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School funded PhD studentship in Life Sciences Deadline: 13th January Prof Sarah Guthrie Understanding alpha2-chimaerin signalling in the normal and abnormal development of the ocular motor system Eye movements in humans depend on a system of nerves and muscles which rotate the eyeball – the ocular motor system. The correct function of this system depends on the precise navigation of nerves during development; incorrect development leads to eye movement disorders such as squint. Mutations in the signalling molecule alpha2-chimaerin cause squint in humans, and chimaerin plays an important role in wiring the ocular motor system, by controlling the cytoskeleton. This project will explore the signalling networks regulated by alpha2-chimaerin to unravel the mechanisms that cause squint in humans. Candidate proteins identified in a proteomics screen will be tested in a range of assays. Techniques involved will include molecular biology, microinjection, transgenic breeding, imaging and phenotypic analysis in the zebrafish, and neuronal cell culture. This School funded position, which covers fees and a stipend at standard RCUK rates, is open to Home / EU applicants who should hold or expect to obtain a first, or upper second class honours degree (or equivalent) in relevant subject. Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section. Please submit a formal application using our online application system at http://www.sussex.ac.uk/study/pg/applying/, including a CV, statement of interest and names of two academic referees. On the application system use Programme of Study – PhD NEUROSCIENCE. Please make sure you include the project title and supervisor’s name with your statement of interest on the application form.