
Modulation of premotor circuits controlling locomotor activity by
... CSF-cNs are responsive to pH variations and bending of the spinal cord, suggesting that CSFcNs are polymodal sensory neurons able to carry information from distinct sensory cues in a context dependent manner. Furthermore, their remote activation using optogenetics in zebrafish was shown to induce sl ...
... CSF-cNs are responsive to pH variations and bending of the spinal cord, suggesting that CSFcNs are polymodal sensory neurons able to carry information from distinct sensory cues in a context dependent manner. Furthermore, their remote activation using optogenetics in zebrafish was shown to induce sl ...
A transcription factor network controls cell migration
... parapineal organ that, together with the flanking habenular nuclei, form a region of the forebrain called the dorsal diencephalon. Although they are derived from the same anlage, the pineal and parapineal organs comprise distinct neuronal types and perform different functions. The zebrafish pineal o ...
... parapineal organ that, together with the flanking habenular nuclei, form a region of the forebrain called the dorsal diencephalon. Although they are derived from the same anlage, the pineal and parapineal organs comprise distinct neuronal types and perform different functions. The zebrafish pineal o ...
Zebrafish foxd3 is selectively required for neural crest specification
... originating from adjacent ectodermal and mesodermal tissues (Huang and Saint-Jeannet, 2004; Knecht and Bronner-Fraser, 2002). Neural plate border and/or neural crest cells co-express numerous transcription factors, including foxd3, snail/slug, sox10 and tfap2a, that have critical roles in neural cre ...
... originating from adjacent ectodermal and mesodermal tissues (Huang and Saint-Jeannet, 2004; Knecht and Bronner-Fraser, 2002). Neural plate border and/or neural crest cells co-express numerous transcription factors, including foxd3, snail/slug, sox10 and tfap2a, that have critical roles in neural cre ...
Development of Structure and Sensitivity of the Fish Inner Ear
... auditory structures that remain poorly understood across vertebrate taxa. For example, how does auditory reception and its neural processing change during ontogeny? Which morphological changes occur in the inner ear versus the central auditory system that may account for developmental improvements i ...
... auditory structures that remain poorly understood across vertebrate taxa. For example, how does auditory reception and its neural processing change during ontogeny? Which morphological changes occur in the inner ear versus the central auditory system that may account for developmental improvements i ...
The Formation of Terminal Fields in the Absence of Competitive
... Animals. Zebrafish embryos were obtained from a laboratory colony ...
... Animals. Zebrafish embryos were obtained from a laboratory colony ...
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... hindbrain, the facial branchiomotor neurons (FBMNs) undergo a chain-like tangential migration from their birthplace in rhombomere (r) 4 to their final destination in r6/r7. Here, we report that ablation of either the cell body or the trailing axon of the leading FBMN, or ‘pioneer’ neuron, blocks the ...
... hindbrain, the facial branchiomotor neurons (FBMNs) undergo a chain-like tangential migration from their birthplace in rhombomere (r) 4 to their final destination in r6/r7. Here, we report that ablation of either the cell body or the trailing axon of the leading FBMN, or ‘pioneer’ neuron, blocks the ...
Autonomous and nonautonomous functions for Hox/Pbx in
... expression of tag-1 in r4 neurons of 36-hpf lzr/pbx4 embryos (Pöpperl et al., 2000). In addition, the motor nerve projection from r2 appears reduced or missing entirely, and axons from cells located in r2 and r3 project unfasiculated to the lateral edge of the hindbrain where they terminate. These ...
... expression of tag-1 in r4 neurons of 36-hpf lzr/pbx4 embryos (Pöpperl et al., 2000). In addition, the motor nerve projection from r2 appears reduced or missing entirely, and axons from cells located in r2 and r3 project unfasiculated to the lateral edge of the hindbrain where they terminate. These ...
Review Early Steps in the Development of the Forebrain
... this region of our CNS that confers many uniquely human attributes. Despite this, the general organization of the forebrain is conserved in all vertebrates. What makes the brain of each species unique is not the initial presence or absence of different subdomains of the CNS; rather, it is the extent ...
... this region of our CNS that confers many uniquely human attributes. Despite this, the general organization of the forebrain is conserved in all vertebrates. What makes the brain of each species unique is not the initial presence or absence of different subdomains of the CNS; rather, it is the extent ...
hox Gene Regulation and Function During Zebrafish
... Hox discovery and conservation throughout the animal kingdom First characterized in Drosophila melanogaster, Hox genes were identified on the third Drosophila chromosome in two loci, the Antennapedia- and bithorax complexes (ANT-C and BX-C respectively) which makes up the Drosophila Homeodomain comp ...
... Hox discovery and conservation throughout the animal kingdom First characterized in Drosophila melanogaster, Hox genes were identified on the third Drosophila chromosome in two loci, the Antennapedia- and bithorax complexes (ANT-C and BX-C respectively) which makes up the Drosophila Homeodomain comp ...
A transcription factor network controls cell migration
... post fertilization (hpf), resulting in large deficits in all subtypes of pineal cells (Masai et al., 1997); despite the loss of these cells, the parapineal organ can still form in Flh mutants (Snelson et al., 2008a). In contrast, parapineal development is dramatically affected in Tbx2b mutants, whic ...
... post fertilization (hpf), resulting in large deficits in all subtypes of pineal cells (Masai et al., 1997); despite the loss of these cells, the parapineal organ can still form in Flh mutants (Snelson et al., 2008a). In contrast, parapineal development is dramatically affected in Tbx2b mutants, whic ...
The habenular nuclei - Philosophical Transactions of the Royal
... the posterior commissure and the habenular commissure runs between them ( Nieuwenhuys et al. 1998; Butler & Hodos 2005). In mammals, the habenular complex comprises two separate nuclei on each side: the ‘medial’ (MHb) and ‘lateral’ (LHb) habenulae. The LHb is further subdivided into principal medial ...
... the posterior commissure and the habenular commissure runs between them ( Nieuwenhuys et al. 1998; Butler & Hodos 2005). In mammals, the habenular complex comprises two separate nuclei on each side: the ‘medial’ (MHb) and ‘lateral’ (LHb) habenulae. The LHb is further subdivided into principal medial ...
Jesús Pujol Martí Neural map organization and development in the lateral-line system
... functionally complex, mediating contrasting behaviours that are also present in the adult fish. A decade ago, Ghysen‟s research group showed that the lateralis (lateral-line) sensory neurons display a topographic neural map. The same group shed some light on when and how this map is established. Sin ...
... functionally complex, mediating contrasting behaviours that are also present in the adult fish. A decade ago, Ghysen‟s research group showed that the lateralis (lateral-line) sensory neurons display a topographic neural map. The same group shed some light on when and how this map is established. Sin ...
Moving the Shh Source over Time: What Impact on Neural Cell
... The functional complexity of the vertebrate central nervous system is reflected by the large variety of neurons that form complex processing networks but also by the diversity of their indispensable glial cell partners, mainly composed of astrocytes and oligodendrocytes. Generation of this large arr ...
... The functional complexity of the vertebrate central nervous system is reflected by the large variety of neurons that form complex processing networks but also by the diversity of their indispensable glial cell partners, mainly composed of astrocytes and oligodendrocytes. Generation of this large arr ...
The neuroepithelial basement membrane serves as a boundary and
... intensity projection of a confocal Z-stack of a tg(hoxb1aBAC:mRFP1); tg(isl1:GFP) double transgenic embryo at 48 hpf reveals that most Isl1:GFP positive neurons in both r6 and r7 are also hoxb1a:RFP positive, indicating that they were born in r4. (B) A single XY section of a tg(zCREST1: memb-mRFP1); ...
... intensity projection of a confocal Z-stack of a tg(hoxb1aBAC:mRFP1); tg(isl1:GFP) double transgenic embryo at 48 hpf reveals that most Isl1:GFP positive neurons in both r6 and r7 are also hoxb1a:RFP positive, indicating that they were born in r4. (B) A single XY section of a tg(zCREST1: memb-mRFP1); ...
Characterisation of the zebrafish cerebellar efferent system
... neurons that expressed olig2:GFP. Despite originating in the ventricular zone (VZ), which is known to give rise to inhibitory GABAergic neurons of the cerebellum, such ECs were found to be glutamatergic as they expressed vesicular glutamate transporter 2.1, but not GAD67. Development of this neurotr ...
... neurons that expressed olig2:GFP. Despite originating in the ventricular zone (VZ), which is known to give rise to inhibitory GABAergic neurons of the cerebellum, such ECs were found to be glutamatergic as they expressed vesicular glutamate transporter 2.1, but not GAD67. Development of this neurotr ...
Amo, Neuron, 2014
... classical fear conditioning. It has already been shown that both larval zebrafish and adult goldfish can learn the classical fear conditioning under the situations where the body movements are restricted (Aizenberg and Schuman, 2011; Yoshida et al., 2004). We examined how the learning affected the r ...
... classical fear conditioning. It has already been shown that both larval zebrafish and adult goldfish can learn the classical fear conditioning under the situations where the body movements are restricted (Aizenberg and Schuman, 2011; Yoshida et al., 2004). We examined how the learning affected the r ...
View - OhioLINK ETD
... behavior in zebrafish was dictated by oxygen conditions for days 0-30. Physiology, however, was influenced most by oxygen conditions for days 30-90. The fourth part of my research focused on the consequences of changing food rations of zebrafish size and swimming ability. I found that fish raised u ...
... behavior in zebrafish was dictated by oxygen conditions for days 0-30. Physiology, however, was influenced most by oxygen conditions for days 30-90. The fourth part of my research focused on the consequences of changing food rations of zebrafish size and swimming ability. I found that fish raised u ...
292(1):94-106
... highlights that distinct locations along the brain tube midline appear to remain shut. We have termed this a defect in ‘‘midline separation’’. After neurulation in wildtype zebrafish, the neural tube is closed but shows a distinct midline (Lowery and Sive, 2004). Subsequently, the tube opens at the ...
... highlights that distinct locations along the brain tube midline appear to remain shut. We have termed this a defect in ‘‘midline separation’’. After neurulation in wildtype zebrafish, the neural tube is closed but shows a distinct midline (Lowery and Sive, 2004). Subsequently, the tube opens at the ...
Imaging the Functional Organization of Zebrafish
... above threshold for escapes. Stimuli that were well above threshold sometimes produced responses in both Mauthner cells, possibly as a consequence of the generation of multiple escapes. In these experiments, we purposely did not paralyze the fish so that we could visually monitor its behavior. One c ...
... above threshold for escapes. Stimuli that were well above threshold sometimes produced responses in both Mauthner cells, possibly as a consequence of the generation of multiple escapes. In these experiments, we purposely did not paralyze the fish so that we could visually monitor its behavior. One c ...
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... decision to form one AWCON and one AWCOFF (Bauer Huang et al., 2007). By contrast, the calcium-regulated signaling cascade that comprises the unc-43 CaMKII, the tir-1 adaptor protein and the nsy-1 MAPKKK acts cell-autonomously to repress str-2 gene expression regardless of the state of the AWC on th ...
... decision to form one AWCON and one AWCOFF (Bauer Huang et al., 2007). By contrast, the calcium-regulated signaling cascade that comprises the unc-43 CaMKII, the tir-1 adaptor protein and the nsy-1 MAPKKK acts cell-autonomously to repress str-2 gene expression regardless of the state of the AWC on th ...
Activation of the hypothalamic feeding centre upon visual
... survived laser-ablation. Bilateral ablation of the pretectum dramatically reduced activity in the ILH (Fig.3e, Supplementary Fig.12). These results suggest a functional connection between the 119B-pretectal cells and the ILH, although the connectivity may not be necessarily all direct, but it could ...
... survived laser-ablation. Bilateral ablation of the pretectum dramatically reduced activity in the ILH (Fig.3e, Supplementary Fig.12). These results suggest a functional connection between the 119B-pretectal cells and the ILH, although the connectivity may not be necessarily all direct, but it could ...
Spinal motor neurons are regenerated after
... motor neuron regeneration (see above). However, no mCherry+ cells were observed for up to 8 dpf (n = 7, data not shown). In addition, at two weeks after a spinal lesion in adult Tg(mnx1:Gal4, UAS:nfsB-mCherry) fish (n = 3), we observed small strongly Hb9 immunoreactive cells, previously shown to be ...
... motor neuron regeneration (see above). However, no mCherry+ cells were observed for up to 8 dpf (n = 7, data not shown). In addition, at two weeks after a spinal lesion in adult Tg(mnx1:Gal4, UAS:nfsB-mCherry) fish (n = 3), we observed small strongly Hb9 immunoreactive cells, previously shown to be ...
Visually induced and spontaneous behavior in the zebrafish
... motor actions influence sensory perceptions just as much as the other way around. Animals are continuously relying on sensory feedback to adjust motor commands. On the other hand, behavior is not only induced by the sensory environment, but can be generated by the brain’s rich internal dynamics. My ...
... motor actions influence sensory perceptions just as much as the other way around. Animals are continuously relying on sensory feedback to adjust motor commands. On the other hand, behavior is not only induced by the sensory environment, but can be generated by the brain’s rich internal dynamics. My ...
Spatial distribution and characterization of non
... raised at 28.58C in fish water. After 20– 24 h post-fertilization (hpf ) embryos were maintained in fish water or E2 medium containing 0.003% 1-phenyl-3-(2-thiazolyl)-2-thiourea (PTU; Sigma) to prevent pigment formation. ...
... raised at 28.58C in fish water. After 20– 24 h post-fertilization (hpf ) embryos were maintained in fish water or E2 medium containing 0.003% 1-phenyl-3-(2-thiazolyl)-2-thiourea (PTU; Sigma) to prevent pigment formation. ...
Neural degeneration mutants in the zebrafish, Danio
... neurons. Recent analysis of these processes in vertebrates has been aided by the cloning of homologous genes known to be involved in invertebrate nervous system development. In some cases, functions of cloned genes can be assessed by generating gene knock-out mice (reviewed by Joyner and Guillemot, ...
... neurons. Recent analysis of these processes in vertebrates has been aided by the cloning of homologous genes known to be involved in invertebrate nervous system development. In some cases, functions of cloned genes can be assessed by generating gene knock-out mice (reviewed by Joyner and Guillemot, ...
Zebrafish

The zebrafish (Danio rerio) is a tropical freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes. Native to the Himalayan region, it is a popular aquarium fish, frequently sold under the trade name zebra danio. The zebrafish is also an important and widely-used vertebrate model organism in scientific research, and was the first vertebrate to be cloned. It is particularly notable for its regenerative abilities, and has been modified by researchers to produce several transgenic strains.