • Promoting optimal nutrition: – Encourage the patient to eat small frequent portions of nonirritating foods that are high in calories and vitamins (A, C) and iron to enhance tissue repair. – Provide parenteral nutrition if prescribed before surgery. 11 – Explain ways to prevent and manage dumping syndrome (rapid emptying of the stomach contents into the small intestine; characterized by sweating and weakness) after surgery. In this condition, the patient has a feeling of fullness, nausea, and diarrhea; this causes dehydration, hypotension, and tachycardia. Therefore: • Encourage the patient to have six small meals daily that are low in carbohydrate and sugar with fluids between, rather than with, meals. Inform the patient that symptoms will often resolve after several months. – Monitor the IV therapy and nutritional status. – Record intake and output and daily weight. – Assess for signs and symptoms of dehydration. 12 • Relieving pain: – Administer analgesics as prescribed – Assess the level of pain – Encourage nonpharmacologic methods for pain relief. • Providing psychosocial support: – Help the patient express fear, concern, and grief about diagnosis. – Answer the patient’s questions honestly, and encourage him to participate in the treatment decisions. – Offer emotional support and involve significant others. 13 Evaluation Expected outcomes may include the following: • Reports less anxiety • Attains optimal nutrition • Has less pain • Performs self care activities and adjust to lifestyle changes • Prepares for the dying process 14