Download Functional Annotation of Animal Genomes (FAANG)

Functional Annotation of Animal Genomes
(FAANG)
Ravi N. Ravindranath, Ph.D.
Fertility and Infertility Branch
Eunice Kennedy Shriver
National Institute of Child Health and Human Development
National Institutes of Health
Is FAANG important for NIH?
Associating sequence variation with quantitative
phenotypes has been done in domestic animals
for a few decades because of the importance of
animals :
• As food sources
• Models for human health/disease
• Ecology
Exploring Horizons for Domestic
Animal Genomics
• Meeting was held at NAS in 2002
• NIH perspective at the Meeting:
• Sequencing is essential for basic scientific
understanding
• Sequencing is essential for human health and medical
research
• Reasons:
• Understanding of human biology or physiology is based
on domestic animal biology: Chicken embryology
• Several methods developed in animals: IVF/Cloning
• Disease models: Influenza
NIH Participation
• Cattle Genome Project (Baylor College of Medicine), NHGRI
• Horse Genome Project (MIT), NHGRI
• Chicken Genome Project (Washington University), NHGRI
• Although there is no direct involvement with Swine Genome
Project, NIH has always been interested in Swine as a model
for growth, development, and disease since the pattern of
growth and development of pigs is more similar to human.
Several individual projects have been funded by NIH over the
years.
Models for Basic and Applied studies
• Physiology
• Nutrition
• Pregnancy and fetal growth
• Immunology
• Organ transplantation
• Infectious diseases
• *Much less used as genetic models
From Genomes……
What is critically important:
• Functional Annotation of these genomes is
necessary for knowing what is conserved and
what is not
• Genome to phenome correlation
• Easy access of data to the investigators
NIH-USDA Partnership: Research in
Biomedicine and Agriculture Using
Agriculturally Important Domestic Species
(PAR13-204)
Priority Areas
• Assisted Reproduction Technologies/Stem Cell
Biology: Oocyte Biology; Embyro Competence
and Viability; SCNT; iPSC; Transgenesis; Male
Germline Development
• Metabolism: Obesity
• Developmental Origin of Adult Diseases: InUtero Developmental Programming
• Infectious Diseases and Applied Immunology
Projects of Relevance to FAANG
Objectives
• 1. Pablo Ross, University of California, Davis; Epigenetic
Control of Preimplantation Development (R01HD070044)
• 2. R. Michael Roberts, University of Missouri-Columbia;
Induced Pluripotent Stem Cells from Swine: Application to
Genetic Modification (R01HD069979)
• 3. Thomas Spencer, Washington State University, Pullman;
Systems Biology Approach to understand Endometrial
Receptivity and Pregnancy (R01HD072898)
• 4. Randall Prather, University of Missouri, Columbia, MO.
Modification of SCNT donor cell metabolism to mimic
blastomere metabolism (R01HD080636)
• 5. Bhanu Prakash Telugu, University of Maryland, College
Park, MD. Generation of zoonotic influenza resistant
recominant pigs via site-directed technology (USDA)
Questions?
[email protected]
301-435-6889