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Maturation of Erythrocytes
HEMATOPOIESIS
Subdivisions
Lymphopoiesis
stem
Lym
Granulopoiesis
cell
Myelopoiesis
Monocytopoiesis
Erythropoiesis
Megakaryopoiesis
Thrombopoiesis
{
PMN
Eos
Bas
Mon
RBC
Pla

Erythropoiesis:
 is the formation of red blood cells, i.e., the
developmental processes of the red blood cells.
 occurs in the red bone marrow from the
descendants of the proerythroblast stem cell by the
processes of proliferation and differentiation
 each hemocytoblast stem cell can give rise to as
many as 211 mature cells.
 Proerythroblast
is:
 also called a pronormoblast
 the earliest stem cell (derived from the
hemocytoblast = pluripotent
hemopoietic cell)
 found in the red bone marrow which is
committed to develop into a red blood
cell.
The retculocyte is characterized by a
bluish hue due to ribosomes remaining in
its cytoplasm.
Reticulocyte
Red Blood Cell
Polychromotatophilic Normoblasat
Orthochromatophilic Normoblast
and Reticulocyte
 Hemopoietic
Growth Factor is:
 any of the various regulatory proteins and
local hormones which:
▪ target the hematopoietic stem cells in the red
bone marrow
▪ promote the growth, organization, and
maintenance of red bone marrow and blood cells.

Erythropoietin is:
 also referred to as EPO.
 a glycoprotein hormone which stimulates the
production of red blood cells by stem cells in the
red bone marrow.
 produced mainly by the kidneys.
 released in response to decreased levels of oxygen
detected in the blood in the kidney nephron.