Download Understanding alpha2-chimaerin signalling in the normal and

School funded PhD studentship in Life Sciences
Deadline: 13th January
Prof Sarah Guthrie
Understanding alpha2-chimaerin signalling in the normal and abnormal development of the ocular
motor system
Eye movements in humans depend on a system of nerves and muscles which rotate the eyeball – the
ocular motor system. The correct function of this system depends on the precise navigation of
nerves during development; incorrect development leads to eye movement disorders such as squint.
Mutations in the signalling molecule alpha2-chimaerin cause squint in humans, and chimaerin plays
an important role in wiring the ocular motor system, by controlling the cytoskeleton. This project will
explore the signalling networks regulated by alpha2-chimaerin to unravel the mechanisms that cause
squint in humans. Candidate proteins identified in a proteomics screen will be tested in a range of
assays. Techniques involved will include molecular biology, microinjection, transgenic breeding,
imaging and phenotypic analysis in the zebrafish, and neuronal cell culture.
This School funded position, which covers fees and a stipend at standard RCUK rates, is open to
Home / EU applicants who should hold or expect to obtain a first, or upper second class honours
degree (or equivalent) in relevant subject. Candidates for whom English is not their first language
will require an IELTS score of 6.5 overall, with not less than 6.0 in any section.
Please submit a formal application using our online application system at
http://www.sussex.ac.uk/study/pg/applying/, including a CV, statement of interest and names of
two academic referees.
On the application system use Programme of Study – PhD NEUROSCIENCE.
Please make sure you include the project title and supervisor’s name with your statement of interest
on the application form.