Download hhmi resource for new ap bio curriculum

2012
Use Howard Hughes Medical
Institute Resources to Teach:
The New AP® Biology
Course Curriculum
Prepared by:
Ms. Ann Brokaw
AP® Biology Teacher
Rocky River High School
Rocky River, Ohio 44116
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 1 of 54
Use Howard Hughes Medical Institute Resources to Teach:
The New AP® Biology Course Curriculum
Table of Contents:
Page Number
From the Author
2
Introduction to the New AP® ® Biology Course Curriculum
3
How the AP® Biology Teacher Guide Grid Works
3
HHMI BioInteractive Resource Grid
4 - 54
From the Author
With the pace of current research, the Biological Sciences change so incredibly fast, I am keenly aware that I must keep
myself and my students abreast of cutting edge research. Therefore, as a veteran Biology teacher, I am constantly looking
for resources that include up-to-date research, prompt students to process material, help reinforce textbook material,
and stimulate discussions and explorations of current biological topics. For these reasons, I utilize the Howard Hughes
Medical Institute’s (HHMI’s) BioInteractive website and Holiday Lectures on Science DVD’s routinely in my classroom to
highlight and strengthen my day-to-day coverage of material.
Specifically, the BioInteractive and Holiday Lectures on Science resources are accurate, user-friendly, free of charge, and
easily accessible; all of which are key elements of classroom implementation. The video clips, animations, and interactive
“click and learn” activities enhance my formal lecture material to increase student understanding and assist student
visualization of the subject matter. Finally, the Classroom Activities and Virtual Lab series are excellent lessons and
laboratory simulations.
On behalf of my students and myself, I highly recommend the Holiday Lectures on Science DVD’s and the BioInteractive
online resources. These resources have greatly advanced my teaching methods in the classroom, my students’ ability to
understand the material, and our shared knowledge about current findings in Biology.
It is my hope that this curriculum guide will assist in filtering through the vast BioInteractive resources and provide a guide
to all the HHMI resources that correlate with the new AP® Biology course framework developed for implementation in
2012-13. Each part of this curriculum guide organizes HHMI resources that pertain to the new AP® Biology curriculum
specifically the four Big Ideas, the Enduring Understanding’s, and the Essential Knowledge threads contained in the
curriculum. The resources contain animations, lecture material, video clips, interactive “click and learn” activities, virtual
labs and classroom activities specific to the AP® Biology course topics. The resources are logically organized in each table
with the resources grouped together by their subject matter. Please do not hesitate to contact me with any questions or
suggestions you have.
Most sincerely:
Ann Brokaw
AP Biology Teacher
Rocky River High School
Rocky River, Ohio
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 2 of 54
Introduction to the AP® Biology Course Curriculum
The new AP® Biology course curriculum released by the College Board is balancing the overwhelming expansion of the
field of Biology (the breadth) with the depth of understanding of fundamental topics required of the students. The new
course shifts from focusing on content coverage to a focus on enduring conceptual understandings and the supporting
content. For the purpose of this teacher guide, the main foci will be the Big Ideas, Enduring Understandings, and Essential
Knowledge threads of the new curriculum framework. (There are other “divisions” within the College Board’s framework,
but are not included in this guide.) The resource grid on pages 4 through 52 of this guide contains connections to the Big
Ideas, the Enduring Understandings, and the Essential Knowledge sequence. Therefore, if a teacher is looking for a
resource to go with Essential Knowledge 2.C.1.a, the teacher can page through the grid looking for resources linked to
that specific portion of the AP® Biology curriculum. In addition, the College Board has put an extremely strong emphasis
on the seven Science Practices, these practices are referenced throughout the original College Board curriculum
framework document (ex. [See SP 2.2]) illustrating how to effectively integrate them throughout the course.
This teacher guide looks at several different types of resources produced by HHMI’s Department of Science Education.
The types of resources include: animations, video clips, interactive click and learns, lecture clips, classroom activities,
virtual labs, short films and other teacher guides covering various topics. All of the resources are available on
www.BioInteractive.org, and a majority of the resources are also available on the series of DVD’s produced for the Holiday
Lectures on Science each year and the new short films (The Making of the Fittest) also available on DVD. This document
can be downloaded or opened directly from the website. Each resource is hyperlinked; therefore, instructors can click on
the resource title or the thumbprint photo and the resource will open automatically.
How the AP® Biology Teacher Guide Resource Grid Works?
The resource grid on the following pages organizes each resource using the following column headings:
Resource Type:
This column informs the reader as to whether the resource is an animation, video clip, interactive “click and
learn”, lecture clip, classroom activity, virtual lab, short film or another teacher guide covering a specific topic.
Resource Title:
The information in this column includes the exact title of the resource and a thumb-print photo if applicable. The
photos match the resource thumbprints on the website so the resource is more easily located. This column also
includes a hyperlink in each resource (embedded in the title or the photo) so teachers can simply “click and go.”
Resource Summary:
As the name suggests, this column provides a brief summary of the resource and a specific time code where
applicable for the animations, video clips, etc… so it is easy to see how long a video resource will run if used in
the classroom.
AP® Biology Correlations:
This column correlates with the new AP® Biology Curriculum Framework. Each Big Idea (1-4) is at the heading of
a sub-column. As a teacher scans a column under a particular Big Idea, references to enduring understandings
and essential knowledge threads are provided. For example, the reference “4.C.3.c” refers to:
Big Idea 4:
Biological systems interact, and these systems and their interactions
possess complex properties.
Enduring Understanding 4.C:
Naturally occurring diversity among and between components
within biological systems affects interactions with the environment.
Essential Knowledge 4.C.3:
The level of variation in a population affects population dynamics.
Essential Knowledge 4.C.3.Part c: Allelic variation within a population can be modeled by the
Hardy-Weinberg equation(s).
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 3 of 54
HHMI BioInteractive AP® Biology Course Curriculum Resource List and Access Instructions
Holiday Lectures on Science DVD: Bones, Stones, and Genes: The Origin of Modern Humans, 2011
BioInteractive Website Topic: Evolution
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea 1
Big Idea 2
Big Idea 3
Type
1.A.1.a,b
Lecture 1: Human Evolution and
Lecture
Where do we come from? (5:26-8:40)
1.A.4.a,b
the Nature of Science, Ch. 5
1.B.1.a
1.A.1.a,b
Lecture 1: Human Evolution and
Lecture
What is science? (12:27-14:18)
1.A.4.a,b
the Nature of Science, Ch. 7
1.B.1.a
1.A.1.a,b
Lecture 1: Human Evolution and
Lecture
Relationship between medical science and evolution. (14:18-16:03)
1.A.4.a,b
the Nature of Science, Ch. 8
1.B.1.a
1.A.1.a,b
1.A.4.a,b
1.B.1.a
Lecture 1: Human Evolution and
Lecture
Basic classification of great apes and human origins. (18:23-25:00)
1.B.2.a,b,c,d
the Nature of Science, Ch. 10-11
1.C.1.a,b
1.C.2.a,b
1.C.3.a
1.A.4.a,b
1.B.2.a,b,c,d
Lecture 1: Human Evolution and
1.C.1.a,b
Lecture
Phases of human evolution. (27:15-28:29)
the Nature of Science, Ch. 13
1.C.2.a,b
1.C.3.a
Lecture/
Discussion
Genetics of Bitter Taste Perception
Dr. Michael Campbell discusses how humans perceive the taste of the
chemical PTC. With Dr. Sarah Tishkoff, he fields questions about the
evolution of taste perception, and scientific career choices.
(50 min. 38 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 4 of 54
1.A.1.c
1.A.2.a,b,c
1.A.4.a,b
1.C.3.a,b
2.E.1.b
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
Big Idea 4
4.C.1.a,b
4.C.2.a,b
Resource
Type
Animation
Resource Title
Natural Selection of Lactose
Tolerance
AP Biology Correlations
Resource Summary
Big Idea 1
Environmental and cultural factors can affect whether a new human
mutation becomes common in a population. (46 sec.)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 3
The human genome and how we differ from others genetically.
(3:17-4:56)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 4-5
What is our place in the tree of life? (4:57-7:14)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 7
Nuclear DNA and mitochondrial DNA (mtDNA). (8:16-10:24)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 9-11
Using genetic variation to reconstruct lineage history. (11:51-18:01)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 16
Q&A: Why do ape species show more genetic diversity than humans?
(26:25-27:36)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 18
Types of genetic variability in nuclear DNA. (28:28-31:01)
Regulation of the Lactase Gene
Lactase persistence results from a mutation that changes how
transcription factors interact, thereby affecting gene expression.
(21 slides)
Interactive
Click and
Learn
Lactose Digestion in Infants
Animation
The lactase enzyme is produced in the small intestine of infants. It digests
lactose by breaking it into glucose and galactose. (52 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 5 of 54
Big Idea 2
1.A.1.c
1.A.2.a,b,c
1.A.4.a,b
1.C.3.a,b
1.A.1.c
1.A.2.b
1.A.4.b
1.B.1.a
1.A.1.c
1.A.2.b
1.A.4.b
1.B.2.1,b,c,d
1.A.1.c
1.A.2.b
1.A.4.b
1.A.1.c
1.A.2.b
1.A.3.a,b
1.A.4.b
1.B.2.1,b,c,d
1.A.1.c
1.A.2.b
1.A.3.a,b
1.A.4.b
1.A.1.c
1.A.2.b
2.E.1.b
1.A.1.c
1.A.2.a,b,c
2.E.1.b
1.A.1.c
1.A.2.a,b,c
2.E.1.b
Big Idea 3
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
3.A.1.a
Big Idea 4
4.C.2.a,b
3.A.1.a
3.A.1.a
3.A.1.a
3.A.1.a
3.A.1.a
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
4.C.2.a,b
Resource
Type
Animation
Resource Title
Regulation of Eukaryotic DNA
Transcription
AP Biology Correlations
Resource Summary
Big Idea 1
General transcription factors, activators, and repressors interact to
regulate the transcription of eukaryotic DNA into RNA. (2 min. 6 sec.)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 27-28
Lactase persistence as an example of human adaptation. (42:42-46:26)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 30
The genetic basis of lactase persistence in Europe and Africa.
(47:39-50:38)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 31
The genetic footprint of recent natural selection. (50:39-52:55)
Interactive
Click and
Learn
Recent Adaptations In Humans
Lactose tolerance, sickle cell anemia, and bitter taste perception are three
examples of recently evolved human traits. (53 slides)
Lecture
Lecture 2: Genetics of Human
Origins and Adaptations, Ch. 33
Other examples of natural selection in humans. (53:52-55:00)
Using the Scientific Process to
Study Human Evolution
Paleoanthropology provides an excellent example of the scientific process
at work. (24 slides)
Interactive
Click and
Learn
Lecture
Lecture 4: Hominid Paleobiology,
Ch.16
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 6 of 54
Big Idea 3
Big Idea 4
2.E.1.b
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
4.C.2.a,b
1.A.1.c
1.A.2.a,b,c
2.E.1.b
4.C.2.a,b
1.A.1.c
1.A.2.a,b,c
2.E.1.b
1.A.1.c
1.A.2.a,b,c
2.E.1.b
1.A.1.c
1.A.2.a,b,c
1.A.4.a,b
1.C.3.a,b
1.A.1.c
1.A.2.a,b,c
1.A.4.a,b
1.C.3.a,b
1.A.4.a,b
1.B.2.a,b,c,d
1.C.1.a,b
1.C.2.a,b
1.C.3.a
2.E.1.b
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
3.A.3.c
3.B.1.a,b,c,d
3.C.1.a,b,c,d
3.C.2.a
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
Earliest Homo sapiens: Herto (29:10-30:32)
Big Idea 2
1.A.1.c
1.A.2.a,b,c
2.E.1.b
4.C.2.a,b
4.C.2.a,b
4.C.1.a,b
4.C.2.a,b
4.C.1.a,b
4.C.2.a,b
Resource
Type
Resource Title
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture
Lecture 4: Hominid Paleobiology,
Ch.17-18
The delicate process of excavating and cleaning fossils: the Herto skull
(30:33-32:45)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.20-23
Stone tools and human evolution. (33:38-37:50)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.24-26
Australopithecus lineage, 4.2-2 Myr. (37:51-40:39)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.27-28
Neanderthal lineage in Europe, 0.6-0.03Myr (40:40-42:14)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.29-31
Did adaptive radiation occur in human evolution? (42:15-47:10)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.36-37
Ardipithecus and our place in nature. (51:35-53:47)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.38-39
Darwin knew chimpanzees did not evolve into humans. (53:48-56:44)
Skeletons Reveal Human and
Chimpanzee Evolution
Comparing features of a 4.4-million-year-old fossil skeleton to those of
human and chimpanzee skeletons sheds light on our evolutionary history.
(39 slides)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.41-42
Fossils of many types of animals found at Ardi site. (57:51-59:20)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.43-52
Discovery of hominid bones from 4.4 Myr. (Includes the discovery of Ardi)
(59:21-1:13:11)
Interactive
Click and
Learn
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 7 of 54
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.2.a,b,c
1.A.4.a,b
1.B.1.a,b
1.B.2.a,b,c,d
1.C.2.b
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
Big Idea 2
Big Idea 3
Big Idea 4
Resource
Type
Resource Title
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture
Lecture 4: Hominid Paleobiology,
Ch.46
Reconstructing past environment from fossil evidence. (1:02:57-1:06:14)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.47
Early hominid skeletons. (1:06:15-1:07:14)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.48-52
Comparing “Ardi” and “Lucy.” (1:07:15-1:13:11)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.48
Comparing “Ardi” and “Lucy.” (1:07:15-1:07:51)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.52
Comparing feet: “Ardi” and primates. (1:11:56-1:13:11)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.53-54
Making sense of “Ardi’s” characteristics. (1:13:12-1:17:56)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.55-56
Chimpanzee-human common ancestor was not a chimpanzee.
(1:17:56-1:20:56)
Lecture
Lecture 4: Hominid Paleobiology,
Ch.57
Evolution’s perspective: geographic range and preferred habitat.
(1:20:57-1:22:41)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 8 of 54
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
1.A.1.a,b
1.A.4.a,b
1.B.1a,b,c,d
Big Idea 2
Big Idea 3
Big Idea 4
DVD: The Making of the Fittest, 2011
BioInteractive Website Topic: Short Films on Evolution
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Big Idea #4
Type
1.A.1.a,c,d,e
3.C.1.a,b,d
4.B.1.a
Natural Selection & Adaptation
In a complete story, from ecosystem to molecules, pocket mice show us
1.A.2.a,b,c
3.C.2.a
4.C.2.a,b
Film
how random changes in the genome can take many paths to the same
1.A.4.b
4.C.3.a,b
adaptation. (10 min. 25 sec.)
1.C.3.a,b
Classroom
Activity
Allele and phenotype frequencies
in rock pocket mouse population
This activity uses real rock pocket mouse data collected by Dr. Michael
Nachman and his colleagues to illustrate the Hardy-Weinberg principle.
Classroom
Activity
Molecular genetics of color
mutations in rock pocket mice
An activity requiring students to transcribe and translate portions of the
wild-type and mutant rock pocket mouse Mc1r genes and compare
sequences to identify the locations and types of mutations responsible for
the coat color variation described in the film.
Classroom
Activity
Biochemistry and cell signaling
pathway of the Mc1r gene
Advanced activity that requires students to analyze partial DNA sequences
of the Mc1r gene and identify the effects altered amino acid chemistry has
on the functionality of the mutated MC1R protein pathway.
Classroom
Activity
Natural selection and evolution
of rock pocket mouse
populations
Activity in which students analyze amino acid data and draw conclusions
about the evolution of coat color phenotypes in different rock pocket
mouse populations.
The Birth and Death of Genes
For life to survive, it must adapt and readapt to an ever-changing Earth. The
discovery of the Antarctic icefish has provided a stunning example of
adaptation in an environment both hostile and abundant, where the birth
and death of genes have played crucial roles. (13 min. 10 sec.)
The molecular evolution of gene
birth and death
Advanced click-and-learn activity that describes how mutations are an
important part of both the birth and death of genes.
Film
Classroom
Activity
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 9 of 54
1.A.1.a,g,h
1.A.4.b
1.C.3.a,b
4.B.1.a
4.C.3.c
3.A.1.c,d
3.C.1.a,d
3.C.2.a
4.B.1.a
3.D.1.a,b,d
3.D.2.c
3.D.3.a,b
4.A.1.a
4.B.1.a
1.A.1.a,c
1.A.2.b,c
1.C.3.a,b
3.C.1.a,d
4.A.1.a
4.B.1.a
1.A.1.c
1.A.2.a,b,c
1.C.3.a,b
3.C.1.a,b
3.C.2.a
4.B.1.a
3.A.3.c
3.C.1.a,b,c,d
3.C.2.a
4.B.1.a
4.C.1.a,b
1A.1.c
1.A.2.a,b,c
2.E.1.b
Resource
Type
Resource Title
Natural Selection in Humans
Film
Classroom
Activity
Classroom
Activity
Classroom
Activity
Mendelian Genetics, Probability,
Pedigrees, and Chi-Square
Statistics
AP Biology Correlations
Resource Summary
Big Idea 1
In some areas, there is an intimate connection between the infectious
parasitic disease malaria and the genetic disease sickle cell anemia. The
protection against malaria by the sickle-cell mutation shows how evolution
does not necessarily result in the best solution imaginable but proceeds by
whatever means are available. (14 min. 3 sec.)
This classroom activity uses the information presented in the short film The
Making of the Fittest: Natural Selection in Humans to take students through
a series of questions pertaining to the genetics of sickle cell disease and its
relationship to malaria resistance. The questions are divided into sections:
Mendelian Genetics and Probability, Pedigrees, and Chi-Square Statistics.
Population Genetics, Selection,
and Evolution
This hands-on activity, in conjunction with the information presented in the
short film, Making of the Fittest: Natural Selection in Humans, teaches
students about population genetics, the Hardy-Weinberg principle, and the
various modes of natural selection. It uses a simple simulation to guide
students through these concepts.
A Lesson on the Nature of
Science
The activity, when coupled with the film Natural Selection in Humans, asks
students to describe how Dr. Allison’s discovery was made possible through
the work of others. Students are also asked to examine Dr. Allison’s data
and to use this data to support his findings.
Big Idea 2
Big Idea 3
Big Idea 4
1.A.1.a,b,c,e
1.A.2.a,b,c
1.C.3.a,b
3.A.3.c
3.C.1.a,b,d
3.C.2.a
4.B.1.a
4.C.1.a,b
1.A.2.a,b,c
3.A.3.a,b,c
3.A.4.a
3.C.1.a,b,d
3.C.2.a
4.C.1.a,b
1.A.1.a,g,h
1.A.2.a,b,c
1.A.4.b
1.C.3.a,b
3.A.3.a,b,c
3.A.4.a
3.C.1.a,b,d
3.C.2.a
4.B.1.a
4.C.1.b
4.C.3.c
1.A.1.a,b,c,e
1.A.2.a,b,c
1.C.3.a,b
3.A.3.c
3.C.1.a,b,d
4.C.1.a,b
Holiday Lectures on Science DVD: Viral Outbreak: The Science of Emerging Disease, 2010
BioInteractive Website Topic: Infectious Diseases
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1C.3.b
3.C.3.a,b
Dengue Fever Re-Emergence in
the Americas
Since the 1960s dengue fever has spread to many countries and total case
Animation
numbers have exploded. (24 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 10 of 54
Big Idea #4
Resource
Type
Lecture
Resource Title
Lecture 4: Solving SARS and Other
Viral Mysteries, Ch. 4-10
Topics include: PCR, DNA Sequencing, Genetic Engineering, and
Microarrays. The teacher guides were developed to provide topic-specific
organization of BioInteractive resources.
Big Idea 2
Big Idea 3
3.A.1.a,b,e
3.A.1.e
3.A.1.e
PCR is a standard laboratory technique that allows amplification of specific
segments of DNA based on complementarity. (55 sec.)
3.A.1.e
3.C.3.b
Lecture 3: Fighting Viruses in the
Lab and Beyond Ch. 25-26
An RT-PCR test to identify dengue subtypes. (38:38-42:52)
3.A.1.e
3.C.3.b
Lecture 2: The Virus Hunter’s
Toolkit, Ch. 28
Sanger method of DNA Sequencing. (39:49-42:08)
Lecture 2: The Virus Hunter’s
Toolkit, Ch. 23-25
Lecture
DNA Sequence Assembly
3.A.1.e
This “click and learn” activity introduces students to a variety of
sequencing techniques including Sanger, Shotgun, and Deep Sequencing.
It also uses an English language example to guide students through the
assembly of a DNA sequence. (30 slides)
Leading-edge Bioinformatics
Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain
state-of-the-art DNA sequencing and bioinformatic technologies.
(6 min. 35 sec.)
Running a Virochip Experiment
A sample is put on a Virochip microarray, and results are compared to
databases of all known viral sequences. (2 min. 9 sec.)
Video
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 11 of 54
Big Idea 4
3.A.1.e
3.C.3.a,b
DNA hybridization can detect viral DNA in a complex mixture
(34:07-38:30)
Lecture
Animation
SARS: A Global Epidemic (3:52-18:16)
Biotechnology
Animation
Interactive
Click and
Learn
1C.3.b
DNA’s chemical properties can be harnessed for a variety of biotechnology
applications. (2 min. 45 sec.)
The Polymerase Chain Reaction
Lecture
Big Idea 1
The Chemical Structure of DNA
Animation
Teacher
Guide
AP Biology Correlations
Resource Summary
3.A.1.e
3.A.1.e
3.A.1.e
3.C.3.b
4.A.1.a
Resource
Type
Interactive
Click and
Learn
Resource Title
Virochip DNA Microarray
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture 2: The Virus Hunter’s
Toolkit, Ch. 7-8
How do you determine the cause of an infectious disease? (9:37-11:20)
Lecture
Lecture 2: The Virus Hunter’s
Toolkit, Ch. 29-31
PCR, microarrays, and sequencing for viral diagnostics. (42:08-46:56)
Video
Animation
Viral Geometry and Structural
Diversity
Structure of Dengue Virus
Animation
Lecture
Lecture 1: Dengue Fever: Breaking
Epidemic Cycles, Ch. 5
Dengue Virus Life Cycle
Animation
Dengue Virus Enters a Cell
Animation
Lecture
Lecture 1: Dengue Fever: Breaking
Epidemic Cycle, Ch. 13
Big Idea 3
Big Idea 4
3.A.1.e
3.C.3.b
3.A.1.e
Lecture
Bee Colony Collapse Disorder
Big Idea 2
This interactive “click and learn” takes the student through a progression
of slides that introduce the concepts behind the Virochip microarray. The
student is guided through an inquiry portion of the activity in order to run
samples, make predictions, and draw conclusions. (31 slides)
3.A.1.e
3.A.1.e
3.C.3.b
Charles Runckel, a graduate student in the DeRisi lab, uses the Virochip to
examine the mystery of bee colony collapse disorder. (7 min. 45 sec.)
4.B.3.a,c
3.C.3.a,b
The geometric structures of viruses are beautiful and can be used, along
with genomic information, to identify them. (3 min. 22 sec.)
3.C.3.a,b
The dengue virus's outer envelope proteins form symmetrical units and
overlay the lipid envelope, capsid, and the RNA genome. (58 sec.)
3.C.3.a,b
What is dengue fever? (7:28-8:55)
3.C.3.a,b
Dengue virus has sophisticated mechanisms for entering a cell, for
replicating its RNA genome, and for transcribing proteins.
(4 min. 12 sec.)
3.C.3.a,b
Infection begins when the Dengue virus uses receptors on an immune
cell’s surface to gain entry and release its genome. (1 min. 24 sec.)
2.D.4.b
The immune response and severe dengue. (15:11-16:52)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 12 of 54
3.C.3.a,b
3.D.2.a
4.C.1.a
Resource
Type
Resource Title
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture
Lecture 2: The Virus Hunter’s
Toolkit, Ch. 13
Antibodies can recognize specific viruses. (18:36-21:40)
Lecture
Lecture 3: Fighting Viruses in the
Lab and Beyond, Ch. 4
Immune system as potential foe. (4:25-6:29)
Lecture
Lecture 3: Fighting Viruses in the
Lab and Beyond, Ch. 6-8
Antibodies neutralize viruses and tag them for destruction. (8:02-12:55)
Interactive
Click and
Learn
Video
Stopping Mosquito-Borne Disease
Managua: Rapid, Unplanned
Urbanization
The Mosquito Life Cycle
Video
Classroom
Activity
The Mosquito Life Cycle
Learn about the nature of vector-borne diseases, and the life cycle of the
dengue vector mosquito, Interactively explore how to control mosquitoborne diseases. (36 slides) DVD Resource Title: Dengue Vector Intervention
Big Idea 2
Big Idea 3
2.D.4.b
3.C.3.a,b
3.D.2.a
2.D.4.b
3.C.3.a,b
3.D.2.a
2.D.4.b
3.C.3.a,b
3.D.2.a
3.C.3.a,b
Big Idea 4
4.C.1.a
4.B.3.a
4.B.3.a
Poor management of drainage, drinking water, and wastewater, makes
excellent mosquito habitat. (49 sec.)
4.B.3.a
To prevent mosquitoes from spreading diseases, it's essential to
understand their life cycle. (1 min. 16 sec.)
A classroom activity designed to accompany the lecture series Viral
Outbreak: The Science of Emerging Disease.
(Click on hyperlink and scroll down to activity.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 13 of 54
4.B.3.a
Holiday Lectures on Science DVD: Exploring Biodiversity: The Search for New Medicines, 2009
BioInteractive Website Topic: Biodiversity
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1.B.2.a,b,c,d
Biodiversity and Evolutionary Trees This is an activity on biological classification, and it accompanies the
Classroom
lecture series Exploring Biodiversity: The Search for New Medicines.
Activity
Students construct evolutionary trees by sorting seashells.
(Click on hyperlink and scroll down to activity.)
Hidden biodiversity: the microbes. (4:59-8:06)
1.B.1.a
1.B.2.b,c
2.B.3.c
2.D.1.c
Lecture
Three main branches of life. (8:06-10:01)
1.A.4.b
1.B.1.a
1.B.2.b,c
1.D.2.b
2.B.3.c
Lecture 2: Shedding Light on a
Invisible World, Ch. 7-8
Lecture
Lecture 1: From Venoms to Drugs,
Ch. 14
Phylogenetic tree of cone snails. (19:32-21:42)
Lecture
Lecture 1: From Venoms to Drugs,
Ch. 17
Hunting specialization and Phylogenetic tree (22:56-24:20)
Lecture
Lecture 2: Shedding Light on a
Invisible World, Ch. 4-6
Prialt blocks motor synapse in fish
Animation
Prialt blocks pain signaling in Mice
Animation
Lecture
Lecture 1: From Venoms to Drugs,
Ch. 31-33
Big Idea #4
3.A.1.a
4.A.5.a
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
4.A.4.b
4.B.1.a
1.B.2.a,b,c,d
1.B.2.a,b,c,d
Prialt, a drug derived from cone snail venom, paralyzes fish by blocking
calcium channels at a motor synapse. (2 min. 31 sec.)
Prialt does not block the mammalian motor synapse, but blocks the pain
pathway in the spinal cord. (2 min. 58 sec.)
2.B.1.b
2.B.2.a
2.B.1.b
2.B.2.a
Review of synapse function and Prialt action. (46:54-50:54)
Use HHMI resources to teach: The AP® Biology Course Curriculum
2.B.1.b
2.B.2.a
Page 14 of 54
4.A.4.b
4.B.1.a
4.A.4.b
4.B.1.a
Resource
Type
Animation
Animation
Lecture
Interactive
Click and
Learn
Video
Animation
Resource Title
Motor cabal toxins block motor
neuron synapses
Lightning-strike cabal acts like a
Taser
Lecture 2: Shedding Light on a
Invisible World, Ch. 9-16
Bacterial Quorum Sensing
Demonstration: Glowing Bacteria in
a Flask
The Molecular Cascade in Bacterial
Quorum Sensing
Lecture
Lecture 2: Shedding Light on an
Invisible World, Ch. 29
Lecture
Lecture 2: Shedding Light on a
Invisible World, Ch. 32-34
AP Biology Correlations
Resource Summary
Big Idea 1
Multiple cone snail toxins attack different molecules of the nervous
system and cause paralysis. (3 min. 28 sec.)
Some cone snail toxins chemically hyperactivate neurons and immobilize
prey, much like a Taser. (2 min. 9 sec.)
Bacterial cell structure. (10:06-18:31)
This segment of lecture material reviews the prokaryotic cell structure
and the role of bacteria in relation to humans
Understand how quorum sensing works by reasoning through
experiments involving genetically-engineered bioluminescent bacteria.
(13 slides) DVD Resource Title: Quorum Sensing in Vibrio harveyi
Big Idea 2
4.A.4.b
4.B.1.a
2.B.1.b
2.B.2.a
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
4.A.4.b
4.B.1.a
2.B.3.c
3.A.1.a
2.E.2.c
3.D.1.a,c
3.D.2.b
3.D.3.a,b
4.B.2.a
2.E.2.c
3.D.1.a,c
3.D.2.b
3.D.3.a,b
4.B.2.a
2.E.2.c
3.D.1.a,c
3.D.2.b
3.D.3.a,b
4.B.1.a
4.B.2.a
2.E.2.c
3.D.1.a,c
3.D.2.b
3.D.3.a,b
3.B.a.b
3.D.1.a,c
3.D.2.b
3.D.3.a,b
4.B.1.a
4.B.2.a
Quorum sensing regulates gene expression by a protein phosphorylation
cascade that controls transcription. (3 min. 20 sec.)
Quorum sensing and autoinducers. (32:28-34:01)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 15 of 54
Big Idea 4
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio
harveyi. (52 sec.)
Quorum sensing activates a large network of genes. (36:31-40:18)
Big Idea 3
2.B.1.b
2.B.2.a
2.C.1.a
2.E.2.c
4.B.1.a
4.B.2.a
Resource
Type
Animation
Resource Title
Lux Operon Controls Light
Production
AP Biology Correlations
Resource Summary
Big Idea 1
A single transcription factor controls this operon, which contains five
genes necessary to produce bioluminescence. (2 min. 26 sec.)
2.E.2.c
Lecture
Lecture 4: Eavesdropping on Tiny
Conspiracies, Ch. 4-7
Helpful and harmful bacteria use quorum sensing. (4:01-9:26)
Lecture
Lecture 4: Eavesdropping on Tiny
Conspiracies, Ch. 11-15
The Lux signaling cascade in low cell density. (12:41-21:01) This portion of
material discusses the specifics of the molecular cascade involved in
quorum sensing and the role of RNA interference during the process.
Lecture
Lecture 4: Eavesdropping on Tiny
Conspiracies, Ch. 17-19
Two parallel QS (quorum sensing) circuits. (22:40-25:32) These 3 chapters
discuss the differences between a bacterium communicating with “self”
and “non-self” and the role of gene expression in those processes.
Lecture
Lecture 3: Biodiversity at a Snail’s
Pace, Ch. 6-7
Venom components disable different targets and block a different
synaptic event. (6:26-8:37)
A Taser Causes Rigid Paralysis
Video
Conus bullatus “Lightning Strike”
Video
Video
Lecture
Bobtail squid swimming and
burrowing
Lecture 2: Shedding Light on an
Invisible World, Ch. 17-21
Big Idea 2
2.C.1.a
2.E.2.c
A Taser hyper-excites the nervous system to cause a rigid immobilization
of its target. (30 sec.)
This species of cone snail immobilizes its prey in a split second with
lightning-strike cabal toxins. (1 min. 11 sec.)
2.C.1.a
2.E.2.c
2.C.1.a
2.E.2.c
2.B.1.b
2.B.2.a
2.B.1.b
2.B.2.a
2.B.1.b
2.B.2.a
Big Idea 3
3.B.a.b
3.D.1.a,c
3.D.2.b
3.D.3.a,b
3.D.1.a,c
3.D.2.b
3.D.3.a,b
3.B.a.b
3.D.1.a,c
3.D.2.b
3.D.3.a,b
3.B.a.b
3.D.1.a,c
3.D.2.b
3.D.3.a,b
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
Big Idea 4
4.B.1.a
4.B.2.a
4.B.2.a
4.B.1.a
4.B.2.a
4.B.2.a
4.A.4.b
4.A.4.b
4.A.4.b
4.A.6.e
4.B.3.a
4.B.3.a
The bobtail squid swims during the night to hunt. During the day, it
burrows to hide from predators. (1 min. 3 sec.)
A model system to study host-bacterial interactions. (18:31-25:36)
This segment of lecture illustrates the relationship between the bobtail
squid and bioluminescent bacteria.
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 16 of 54
4.B.3.a
Resource
Type
Resource Title
Demonstration: A live Cone Snail
Video
Philippines Biodiversity
Video
Conus catus strikes a fish
Video
Conus striatus strikes a fish
Video
Conus textile strikes a snail
Video
Conus imperialis strikes a worm
Video
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
Big Idea 3
4.B.3.a
Dr. Olivera demonstrates a live specimen of Conus striatus.
(1 min. 3 sec.)
4.B.3.a
The Philippines archipelago is rich in marine biodiversity, including
venomous octopus and venomous snails. (2 min. 8 sec.)
A fish-hunting cone snail strikes its prey with a venomous harpoon,
causes paralysis, and eats it. (2 min. 11 sec.)
A species of fish-hunting cone snail quickly immobilizes its prey and
swallows it. (45 sec.)
A snail-hunting species of cone snail stings its prey repeatedly, inducing
the prey to thrash about. (43 sec.)
A worm-hunting cone snail species feeds on fireworms, and is unaffected
by the prey's sharp bristles. (31 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 4
Page 17 of 54
2.B.1.b
2.B.2.a
2.B.1.b
2.B.2.a
2.B.1.b
2.B.2.a
2.B.1.b
2.B.2.a
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2.a,b,c,d
4.A.4.b
4.B.3.a
4.A.4.b
4.B.3.a
4.A.4.b
4.B.3.a
4.A.4.b
4.B.3.a
Holiday Lectures on Science DVD: Making Your Mind: Molecules, Motion, and Memory, 2008
BioInteractive Website Topic: Neuroscience
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Big Idea #4
Type
2.B.1.b
3.D.2.b
4.A.4.b
Molecular mechanism of synaptic
2.B.2.a
3.D.3.a,b
function
Electrical and chemical signals are used by neurons to communicate with
Animation
3.D.4.a
one another at contact points called synapses. (1 min. 9 sec.)
3.E.2a,b,c,d
Interactive
Click and
Learn
Animation
Animation
Electrical Activity of Neurons
Signal Molecules Trigger
Transcription Factors
Development of the Human
Embryonic Brain
Measuring neuronal activity, generating action potentials, and recording
the firing of individual neurons. (13 slides)
2.B.1.b
2.B.2.a
2.E.1.a,b
3.D.2.b
3.D.3.a,b
3.D.4.a
3.E.2a,b,c,d
3.B.1.a,b,c,d
4.A.4.b
4.A.3.a,b
Varying concentrations of a signaling molecule activate different
transcription factors and determine cell fate. (2 min. 4 sec.)
2.E.1.a,b
4.A.3.a,b
2.E.1.a,b
4.A.3.a,b
The fetal brain grows enormously during pregnancy, both in terms of its
size and the number of neurons it has. (1 min. 40 sec.)
Lecture
Lecture 2: Building Brains: The
Molecular Logic of Neural Circuits,
Ch 10-14
How do neurons differentiate during development? (13:06-22:55)
This portion of lecture material reviews human development and then
discusses specific genes controlling brain development. This segment
includes two animations to help students visualize the process.
Lecture
Lecture 2: Building Brains: The
Molecular Logic of Neural Circuits,
Ch. 15-20
Studying simple motor circuits in the spinal cord. (22:55-31:38)
This portion of the lecture teaches the role of the Sonic Hedgehog protein
and its role as a signaling molecule during embryonic development.
Lecture
Lecture 4: Memories Are Made of
This, Ch. 31-36
Aging, memory loss, and Alzheimer disease. (42:37-52:07)
Use HHMI resources to teach: The AP® Biology Course Curriculum
2.E.1.a,b
3.D.4.a
3.E.2.a,b,c,d
Page 18 of 54
Resource
Type
Animation
Animation
Animation
Animation
Resource Title
Molecular Activity in Aplysia
Long Term-Memory
Molecular Activity in Aplysia
Short Term-Memory
Molecular basis of early LTP
(short-term memory)
Molecular basis of late LTP
(long-term memory)
AP Biology Correlations
Resource Summary
Big Idea 1
Long-term memory requires the activation of CREB, turning on specific
genes that support new synaptic growth. (1 min. 39 sec.)
Short-term memory relies on serotonin activating a protein kinase to
modify existing synaptic strength. (2 min. 30 sec.)
Early LTP (short-term memory) depends on a calcium-dependent protein
kinase to strengthen an existing synapse. (1 min. 28 sec.)
Late LTP (long-term memory) involves dopamine activation of CREB to
support new synaptic growth. (56 sec.)
Lecture
Lecture 2: Building Brains: The
Molecular Logic of Neural Channels.
Ch. 6-9
Comparing the brain to a cell phone and zooming in on circuits and single
neurons. (7:37-13:06)
Lecture
Lecture 1: Mapping Memory in the
Brain, Ch. 8-9
Gall’s insights into the brain. (11:17-13:04)
Lecture
Lecture 1: Mapping Memory in the
Brain, Ch. 12-14
Broca challenges Gall’s theory by studying brain function. (17:16-21:26)
Lecture
Lecture 1: Mapping Memory in the
Brain, Ch. 15-17
Wernicke: Complex brain functions are not in a single area. (21:26-26:28)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 19 of 54
Big Idea 2
Big Idea 3
Big Idea 4
3.D.2.b
3.E.2.a,b,c,d
4.A.3.b
3.D.2.b
3.D.3.b
3.D.4.a
3.E.2.a,b,c,d
4.A.3.b
3.D.2.b
3.D.3.b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.b
3.D.4.a
3.E.2.a,b,c,d
3.D.2.b
3.D.3.b
3.D.4.a
3.E.2.a,b,c,d
3.E.2.d
4.A.3.b
3.E.2.d
3.E.2.d
4.A.3.b
Holiday Lectures on Science DVD: AIDS: Evolution of an Epidemic, 2007
BioInteractive Website Topic: Infectious Diseases
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
2.D.3.a
3.C.3.a,b
This guide includes a classroom-ready worksheet to accompany the HHMI
Immunology
2.D.4.a,b
3.D.1.a,d
Teacher
immunology virtual lab, as well as immunology unit daily lesson plans
2.E.1.c
3.D.2.a
Guide
based on a wide range of strategies for teaching immunological concepts
3.D.3.a,b
in the classroom.
3.D.4.a
2.D.3.a
3.C.3.a,b
Interactive Cells of the Immune System
This mini-lesson covers the basics of the human immunological response
2.D.4.a,b
3.D.1.a,d
Click and
and includes embedded lecture video clips. (11 slides)
2.E.1.c
3.D.2.a
Learn
DVD Resource Title: Immunology Primer
3.D.3.a,b
3.D.4.a
2.D.3.a
3.C.3.a,b
Antigen Presentation and CTL
Animation shows how a cell that is infected by a virus triggers cytotoxic T
2.D.4.a,b
3.D.1.a,d
Animation
cells to kill the viral infected cell prior to the virus replication and
2.E.1.c
3.D.2.a
spreading. (2 min. 34 sec.)
3.D.3.a,b
3.D.4.a
2.D.3.a
3.C.3.a,b
CTL Killing a Target Cell
2.D.4.a,b
3.D.1.a,d
This video clip shows actual video microscopy of a cytotoxic T lymphocyte
Video Clip
2.E.1.c
3.D.2.a
in action. (1 min. 16 sec.)
3.D.3.a,b
3.D.4.a
2.D.3.a
3.C.3.a,b
2.D.4.a,b
3.D.1.a,d
Lecture 1: From Outbreak to
Lecture
Cells of the Immune System. (19:13-19:54)
2.E.1.c
3.D.2.a
Epidemic, Ch. 14
3.D.3.a,b
3.D.4.a
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 20 of 54
Big Idea #4
4.C.1.a
4.C.1.a
4.C.1.a
4.C.1.a
4.C.1.a
Resource
Type
Lecture
Lecture
Lecture
Lecture
Lecture
Resource Title
Lecture 1: From Outbreak to
Epidemic, Ch. 15
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 17
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 24
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 27
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 31
Demo: Rapid AIDS Virus Test
Video Clip
AP Biology Correlations
Resource Summary
Big Idea 1
Antigen-presenting cells and helper T cells. (19:54-20:45)
Helper T cells orchestrate the immune response. (22:32-24:03)
Humoral immunity and antigen binding. (33:06-34:03)
Mechanism of Cytotoxic T lymphocytes (CTL’s). (37:16-38:51)
How helper T cells orchestrate an immune response. (44:34-45:07)
This video clip demonstrates a live introduction to an antibody-based
ELISA for detecting HIV. (7 min. 40 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 21 of 54
Big Idea 2
Big Idea 3
Big Idea 4
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
4.C.1.a
Resource
Type
Lecture
Lecture
Resource Title
Lecture 1: From Outbreak to
Epidemic, Ch. 29-31
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 10-12
The Immunology Lab
Virtual Lab
Lecture
Interactive
Click and
Learn
Lecture 1: From Outbreak to
Epidemic, Ch. 28
Retroviruses and Viral Diversity
HIV Life Cycle
Animation
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
Antibodies to HIV found in infected people. (40:28-43:02)
2.D.3.a
2.D.4.a,b
2.E.1.c
Development of an antibody response. (12:24-16:53)
2.D.3.a
2.D.4.a,b
2.E.1.c
This virtual laboratory will demonstrate how such a test, termed an
enzyme-linked immunosorbent assay (ELISA), is carried out and some of
the key experimental problems that may be encountered.
HIV: The retrovirus that causes AIDS. (39:28-40:27)
A brief discussion of what makes a virus a retrovirus, and how they differ
from other types of viruses. (7 slides)
How HIV infects a cell and replicates itself using reverse transcriptase and
the host's cellular machinery. (4 min. 52 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 22 of 54
Big Idea 3
Big Idea 4
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
4.C.1.a
4.C.1.a
Resource
Type
Resource Title
U.S. Aids Epidemic
Animation
HIV’s Origins in Africa
Video
Lecture
Lecture
Lecture
Lecture
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 23
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 25
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 32
Lecture 2: AIDS and the HIV Life
Cycle, Ch. 33
AP Biology Correlations
Resource Summary
Big Idea 1
A visual representation of the U.S. AIDS epidemic from 1981 to 1997. Each
dot represents 30 cases. (31 sec.)
Dr. Beatrice Hahn discusses how HIV originated in Africa by cross-species
transmission from chimpanzees to humans. (1 min. 12 sec.)
Is the immune system trying to keep HIV in check? (31:52-33:06)
Antibodies neutralize HIV by binding to its surface proteins. (34:03-35:19)
By eliminating helper T cells, HIV disables the immune response.
(45:07-47:23)
Summary: Conclusions of HIV and the Immune Response. (47:23-49:22)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 23 of 54
Big Idea 2
Big Idea 3
Big Idea 4
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
4.C.1.a
Resource
Type
Resource Title
AZT Blocks Reverse Transcriptase
Animation
Lecture
Lecture
Lecture 3: Drugs and HIV
Evolution, Ch. 6
Lecture 3: Drugs and HIV
Evolution, Ch. 7
Protease Inhibitors
Animation
Lecture
Lecture
Lecture 3: Drugs and HIV
Evolution, Ch. 4
Lecture 3: Drugs and HIV
Evolution, Ch. 18
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
Big Idea 3
Big Idea 4
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.B.1.a
4.C.1.a
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
AZT: The first antiretroviral used to fight HIV. (7:43-8:49)
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.B.1.a
4.C.1.a
AZT’s mechanism of action. (8:49-9:33)
2.D.3.a
2.D.4.a,b
2.E.1.c
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.B.1.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.C.1.a
2.D.3.a
2.D.4.a,b
2.E.1.c
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
4.B.1.a
4.C.1.a
HIV's reverse transcriptase mistakes AZT for thymidine. Once
incorporated, AZT stops reverse transcription. (1 min. 46 sec.)
Protease inhibitors prevent maturation of viral proteins inside HIV
particles. (1 min. 6 sec.)
Antiretroviral therapy can halt progression to AIDS. (4:23-5:52)
People who have mutant CCR5 coreceptors avoid infection.
(19:01-20:31)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 24 of 54
Resource
Type
Lecture
Lecture
Resource Title
Lecture 4: Vaccines and HIV
Evolution, Ch. 13-15
Lecture 4: Vaccines and HIV
Evolution, Ch. 6-10
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
2.D.3.a
2.D.4.a,b
2.E.1.c
HIV mutation leads to staggering diversity in HIV genome
(14:37-18:48)
2.D.3.a
2.D.4.a,b
2.E.1.c
How vaccines are developed and how they work. (5:52-12:02)
Big Idea 3
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
3.C.3.a,b
3.D.1.a,d
3.D.2.a
3.D.3.a,b
3.D.4.a
Big Idea 4
4.B.1.a
4.C.1.a
4.C.1.a
Holiday Lectures on Science DVD: Potent Biology: Stem Cells, Cloning, and Regeneration, 2006
BioInteractive Website Topic: Stem Cells
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
Cytoplasmic factors play a significant part in determining how a cell
2.E.1.a,b
3.B.1.a,b,c,d
Cytoplasmic Factors
Animation
develops. This segment discusses their importance in turning the
appropriate genes on and off for proper development. (56 sec.)
Human embryonic development depends on stem cells. During
2.E.1.a,b
3.A.2.a,b
Human Embryonic Development
Animation
development, cells divide, migrate, and specialize. Early in development, a
group of cells called the inner cell mass (ICM) forms. (2 min. 18 sec.)
Lecture 1: Understanding
2.E.1.a,b
3.A.2.a,b
Lecture
Development is growth and differentiation. (7:04-15:02)
Embryonic Stem Cells, Ch. 5-9
2.E.1.a,b
3.B.1.a,b,c,d
Lecture 1: Understanding
Progressive development creates specialized cells. (18:33-23:43) These 3
Lecture
Embryonic Stem Cells, Ch. 13-15
chapters discuss how genes are turned on and off as cells differentiate.
2.E.1.a,b
3.B.1.a,b,c,d
Lecture 1: Understanding
Cytoplasmic factors affect cell fate. (24:22-27:34) The 2 chapters here
Lecture
Embryonic Stem Cells, Ch. 17-18
illustrate how cell-to-cell interaction affects the cell fate.
2.E.1.a,b
3.A.2.a,b
Differentiation and the Fate of
As a human embryo develops, its cells become progressively restricted in
3.B.1.a,b,c,d
Cells
Animation
the types of specialized cells that they can produce. Inner cell mass cells of
the blastocyst can make any type of body cell. (1 min. 28 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 25 of 54
Big Idea #4
4.A.3.a,b
4.A.3.a,b
4.A.3.a,b
4.A.3.a,b
4.A.3.a,b
4.A.3.a,b
Resource
Type
Animation
Video
Lecture
Lecture
Interactive
Click and
Learn
Resource Title
Creating Embryonic Stem Cell
Lines
Cultured Human Embryonic Stem
Cells
Lecture 1: Understanding
Embryonic Stem Cells, Ch. 25-30
Lecture 1: Understanding
Embryonic Stem Cells, Ch. 35-40
Big Idea 1
The inner cell mass (ICM) cells of blastocyst-stage early human embryos
can be removed and cultured. These cells can be grown in the lab
indefinitely. (1 min. 37 sec.)
Cell cultures derived from human embryonic stem cells can reproduce
indefinitely and also differentiate into specialized cell types, including
beating heart cells. (1 min. 17 sec.)
Body maintenance and renewal. (33:26-40:44)
Embryonic stem cells and their traits. (46:56-54:51)
Big Idea 2
Big Idea 3
Big Idea 4
2.E.1.a,b
4.A.3.a,b
2.E.1.a,b
4.A.3.a,b
2.E.1.a,b
3.A.2.a,b
4.A.3.a,b
2.E.1.a,b
3.A.2.a,b
4.A.3.a,b
Tissue Regeneration in Animals
An overview and comparison of different regenerative capabilities in many
different organisms. (19 slides)
DVD Resource Title: Regeneration - Evolution and Medicine
2.E.1.a,b
4.A.3.a,b
Zebrafish Heart Regeneration
The zebrafish heart is similar to the human heart in many respects. But
unlike the human heart, the fish heart closes wounds rapidly and then
regenerates to nearly full function. (2 min. 29 sec.)
2.E.1.a,b
4.A.3.a,b
2.E.1.a,b
4.A.3.a,b
2.E.1.a,b
4.A.3.a,b
Animation
Lecture
AP Biology Correlations
Resource Summary
Lecture 4: Stem Cells and the End
of Aging, Ch. 30-41
Newt Limb Regeneration
Animation
Potential cell therapy for heart failure. (37:28-54:45)
Urodele amphibians—newts and salamanders—are able to regenerate
fully functional limbs in response to amputation. (1 min. 20 sec.)
Lecture
Lecture 2: Adult Stem Cells and
Regeneration, Ch. 4-9
Overview of cell differentiation, replenishment, and renewal.
(4:45-10:37)
Lecture
Lecture 2: Adult Stem Cells and
Regeneration, Ch. 10
Stem cells are rare in adults. (10:37-12:20)
Lecture
Lecture 2: Adult Stem Cells and
Regeneration, Ch. 11-14
Some animals can regenerate body parts. (12:20-15:54)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 26 of 54
2.E.1.a,b
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
4.A.3.a,b
Resource
Type
Video
Classroom
Activity
Lecture
Lecture
Interactive
Click and
Learn
Classroom
Activity
Lecture
Lecture
Lecture
Lecture
Lecture
Resource Title
Planarian Regeneration and Stem
Cells
Planarian Regeneration Activity
Lecture 2: Adult Stem Cells and
Regeneration, Ch. 25-27
Lecture 2: Adult Stem Cells and
Regeneration, Ch. 30-32
Stem Cell-Based Therapies
Stem Cells and Diabetes
Lecture 3: Coaxing Embryonic
Stem Cells, Ch. 22-26
Lecture 3: Coaxing Embryonic
Stem Cells, Ch. 29-34
Lecture 3: Coaxing Embryonic
Stem Cells, Ch. 27-28
Lecture 4: Stem Cells and the End
of Aging, Ch. 4-13
Lecture 2: Adult Stem Cells and
Regeneration, Ch. 35-38
Somatic Cell Nuclear Transfer
Video
AP Biology Correlations
Resource Summary
Big Idea 1
A mini-documentary discussing the remarkable regenerative capabilities
of the planarian, and how researchers use them to study the biology of
stem cells. (11 min. 46 sec.)
This is a classroom laboratory activity that accompanies the lecture series
Potent Biology: Stem Cells, Cloning, and Regeneration.
(Click on hyperlink and scroll down to activity.)
Problems with mammalian regeneration. (28:58-32:11)
Identifying the signals that control limb re-growth. (34:58-38:55)
An exploration of current and future therapies. (13 slides)
DVD Resource Title: Stem Cell Therapy
This activity has three distinct parts and a review game that may be done
together or at different points in the year to learn about stem cell
research focused on a possible treatment for diabetes.
(Click on hyperlink and scroll down to activity.)
Pancreatic β cells and type I diabetes. (28:32-35:18)
Big Idea 2
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
2.E.1.a,b
3.A.2.a,b
3.D.4.a
2.E.1.a,b
2.E.1.a,b
3.A.2.a,b
3.D.4.a
3.A.2.a,b
3.D.4.a
3.E.2.a,b,c
2.E.1.a,b
3.D.4.a
2.E.1.a,b
3.A.1.e
3.A.2.a,b
3.D.4.a
3.A.1.e
2.E.1.a,b
Challenges in studying degenerative diseases. (37:41-46:52)
Deriving motor neurons from stem cells. (35:18-37:41)
Physiological characteristics of aging. (4:21-16:09)
Muscular Dystrophy overwhelms stem cell capacity. (42:41-49:30)
This portion of the lecture material provides an example of how transgenic
mice are used in current human disease research.
Somatic cell nuclear transfer (SCNT) is performed looking through a
microscope and using small glass pipettes to handle human eggs and to
remove and transfer nuclei from one cell to another. (1 min. 59 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 27 of 54
Big Idea 3
2.E.1.a,b
Big Idea 4
4.A.4.b
Resource
Type
Lecture
Resource Title
Lecture 3: Coaxing Embryonic
Stem Cells, Ch. 4-12
DNA Gene Chip Explanation
Video
Lecture
Lecture 1: Understanding
Embryonic Stem Cells, Ch. 14-15
AP Biology Correlations
Resource Summary
Big Idea 1
Stem cells and cloning (4:28-19:34) This 15 minute clip explains the use of
somatic cell nuclear transfer in stem cell research today.
Big Idea 2
2.E.1.a,b
Big Idea 4
3.A.1.e
3.B.1.a,b,c,d
Dr. Melton describes the process used to extract DNA from a cell and to
analyze it on a gene chip. (1 min. 40 sec.)
Demo: Using a DNA chip to study gene expression (19:57-23:42)
Includes a discussion regarding genes being turned on and off at each step
of differentiation.
Big Idea 3
3.A.1.e
2.E.1.a,b
3.A.1.e
3.B.1.a,b,c,d
4.B.3.a,b
Special DVD: Fossils, Genes, and Mousetraps, 2006
BioInteractive Website Topic: Evolution
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Big Idea #4
Type
1.A.1.a,c,d,e,f
1.A.2.a,b
Lecture
Fossils, Genes, and Mousetraps,
Is Evolution a theory? (6:04-20:42)
1.A.3.a,b
Ch. 3-9
1.A.4.a,b
1.C.3.a
1.A.1.a,c,d,e,f
Fossils, Genes, and Mousetraps,
1.A.2.a,b
Lecture
Fossils and Evolution. (20:42-26:46)
Ch. 10-12
1.A.3.a,b
1.A.4.a,b
1.A.1.a,c,d,e,f
3.A.1.a,b
4.A.1.a,b
1.A.2.a,b
Fossils, Genes, and Mousetraps,
Molecular evolution: chimps and humans
Lecture
1.A.3.a,b
Ch. 13
(26:46-32:37)
1.A.4.a,b
1.B.1.a,b
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 28 of 54
Holiday Lectures on Science DVD: Evolution: Constant Change and Common Threads, 2005.
BioInteractive Website Topic: Evolution
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1.A.1.a,c,d,e,f
Interactive Natural and Artificial Selection
Learn about artificial and natural selection. Features multiple clips from
1.A.2.d
Click and
the lectures on evolution. (6 slides) DVD Resource Title: Selection
Learn
1.A.1.a,c,d,e,f
Lecture 3: Fossils, Genes, and
Lecture
Laws of nature lead to natural selection. (4:53-26:17)
1.A.2.a,b,c
Embryos, Ch. 4-17
1.C.3.a,b
1.A.1.a,c,d,e
3.C.1.a,b,d
Pocket Mouse and Predation
The rock pocket mouse is found in two color variants, or morphs: light
1.A.2.a,b,c
3.C.2.a
Animation
and dark. The dark morph is more vulnerable to predators on light sandy
1.A.4.b
desert, and the light morph on dark lava rock. (20 sec.)
1.C.3.a,b
1.A.1.a,c,d,e
3.C.1.a,b,d
Pocket Mouse Evolution
This simulation shows the spread of a favorable mutation through a
1.A.2.a,b,c
3.C.2.a
Animation
population of pocket mice. Even a small selective advantage can lead to
1.A.4.b
a rapid evolution of the population. (1 min. 4 sec.)
1.C.3.a,b
1.A.1.a,c,d,e
3.C.1.a,b,d
Evolution in action: The rock pocket mouse. (44:35-50:49)
Lecture 1: Endless Forms Most
1.A.2.a,b,c
3.C.2.a
Lecture
This segment of material shows how mutation rate is associated with
Beautiful, Ch. 28-34
1.A.4.b
selection and evolution.
1.C.3.a,b
1.A.1.a
Lecture 1: Endless Forms Most
Lecture
Charles Darwin. (6:51-28:44)
Beautiful, Ch. 4-16
1.A.1.a
Lecture 1: Endless Forms Most
Lecture
Darwin’s first big idea: Descent with modification. (31:08-41:35)
Beautiful, Ch. 19-25
Lecture 1: Endless Forms Most
1.A.1.a
Lecture
Darwin’s second big idea: Natural selection. (41:35-44:35)
Beautiful, Ch.26-27
Fossil Record of Stickleback
1.A.1.a,c,d,e,f
A quarry site in Nevada carries the evolutionary history of a population
Evolution
1.A.2.a,b,c
Animation
of stickleback fish that resided there when it was a freshwater lake.
1.A.4.b
(1 min. 26 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 29 of 54
Big Idea #4
4.B.1.a
4.C.2.a,b
4.C.3.a,b
4.C.2.a,b
4.C.3.a,b
4.B.1.a
4.C.2.a,b
4.C.3.a,b
Resource
Type
Resource Title
Stickleback Environment
Video
Lecture
Classroom
Activity
Classroom
Activity
Lecture 2: Selection in Action
Ch. 27-36
Adaptive radiation from the ancestral form in sticklebacks. (35:04-44:08)
Survival of the Fittest – Variations in
the Clam Species Clamys sweetus
Survival of the Fittest: Variations in the Clam Species Clamys sweetus is a
guided inquiry. This activity has been designed to engage students in
thinking about the mechanism of natural selection by encouraging them
to formulate questions that can be answered through scientific
investigation, data collection, and pattern recognition.
Breeding Corn from Teosinte
Video
Lecture 2: Selection in Action
Ch. 4-8
Dog Breeding
Video
Animation
At the end of the ice age, the retreating ice sheet created many new
lakes, some of which were colonized by sticklebacks. The presence of
different predators in different lakes dictated the subsequent evolution
of each isolated lake stickleback. (1 min. 26 sec.)
Survival of the Fittest—Battling Beetles is a guided inquiry. The overall
goal of Battling Beetles is to engage students in thinking about the
mechanism of natural selection through data collection and pattern
recognition. (Click on hyperlink and scroll down to activity.)
Animation
Lecture
Big Idea 1
Survival of the Fittest – Battling
Beetles
Pitx 1 Expression
Lecture
AP Biology Correlations
Resource Summary
Lecture 2: Selection in Action
Ch. 13-18
Paintbrush Gene
In the stickleback fish, pelvic-fin reduction resulted from changes in the
regulatory switch elements of the Pitx1 gene. (54 sec.)
Corn was originally bred from the teosinte plant by native Mexican
farmers. The morphologies of modern-day corn and teosinte plants are
compared to illustrate how artificial selection can bring about dramatic
changes in plants. (52 sec.)
Natural selection and artificial selection. (5:03-10:44)
The many forms of dogs that exist today were all created through
selective (artificial) breeding from the dog's ancestor, the wolf.
(1 min. 52 sec.)
Dogs and selective breeding. (16:24-25:01)
In two related Drosophila species, a so-called paintbrush gene is
activated to "paint" the pigment on the body. In one species, an extra
switch activates the gene, resulting in spotted wings. (49 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 2
Big Idea 3
Big Idea 4
1.A.1.a,c,d,e,f
1.A.2.a,b,c
1.A.4.b
1.A.1.a,c,d,e,f
1.A.2.a,b,c
1.A.4.b
1.A.1.a,c,d,e,f
1.A.1.a,c,d,e,f
1.A.1.a,c,d,e,f
1.A.2.a,b,c
1.A.4.b
3.B.1.a,b,c,d
3.C.1.d
1.A.1.a,c,d,e,f
1.A.2.d
1.A.1.a,c,d,e,f
1.A.2.d
1.A.1.a,c,d,e,f
1.A.2.d
1.A.1.a,c,d,e,f
1.A.2.d
1.A.1.a
Page 30 of 54
3.B.1.a,b,c,d
3.C.1.d
4.B.1.a
Resource
Type
Resource Title
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture
Lecture 4: From Butterflies to
Humans, Ch. 4-8
Darwin’s theory helped in understanding new discoveries. (5:04-11:10)
Lecture
Lecture 4: From Butterflies to
Humans, Ch. 9-13
Data from butterflies offers insight into our own evolution.
(11:10-16:01)
Lecture
Lecture 4: From Butterflies to
Humans, Ch. 14-18
Spots evolved via new use of old toolkit gene. (16:01-21:23)
These chapters include material on toolkit gene expression as related to
wing spots.
Lecture
Lecture 4: From Butterflies to
Human, Ch. 19-22
Genes are reused in different ways via genetic switches. (21:23-25:41)
These 4 chapters discuss the significance of genetic switches and the role
of evolution in the gain and loss of control.
Lecture
Lecture 4: From Butterflies to
Humans, Ch. 24-31
T. H. Huxley in 1863 on human evolution and fossil evolution in humans.
(27:05-35:55)
Lecture
Lecture 4: From Butterflies to
Humans, Ch. 32-33
Hominid skull evolution. (35:55-38:32)
Lecture
Lecture 4: From Butterflies to
Humans, Ch. 34-36
Traits that distinguish humans from other apes. (38:32-42:35)
Lecture
Lecture 3: Fossils, Genes, and
Embryos, Ch. 26-27
Lecture
Lecture 4. From Butterflies to
Humans, Ch. 35-37
Lecture
Lecture 2: Selection in Action,
Ch. 9-12
Interactive
Click and
Learn
Visualizing Gene Expression
Patterns
Organisms share molecular pathways and enzymes. (34:55-36:06).
In addition, this portion of material explains that organisms also share
DNA as a basis for heredity.
What can we learn about human evolution? (40:10-45:07) These 3
chapters illustrate how we use DNA to study human evolution and our
relatedness to chimps.
Mendelian inheritance pattern: A one-gene trait. (10:44-16:24)
This segment of lecture uses corn to illustrate the importance of a single
gene to an organism
1.A.1.c
1.A.2.b
1.A.4.b
1.A.1.c
1.A.2.b
1.A.4.b
1.A.1.c
1.A.2.b
1.A.4.b
1.B.1.a
1.A.1.a
1.A.4.b
1.A.1.a
1.A.4.b
1.B.2.b,c
1.A.1.a
1.A.4.b
1.B.2.b,c
1.B.2.b,c
1.B.1.a
1.B.2.b,c
Learn about the different ways scientists are able to detect when genes
are being expressed in various tissues. (19 slides)
DVD Resource Title: Visualizing Gene Expression
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 2
1.A.1.a
Page 31 of 54
Big Idea 3
Big Idea 4
3.E.1.a,c
2.E.1.a,b
3.E.1.a,c
2.E.1.a,b
3.B.1.a,b,c,d
3.C.1.d
2.E.1.a,b
3.B.1.a,b,c,d
3.C.1.d
3.A.1.a
3.A.1.d
3.A.3.a,b
3.A.4.a,b
3.A.1.e
3.B.1.a,b,c,d
3.B.2.a,b
3.C.1.d
4.A.1.a
Resource
Type
Resource Title
Wing Morph
Animation
Interactive
Click and
Learn
Genetic Switches
Gene Switch
Animation
Classroom
Activity
Lecture
Gene Switches
Lecture 3: Fossils, Genes, and
Embryos, Ch. 32-39
Fruit Fly Courtship
Video
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
3.A.1.e
3.B.1.a,b,c,d
3.B.2.a,b
3.C.1.d
3.A.1.e
3.B.1.a,b,c,d
3.B.2.a,b
3.C.1.d
3.A.1.e
3.B.1.a,b,c,d
3.B.2.a,b
3.C.1.d
3.A.1.e
3.B.1.a,b,c,d
3.B.2.a,b
3.C.1.d
This "morph" animation demonstrates how the expression of a
particular toolkit gene in a butterfly larva corresponds to the location of
the wing eyespots in an adult butterfly. (28 sec.)
Learn about how gene switches can control expression of genes in
different tissues. (2 slides) DVD Resource Title: Gene Switches
Regulatory "switches" are found upstream from a gene. Regulatory
molecules recruit RNA polymerase to bind to the gene's promoter
region, increasing the transcription of the gene into messenger RNA.
(1 min. 14 sec.)
Conceptually, how genetic switches function and their role in the
process of evolution, can be difficult for students to visualize. This
activity can be done as a demonstration, a student activity, or a
combination of the two. (Click on hyperlink and scroll down to activity.)
Pax6 is a toolkit gene that turns other genes on and off. (41:23-48:39)
This lecture portion covers material pertaining to the Pax6 and Pitx
genes and how they function during gene expression.
Male courtship dances in two fruit fly species show that the wing spots
play a prominent role. (55 sec.)
Big Idea 3
2.E.1.a,b
3.B.1.a,b,c,d
3.B.2.a,b
3.C.1.d
3.E.1.a,b,c
Big Idea 4
4.A.3.a,b
4.A.3.a,b
4.A.3.a,b
4.A.3.a,b
Holiday Lectures on Science DVD: The Science of Fat, 2004.
BioInteractive Website Topic: Obesity
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Big Idea #4
Type
Mouse Activity
1.A.1.c
3.C.1.a,b,d
4.B.1.a
Dr. Evans compares the activity of a normal mouse to one with a mutation
1.A.2.b
3.C.2.a
Video
in a key gene controlling obesity. (29 sec.)
3.D.1.d
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 32 of 54
Resource
Type
Resource Title
Marathon Mice
Video
Interactive
Click and
Learn
Molecular Structure of Fat
Interactive
Click and
Learn
How the Body Uses Fat
Lecture
Lecture 1: Deconstructing
Obesity, Ch. 18-26
Location of the Hypothalamus
Animation
Lecture
Lecture 4: Exploring Obesity:
From the depths of the brain to
the far Pacific, Ch. 6-12
The Fate of Fat
Animation
Animation
Lecture
PPAR-gamma Activation in the
Fat Cell
Lecture 3: Balancing the Fat
Equation, Ch. 6-10
AP Biology Correlations
Resource Summary
Big Idea 1
Dr. Ronald Evans discusses the so-called "marathon" mouse, with a
mutation in the PPAR-gamma gene, and its performance on a treadmill
relative to a normal mouse. (52 sec.)
This slide show delves into the various molecular shapes that fat can take.
(18 slides)
This slide show explores some of the ways the body processes fat, including
digestion, transport, conversion, and energy extraction. (27 slides)
Adoption and twin studies show that obesity is highly heritable. (33:3152:37)
Big Idea 2
1.A.1.c
1.A.2.b
2.A.1.a,d
2.A.3.a
4.A.1.a
3.E.2.d
3.D.2.b
3.E.2.a,b,c
How does leptin act on a neuron? (7:38-20:22)
The PPAR-gamma receptor activates certain genes in a fat cell, resulting in
the storage of fat and changes in hormone levels. (2 min. 48 sec.)
Two types of hormone action: at the membrane and at the nucleus.
(8:36-18:48) This 10 minute segment includes information regarding how
endocrine hormone signals get received and the role of nuclear based
receptors in gene expression regulation.
Page 33 of 54
4.B.1.a
4.A.1.a
1.A.1.c
1.A.2.a,b
1.A.4.b
2.A.1.a
2.A.3.a
An overview of how dietary fat gets digested, packaged, and sent to various
tissues for storage or energy. (2 min. 7 sec.)
Big Idea 4
2.A.3.a
A 3-D animation that shows the location of the hypothalamus in a mouse's
brain. (33 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 3
3.C.1.a,b,d
3.C.2.a
3.D.1.d
1.A.1.c
1.A.2.b
3.B.1.a
3.C.1.a,b,d
3.C.2.a
3.D.1.d
2.C.1.a
3.B.1.a
3.D.1.a.d
3.D.2.c
3.D.3.a
3.D.4.a
Resource
Type
Animation
Resource Title
PPAR-delta Activation in the
Muscle Cell
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
2.C.1.a
The PPAR-delta receptor activates certain genes in a muscle cell, resulting
in the burning of fat. (1 min. 44 sec.)
2.C.1.a
Lecture
Lecture 3: Balancing the Fat
Equation, Ch. 19-24
Pima Indians
Video
Lecture
Lecture 4: Exploring Obesity:
From the depths of the brain to
the far Pacific, Ch. 20-27
Can we use PPAR-delta to increase metabolism? (33:32-45:46)
A clip about the Pima Indian tribe and how environment has affected them.
(2 min. 35 sec.)
How does variation in genes lead to obesity? (31:14-47:47) This illustrates a
genetic variation study using an isolated population on a Pacific island. It
traces inheritance of SNP’s and using DNA chips to analyze the data.
Big Idea 3
Big Idea 4
3.B.1.a
3.D.1.a.d
3.D.2.c
3.D.3.a
3.D.4.a
3.B.1.a
3.D.1.a.d
3.D.2.c
3.D.3.a
3.D.4.a
1.A.1.c
1.A.2.a,b
1.A.4.b
1.B.1.a
1.B.2.c
1.A.1.c
1.A.2.a,b
1.A.4.b
1.B.1.a
1.B.2.c
Holiday Lectures on Science DVD: Learning from Patients: The Science of Medicine, 2003.
BioInteractive Website Topics: Cancer (Lectures 1 and 2) and Neuroscience (Lectures 3 and 4)
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Big Idea #4
Type
3.A.2.b
4.B.1.a
SCA1 Pedigree
Illustrates how studying one family's pedigree can reveal an entire history
3.A.3.a,b,c
Animation
of passing on a genetic disorder such as SCA1. (30 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 34 of 54
Resource
Type
Classroom
Activity
Video
Resource Title
Pedigree Analysis Activity
Learning from Mice: The Science of
Transgenic Technology
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture 2: Chaos to Cure: Bringing
Basic Research to Patients, Ch. 8
Using genetically engineered mice to find treatments for FAP.
(14:07-16:23)
Lecture
Lecture 4: The Strength of Families:
Solving Rett Syndrome, Ch. 31-34
Designing a mouse model for Rett Syndrome. (41:08-48:51) This segment
of the lecture demonstrates the use of transgenic organisms in addressing
human diseases such as Rett Syndrome.
2.E.1.e
3.A.1.a,c,d,e
3.C.1.a
3.A.4.b
3.B.1.c
3.D.1.d
Lecture 4: The Strength of Families:
Solving Rett Syndrome, Ch. 11-14
Four family pedigrees shed light on the pattern of inheritance.
(12:45-18:11)
3.A.1.a,c,d,e
3.C.1.a
3.C.3.a,b,c
Rett Syndrome
Dr. Zoghbi introduces the topic of Rett syndrome by showing how
development usually progresses in a young girl. (2 min. 51 sec.)
Rett Syndrome Mouse
Dr. Zoghbi shows how a mouse that has been given the gene responsible
for Rett syndrome exhibits some of the same neurological symptoms as
human Rett patients. (1 min. 13 sec.)
Video
The Proteasome and Protein
Regulation
The Proteasome
Animation
3.A.1.a,e
This animation shows how the random deactivation of one of the X
chromosomes in a pair can lead to a mozaicism in the expression of
genes. (55 sec.)
Video
The Proteasome is a large molecular machine that plays an important
role in recycling and regulating cellular proteins. (5 slides)
DVD Resource Title: Structure of the Proteasome
A 3D animation showing how proteins in the cell are tagged for disposal
and degraded by the proteasome. (1 min. 43 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 35 of 54
Big Idea 4
3.A.1.a,e
3.A.2.b
3.A.3.a,b,c
X-inactivation
Animation
Interactive
Click and
Learn
Big Idea 3
3.A.2.b
3.A.3.a,b,c
What do humans, flies, and worms have in common? More than you
might think. See how transgenic organisms are engineered, and how they
enable researchers to study genetic diseases. (11 min. 7 sec.)
Lecture
Lecture
Big Idea 2
A classroom activity to accompany the lecture series Learning from
Patients: The Science of Medicine. (Click on hyperlink and scroll down to
activity.)
2.E.1.e
3.A.1.a,c,d
3.B.1.c,d
3.C.1.a
2.E.1.e
3.A.1.a,e
3.B.1.c,d
4.B.1.a
3.A.1.c
3.B.1.c
4.A.1.a
3.A.1.c
3.B.1.c
4.A.1.a
Resource
Type
Lecture
Resource Title
Lecture 3: A Healthy Nervous
System: A Delicate Balance,
Ch. 30-31
MECP2
Animation
Lecture
Interactive
Click and
Learn
Lecture 4: The Strength of Families:
Solving Rett Syndrome, Ch. 25-27
Print
Article
Print
Article
Big Idea 1
Protein accumulation occurs in many neurodegenerative diseases.
(44:21-48:46)
This animation shows how the protein MECP2, in conjunction with
another protein complex, can act as an "on-off' switch for gene
expression. (43 sec.)
What does methyl-CpG (MECP2) binding protein do? (27:46-32:14)
This portion of the lecture discusses how MECP2 regulates gene
expression.
The p53 Gene and Cancer
One very important molecule relating to cancer is called p53. Learn about
what p53 does, and how interfering with its function can lead to cancer.
(8 slides) DVD Resource Title: p53: Guardian of the Genome
p53
A 3D animation showing the molecule p53 binds to DNA and initiates the
transcription of mRNA. (25 sec.)
Animation
Lecture
AP Biology Correlations
Resource Summary
Lecture 1: Research Mechanics:
Putting the Brakes on Cancer,
Ch. 28-31
Evolution of Cancer
Understanding Cancer Diversity
p53 gene is mutated in most cancers. (45:56-52:04)
Cancers grow and spread by a process akin to evolution. A cancer cell
accumulates mutations, each of which can give the cell a growth
advantage over its neighbors. This single cell will divide to populate the
tumor until another cell with an even better growth advantage crops up.
At that point, the more aggressive cell reproduces rapidly, taking over the
tumor. It’s survival of the fittest, with every cell for itself.
The human body operates, in essence, like a large, multicellular society.
Within this tight-knit community, trillions of cells, organized into
hundreds of different tissues, collaborate for the good of the whole
organism. Some cells convert food into energy, some transport oxygen or
nutrients throughout the body, some fight infections, and some shuttle
the organism's genes into the next generation.
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 36 of 54
Big Idea 2
Big Idea 3
3.A.1.c
3.B.1.c
3.D.4.a
3.A.1.c
3.B.1.c,b,d
3.D.1.d
3.D.3.b
3.A.1.c
3.B.1.c,b,d
3.D.1.d
3.D.3.b
3.A.2.a
3.B.2.b
Big Idea 4
4.A.1.a
4.A.1.a
4.A.1.a
3.A.2.a
3.B.2.b
3.A.2.a
3.B.2.b
3.C.1.a,b
3.C.2.a
3.A.2.a
3.B.2.b
3.D.4.a
3.A.2.a
3.B.2.b
3.D.4.a
4.B.1.a
Resource
Type
Resource Title
Using p53 to Fight Cancer
Animation
VEGF
Animation
Trinucleotide Repeat
Animation
AP Biology Correlations
Resource Summary
Big Idea 1
This animation demonstrates how cancerous cells could be destroyed
using a modified virus. (1 min. 1 sec.)
VEGF (Vascular Endothelial Growth Factor) is a signaling molecule that
binds to receptors on blood vessels. The binding VEGF to the receptors
signals the blood vessels to sprout and elongate. Tumors release VEGF
thus supporting their further growth. (29 sec.)
Slippage during DNA replication can lead to expanding sections of
repeating nucleotides. Watch this animation to see how this problem
occurs. (1 min. 7 sec.)
Lecture
Lecture 3: A Healthy Nervous
System: Delicate Balance, Ch. 11-13
CAG Trinucleotide Repeat Expansion Causes SCA1 (19:41-23:56)
This segment discusses the role of the number of repeats as it relates to
age of disease onset.
Lecture
Lecture 3: A Healthy Nervous
System: A Delicate Balance, Ch. 14
CAG Repeat produces polyglutamine, causing many diseases.
(23:56-26:16)
Lecture
Lecture 3: A Healthy Nervous
System: A Delicate Balance,
Ch. 21-22
Is SCA1 caused by a loss-of-function mutation? Or, is SCA1 caused by a
gain-of-function mutation? (33:31-36:46)
Lecture
Lecture 1: Research Mechanics:
Putting the Brakes on Cancer,
Ch. 6-8
Lecture
Lecture 1: Research Mechanics:
Putting the Brakes on Cancer,
Ch. 9-12
Lecture
Lecture 1: Research Mechanics:
Putting the Brakes on Cancer, Ch.13
Big Idea 3
3.A.2.a
3.B.2.b
3.C.1.a,b
3.C.3.b
3.A.2.a
3.B.2.b
3.D.1.d
3.D.3.a,b
3.D.4.a
3.C.1.a,b,c
3.C.2.a
3.A.1.c
3.C.1.a,b,c
3.C.2.a
3.A.1.c
3.C.1.a,b,c
3.C.2.a
3.A.1.c
3.C.1.a,b,c
3.C.2.a
3.A.2.a
3.B.2.b
3.D.4.a
Nature of cancer: malignancy and metastasis. (11:17-16:05)
3.A.2.a
3.B.2.b
3.D.4.a
Many types of cancer. (16:05-21:44)
3.A.2.a
3.B.2.b
3.D.4.a
Review of tumor definition. (21:44-22:47)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 2
Page 37 of 54
Big Idea 4
4.B.1.a
4.B.1.a
4.B.1.a
4.B.1.a
Resource
Type
Lecture
Lecture
Resource Title
Big Idea 1
Lecture 1: Research Mechanics:
Putting the Brakes on Cancer,
Ch. 18-25
Theories on What Causes Cancer. (27:07-43:08)
This 16 minute clip clearly illustrates the role of mutations in cancer, why
DNA replication is not perfect, and an example of a human cancer.
Lecture 2: Chaos to Cure: Basic
Research to Patients, Ch. 22-26
Cancer Cells Have Altered Chromosomes. (32:43-38:54)
This lecture material discusses chromosomal translocations with a look at
leukemia and Gleevec as a treatment option.
CML and Gleevec
Animation
Gleevec
Animation
Lecture
AP Biology Correlations
Resource Summary
Lecture 3: A Healthy Nervous
System: A Delicate Balance,Ch. 4-6
Big Idea 2
Chronic myeloid leukemia (CML) is caused by a mutation that leads to an
abnormal protein that is always active. The drug Gleevec has a shape that
fits into the active site of the abnormal protein and stops its harmful
effects. (41 sec.)
Ideally cancer treatments target specific weaknesses in the cell processes
that lead to cancer. The drug Gleevec has been designed to disrupt the
growth of leukemia cells by blocking a binding site of a key protein found
only in tumor cells. (1 min. 3 sec.)
The importance of balance and coordination in everyday life. (5:27-11:01)
Big Idea 3
Big Idea 4
3.A.2.a
3.B.2.b
3.C.1.a,b,c
3.C.2.a
3.A.2.a
3.B.2.b
3.C.1.a,b,c
3.C.2.a
3.D.4.a
3.C.1.a,b,c
3.C.2.a
3.D.4.a
4.B.1.a
3.D.4.a
4.B.1.a,b
4.B.1.a
4.B.1.a,b
3.D.1.d
3.E.2.a,b,c
Holiday Lectures on Science DVD: Scanning Life’s Matrix: Genes, Proteins, and Small Molecules, 2002.
BioInteractive Website Topic: Genomics and Chemical Genetics
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
Interview with Dr. Eric Lander
1.A.4.b
3.A.1.e
An interview with Dr. Eric Lander, a leading genomics researcher.
Video
(5 min. 30 sec.) This is one of the original scientists involved in the Human
Genome Project.
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 38 of 54
Big Idea #4
Resource
Type
Interactive
Click and
Learn
Resource Title
Using DNA to Trace Human
Migration
Lecture
Lecture 1: Reading Genes and
Genomes, Ch. 4-6
Lecture
Lecture 1: Reading Genes and
Genomes, Ch. 7-10
Lecture
Lecture 1: Reading Genes and
Genomes, Ch. 11-15
Lecture
Lecture 1: Reading Genes and
Genomes, Ch. 22-24
Lecture
Lecture 1: Reading Genes and
Genomes, Ch. 24-28
Lecture
Lecture 1: Reading Genes and
Genomes, Ch. 29-31
Lecture
Lecture 3: Human Genomics: New
Guide for Medicine, Ch. 4-6
Lecture
Lecture 3: Human Genomics: New
Guide for Medicine, Ch. 7-8
AP Biology Correlations
Resource Summary
Big Idea 1
All living humans originated from populations of ancestors who migrated
out of Africa less than 100,000 years ago. Learn how genetic markers have
been used to trace the migration routes. (19 slides)
DVD Resource Title: Origins of Modern Humans
Geneticists are interested in human variation. (6:18-11:46)
Big Idea 2
3.A.1.a
1.A.4.b
1.B.1.a,b
3.A.1.a
th
Classroom
Activity
Animation
Review of genetic advances in the 20 century. (11:46-18:46)
This portion of the lecture reviews the history of genetic discovery and
relates genetic advances to research of human disease.
Genetic basis of cystic fibrosis and the Human Genome Project.
(18:46-25:04) This portion of the lecture reviews the history of the human
genome project and the various historical methods of DNA sequencing.
How big is the human genome? (33:08-41:00) These chapters include
information regarding the size of the human genome, an example to
demonstrate the size, and how genes are found within the genome.
Finding Genes in the Genome. (38:43-45:55) This lecture segment presents
information regarding the genes in the human genome: the number, the
location, and the homology between other vertebrates.
Human and mouse comparisons: The mouse as a model for humans.
(45:55-50:03)
Observing what nature has already perturbed. (5:38-10:04) Included here
is a discussion regarding the similarity of DNA between two people.
Human origins and why we have little genetic variation. (10:04-13:49)
This portion of lecture traces human migration by looking at genetic
variation.
3.A.1.e
3.A.1.a
4.A.1.a,b
1.A.4.b
1.B.1.a,b
3.A.1.a,b,c
4.C.1.b
1.A.4.b
1.B.1.a
1.B.1.a
3.A.1.a
1.A.4.b
1.B.1.a,b
3.A.1.a
This classroom activity is designed to accompany the lecture series
Scanning Life's Matrix: Genes, Proteins, and Small Molecules. It involves
students building a variety of biochemically important molecules.
(Click on hyperlink and scroll down to activity.)
2.A.3.a
Small-Molecule Microarrays
To screen many small molecules at once, microarray technology is useful.
Automated devices have made it possible for thousands of different small
molecules to be printed as an array of spots on a glass slide. (59 sec.)
2.A.3.a
Page 39 of 54
Big Idea 4
3.A.1.e
Molecular Menagerie –
A Modeling Activity
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 3
1.A.4.b
1.B.1.a,b
4.A.1.a,b
3.A.1.e
Resource
Type
Lecture
Resource Title
Lecture 4: Chemical Genomics:
New Tools for Medicine, Ch. 12-15
Gene Chip Manufacturing
Animation
Interactive
Click and
Learn
Lecture
Lecture
Interactive
Click and
Learn
Finding new small-molecule probes with a small molecule microarray.
(17:17-22:46) This segment of lecture material reviews small molecule
microarrays, limitations of this type of microarray, and an animation.
Dr. Eric Lander describes the process used to manufacture gene chips.
Gene chips have a broad range of applications in current research,
including enabling researchers to measure the activity of thousands of
genes simultaneously. (1 min. 56 sec.)
DNA microarrays are an important new technology for genomic research.
Learn how researchers use computing to analyze and interpret the huge
datasets generated by microarray experiments. (26 slides)
DVD Resource Title: Analyzing Microarray Data
Lecture 3: Human Genomics: A
New Guide for Medicine,
Ch. 22-24
Lecture 3: Human Genomics: A
New Guide for Medicine,
Ch. 25-28
Microarray Manufacturing
Technology
The discovery of two kinds of leukemia. (35:47-41:17)
These 3 chapters explain how microarrays are made and how they are
used in current human disease research.
Using microarrays to detect the activities of all the genes in a tumor.
(41:17-49:14) This portion of the lecture material pertains to leukemia
specific research and the role of microarrays in that research.
Microarrayer in Action
Lecture 2: Probing Genes and
Genomes, Ch. 4-8
Myosin II Mechanism
Animation
Lecture
Big Idea 1
How to Analyze DNA Microarray
Data
Video
Lecture
AP Biology Correlations
Resource Summary
Lecture 2: Probing Genes and
Genomes, Ch. 15-17
Big Idea 2
2.A.3.a
Big Idea 3
Big Idea 4
3.A.1.e
3.A.1.e
4.A.1.a,b
3.A.1.e
4.A.1.a,b
3.A.1.e
4.A.1.a,b
3.A.1.e
3.A.1.e
How both gene chips and microarray slides are created. (2 slides)
DVD Resource Title: Making a Microarray
How a microarraying robot delivers hundreds of small molecules to a
series of slides. (1 min. 59 sec.)
If you want to understand life’s processes, perturb them. (4:49-11:40)
This lecture segment illustrates research methods to study proteins,
genetics, and gene regulation.
Myosin II is one of the molecules involved in furrow formation in dividing
cells. This animation shows how the molecule operates, and how
furrowstatin blocks the mechanism and halts division of a cell. (57 sec.)
3.A.1.c
3.B.1.a,c,d
3.A.2.a,b
3.A.2.a,b
Using the arrested furrow to study cell division. (19:14-23:54)
Use HHMI resources to teach: The AP® Biology Course Curriculum
3.A.1.e
Page 40 of 54
4.A.1.a,b
Resource
Type
Resource Title
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture
Lecture 3: Human Genomics: New
Guide for Medicine, Ch. 9-12
What differences do genetic variations make? (13:49-20:47)
These 4 chapters discuss the role of SNP’s in various human diseases.
Lecture
Lecture 3: Human Genomics: New
Guide for Medicine, Ch. 14-16
Filling in life’s matrix: Genes, phenotypes, and SNP’s. (22:44-29:03)
This section includes examples of genetic bases of human phenotype
variation.
Interactive
Click and
Learn
Small Molecule Diversity
Big Idea 2
Big Idea 3
Big Idea 4
3.A.1.a
3.B.1.d
3.C.1.a,b
3.C.2.a
3.A.1.a
3.B.1.d
3.C.1.a,b
3.C.2.a
1.A.4.b
1.B.1.a,b
Small molecules are chemicals that can interact with proteins to affect
their functions. Learn about various small molecules like sugar and
caffeine. (22 slides) DVD Resource Title: Molecular Menagerie
4.B.1.a,b,c
Holiday Lectures on Science DVD: The Meaning of Sex: Genes and Gender, 2001.
BioInteractive Website Topic: Sex Determination
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big
Idea
#1
Big Idea #2
Big Idea #3
Type
Lecture 3: Sex and Death: Too
3.A.2.a,b
Lecture
Review of mitotic chromosome segregation. (32:55-37:59)
Much of a Good Thing
3.A.3.b
How
did
the
human
Y
chromosome
become
so
small
relative
to
its
X
1.A.4.b
3.A.4.b
Evolution of the Y Chromosome
counterpart? This animation depicts the 300-million-year odyssey of the
3.B.2.a
Animation
sex chromosomes that began when the proto X and Y were an identical
pair. (5 min. 38 sec.)
2.E.1.c
Lecture 2: Hermaphrodites: The
Lecture
Introduction to the nematode Caenorhabditis elegans. (8:08-17:22)
Safer Sex, Ch 5-11
Lecture
Lecture 2: Hermaphrodites: The
Safer Sex, Ch 12-17
Lecture
Lecture 2: Hermaphrodites: The
Safer Sex, Ch 25-27
Life cycle of a hermaphrodite. (17:22-23:37) This 6 minute section uses C.
elegans as a model organism to study embryonic development, gene
expression, and the activation of sex-determining genes.
The basis of sex-determination in C. elegans. (28:44-32:13)
This segment of lecture explains the role of the sex-determining gene and
how there is a balance of signal elements and protein activity.
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 41 of 54
2.E.1.a,b,c
3.A.1.c
3.B.2.a
2.E.1.a,b,c
3.A.1.c
3.B.2.a
Big Idea #4
Resource
Type
Resource Title
Meiosis
Animation
Lecture
Lecture 1: Deciphering the
Language of Sex, Ch. 26
The Y Chromosome
Animation
Lecture
Lecture 4: Sexual Evolution: From
X to Y, Ch. 7-10
Lecture
Lecture 1: Deciphering the
Language of Sex, Ch. 13-15
Lecture
Lecture 2: Hermaphrodites: The
Safer Sex, Ch 32-35
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
Meiosis, the form of cell division unique to egg and sperm production, sets
the stage for sex determination by creating sperm that carry either an X or
a Y sex chromosome. (5 min. 52 sec.)
1.A.4.b
3.A.4.b
3.B.2.a
3.A.4.b
3.B.2.a
3.A.4.b
3.B.2.a
3.A.1.c
2.E.1.a,b,c
MIX-1
Animation
Big Idea 4
3.A.2.c
Meiosis is the defining feature of sexual reproduction. (36:52-38:21)
The Y chromosome has been likened to a hall of mirrors because its
sequence contains many sections that appear to be palindromes, which
provide a clue to some interesting events that may have occurred during
the course of its evolution. (2 min. 45 sec.)
What does the Y chromosome do? (12:14-19:27) This lecture segment
includes a map of the Y chromosome and information about the classes of
genes found on the Y chromosome.
Discovery of how sex chromosomes operate in humans. (20:13-25:39)
This portion of lecture material discusses the genes associated with sex
determination and specifically the SRY gene in males.
Review of the central dogma of genetics. (38:17-44:40) This segment
begins with a review of basic gene expression and concludes with a
summary of the repression mechanisms of xol-1 during RNA splicing.
Big Idea 3
3.A.2.c
This animation shows how MIX-1 facilitates both chromosome
condensation and dosage compensation. (3 min. 38 sec.)
3.A.1.a,d
3.A.2.a,b
3.A.3.b
3.B.1.c,d
3.B.2.a
3.D.2.b
Holiday Lectures on Science DVD: Clockwork Genes: Discoveries in Biological Time, 2000.
BioInteractive Website Topic: Biological Clocks
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1.B.1.a,b
Lecture 2: Unwinding Clock
Similarity of cellular structures and genomes between humans and
Lecture
Genetics, Ch. 8
Drosophila (11:40-13:39)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 42 of 54
Big Idea #4
Resource
Type
Animation
Animation
Resource Title
The Drosophila Molecular Clock
Model
The Mammalian Molecular Clock
Model
Mouse Circadian Activity
Video
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
Big Idea 3
3.B.1.c
Watch these animations display the dynamic orchestration of the
molecular events of the Drosophila biological clock. (7 min. 34 sec.)
2.B.3.b
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
2.B.3.b
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
3.B.1.c
This animation shows the molecular interactions involved in the negative
feedback loop responsible for circadian rhythms in mammals.
(3 min. 40 sec.)
This time-lapse video clip illustrates a mouse's nocturnal behavior.
(41 sec.)
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
Lecture
Lecture 2: Unwinding Clock
Genetics, Ch. 25-29
Beginning the molecular era: Cloning of the period gene. (34:29-42:50)
This segment includes a detailed discussion of the period gene; its location,
organization, and role.
Lecture
Lecture 3: PERfect TIMing,
Ch. 4-6
Summary of the fruit fly’s circadian clock. (6:11-11:31) This segment of
lecture includes information regarding genes associated with biological
clocks.
Lecture
Lecture 3: PERfect TIMing,
Ch. 8-13
Currently known Drosophila clock genes. (12:24-22:06) These chapters
explain the main genes associated with circadian rhythm in fruit flies – the
PER and TIM genes.
Lecture
Lecture 4: The Mammalian
Timekeeper, Ch. 21-23
Nine different proteins related to circadian clock genes. (30:50-35:10)
This portion of material discusses the clock genes and related proteins
associated with these genes, and it includes an animation.
Lecture
Lecture 4: The Mammalian
Timekeeper, Ch. 5-9
Genetic Approaches in mice: the model mammalian system. (7:25-16:34)
These 5 chapters present an example of how transgenic mice are used to
screen and analyze genes for mutants.
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 43 of 54
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
2.E.2.b
2.E.3.b
Big Idea 4
3.A.1.c
3.A.1.c
4.A.1.a
3.A.1.c
4.A.1.a
Resource
Type
Lecture
Virtual
Lab
Lecture
Resource Title
Lecture 4: The Mammalian
Timekeeper, Ch. 11-14
The Transgenic Fly Virtual Lab
Lecture 2: Unwinding Clock
Genetics, Ch. 9-11
AP Biology Correlations
Resource Summary
Big Idea 1
Big Idea 2
Positional-cloning analysis to map the Clock gene. (17:26-24:07) This
lecture portion discusses positional-cloning as a technique to use in
conjunction with transgenic mice to map genes.
This lab will familiarize you with the science and techniques used to make
transgenic flies. In this lab, you will create a transgenic fly to study
circadian rhythms. The fly glows only when a certain gene involved in
circadian rhythms is activated.
Big Idea 3
Big Idea 4
3.A.1.c,e
3.A.1.c,e
2.B.3.b
2.C.1.a
2.C.2.a
2.E.2.b
2.E.3.b
Behavior in fruit flies. (13:39-17:31)
3.A.1.c,e
4.A.1.a
Holiday Lectures on Science DVD: 2000 and Beyond: Confronting the Microbe Menace, 1999.
BioInteractive Website Topic: Infectious Diseases
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1.A.2.c,d
3.A.1.a
Bacterial Conjugation
Bacteria can transfer genetic material, and thus drug resistance, to other
1.C.3.b
3.C.1.d
Animation
bacteria via conjugation. (23 sec.)
3.C.2.b
Recombination of Viral Genome
Animation
Bacterial Growth
Video
Listeria Infection
Video
When two different strains of influenza infect a single cell, their genetic
material can mix freely, resulting in a new strain of influenza.
(3 min. 5 sec.)
1.C.3.b
This microscope video shows how living Listeria move via actin filaments
in an infected cell. (1 min. 7 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 44 of 54
3.C.3.a,b
2.C.2.a
2.D.1.a,b,c
Dr. Brett Finlay shows how bacteria can grow rapidly to incredible
numbers, and also explains what limits this explosive growth. (54 sec.)
1.C.3.b
Big Idea #4
2.D.1.b
3.C.2.b
4.B.3.a
Resource
Type
Lecture
Virtual
Lab
Lecture
Lecture
Resource Title
Lecture 1: Microbe Hunters:
Tracking Infectious Agents, Ch. 4-5
The Bacterial Identification Virtual
Lab
Lecture 1: Microbe Hunters:
Tracking Infectious Agents, Ch. 9
Lecture 2: The Microbes Strike
Back, Ch. 16-19
E. coli Infection Strategy
Animation
1.C.3.b
The purpose of the lab is to familiarize you with the science and
techniques used to identify different types of bacteria based on their DNA
sequence.
Watch this animation to see the molecular tricks that an infectious strain
of Escherichia coli uses to infect your gut. (2 min. 52 sec.)
Lecture
Lecture 3: Outwitting Bacteria’s
Wily Ways, Ch. 13-19
E. coli’s Type III secretion system explained. (17:10-25:56)
Interactive
Click and
Learn
Lecture
Lecture 3: Outwitting Bacteria’s
Wily Ways, Ch. 24-31
Antibiotics Attack!
Lecture 2: The Microbes Strike
Back, Ch. 20-25
2.B.3.c
2.A.3.b
2.B.1.a,b
2.D.3.a
1.C.3.b
2.B.3.c
1.C.3.b
2.A.3.b
2.B.1.a,b
2.D.3.a
2.A.3.b
2.B.1.a,b
2.B.2.b,c
2.B.3.b
2.D.3.a
2.A.3.b
2.B.1.a,b
2.B.2.b,c
2.B.3.b
2.D.3.a
Page 45 of 54
4.B.3.a
3.D.1.a
3.D.3.b
4.A.2.e,f
4.B.3.a
3.D.1.a
3.D.3.b
4.A.2.e,f
4.B.3.a
1.C.3.b
3.C.1.d
4.B.3.a
1.C.3.b
3.C.1.d
4.B.3.a
Introduction to and discussion of Salmonella. (32:04-40:19)
How do we fight bacteria? (24:15-28:29)
4.A.1.a
4.B.3.a
4.A.1.a
4.B.3.a
1.C.3.b
Five major sections with animations cover bacteria, antibiotic structure,
pathways of attack, penicillin, and antibiotic resistance.
3.D.1.a
3.D.3.b
3.D.1.a
3.D.3.b
In this animation, you can see how one S. typhimurium invades an
epithelial cell of the intestinal tract, survives the intracellular defense
mechanisms of the host cell, and multiplies. (1 min. 18 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 4
3.A.1.a,e
1.C.3.b
1.C.3.b
Lecture
Big Idea 3
1.C.3.b
Bacteria cause many diseases. (18:10-24:15)
Introduction to and discussion of E. coli.(10:32-17:10)
Big Idea 2
2.D.1.b
1.A.4.b
1.B.1.a
1.C.3.b
Classes of Microbes. (13:23-13:43)
Lecture 3: Outwitting Bacteria’s
Wily Ways, Ch. 6-12
Animation
Big Idea 1
Bubonic plague. (7:41-9:33)
Lecture
Intracellular Infection by
Salmonella
AP Biology Correlations
Resource Summary
Resource
Type
Resource Title
Penicillin Acting on Bacteria
Video
Lecture
Lecture 2: The Microbes Strike
Back, Ch. 27-31
Viral Lifecycle
Animation
Animation
Lecture 1: Microbe Hunters:
Tracking Infectious Agents, Ch. 10
Lecture 1: Microbe Hunters:
Tracking Infectious Agents,
Ch. 11-13
Life Cycle of Malaria
Part 1: Human Host
Animation
Life Cycle of Malaria
Part 2: Mosquito Host
Lecture
Lecture
AP Biology Correlations
Resource Summary
Big Idea 1
Penicillin, as shown in this video, causes the cell walls of bacteria to
rupture. (33 sec.)
Bacteria can develop antibiotic resistance. (29:20-35:18)
Delivering a single virus to a cell allows the virus to infect the cell,
replicate, and give rise to many progeny viruses. These viruses can then
infect many neighboring cells. (1 min. 8 sec.)
What are viruses? (13:43-15:02)
Big Idea 2
Big Idea 3
1.C.3.b
3.C.1.d
1.A.2.c,d
1.C.3.b
1.C.3.b
3.C.1.d
1.C.3.b
3.C.3.a,b
1.C.3.b
3.C.3.a,b
3.C.3.a,b
Big Idea 4
4.B.3.a
4.B.3.a
Viral infection explained. (15:02-19:33)
4.B.3.a
When a malaria-carrying mosquito bites a human host, the malaria
parasite enters the bloodstream, multiplies in the liver cells, and is
released into the bloodstream, where it infects and destroys red blood
cells. (4 min. 17 sec.)
A mosquito becomes infected with malaria when it sucks the blood from
an infected human. Once inside the mosquito, the parasites reproduce in
the gut and accumulate in the salivary glands, ready to infect another
human host with the next bite. (3 min. 59 sec.)
1.C.3.b
Lecture
Lecture 4: Emerging Infections:
How Epidemics Arise, Ch. 4-5
How do new epidemics arise? (6:47-9:26)
Lecture
Lecture 4: Emerging Infections:
How Epidemics Arise, Ch. 6-11
Genetics changes in viruses: mutation and recombination. (9:26-15:23)
Lecture
Lecture 4: Emerging Infections:
How Epidemics Arise, Ch. 12-19
Influenza epidemics and pandemics. (15:23-25:52)
Use HHMI resources to teach: The AP® Biology Course Curriculum
4.B.3.a
1.A.1.c
1.C.3.b
1.C.3.b
Page 46 of 54
3.A.1.c,d
3.C.1.a,b,d
3.C.2.a,b
3.C.3.a,b
4.B.3.a,b,c
4.B.4.a
4.B.1.a
4.B.4.a
4.B.3.a,b,c
4.B.4.a
Holiday Lectures on Science DVD: Of Hearts and Hypertension: Blazing Genetic Trails, 1998.
BioInteractive Website Topic: Cardiovascular
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
Lecture 2: Telltale Genes: Charting
3.A.1.a,c
Lecture
How genetics relates to disease. (5:58-11:37)
Human Disease, Ch. 2
3.A.3.c
Lecture 2: Telltale Genes: Charting
3.A.3.a
Lecture
Mendel, Morgan, and the dawn of genetics. (11:37-18:27)
Human Disease, Ch. 3
3.A.4.a
3.A.1.a
3.A.2.b,c
Lecture 2: Telltale Genes: Charting
Lecture
Gene linkage, chromosomes, and recombination. (18:27-25:13)
3.A.3.b
Human Disease, Ch. 4
3.C.1.d
3.C.2.b.c
Lecture 2: Telltale Genes: Charting
3.A.1.a,b,c,d
Lecture
Discovery of DNA as the genetic material. (25:13-31:01)
Human Disease, Ch. 5
3.A.3.a,b,c
Lecture 2: Telltale Genes: Charting
Lecture
Dominant and recessive inherited diseases. (31:01-37:47)
Human Disease, Ch. 6
Interactive
Click and
Learn
Lecture
Lecture
The Vertebrate Circulatorium
Lecture 1: Brave Heart: Circle of
Life, Ch. 2
Lecture 1: Brave Heart: Circle of
Life, Ch. 3
Kidney Function
Video
In the Vertebrate Circulatorium you can compare the circulation patterns
of different vertebrates.
2.D.2.c
Normal heart structure and function. (8:21-13:25)
2.D.2.a,c
The circulatory system and hemodynamics. (13:25-17:59)
Dr. Richard Lifton, along with student volunteers, uses an aquarium and
salt to illustrate the amount of work the kidney performs each day to
maintain proper levels of ions in the body. (4 min. 29 sec.)
Lecture
Lecture 4: The Kidney’s Tale: Of
Salt and Hypertension, Ch. 2
Definition of blood pressure. (7:04-14:41)
Lecture
Lecture 4: The Kidney’s Tale: Of
Salt and Hypertension, Ch. 3
The kidney’s role in hypertension. (14:41-23:06)
Use HHMI resources to teach: The AP® Biology Course Curriculum
2.D.2.a,c
2.D.2.a,b,c
2.D.2.a,c
2.D.2.a,b,c
Page 47 of 54
Big Idea #4
Resource
Type
Lecture
Resource Title
Lecture 4: The Kidney’s Tale: Of
Salt and Hypertension, Ch.5-6
AP Biology Correlations
Resource Summary
Big Idea 1
Genetic disorders in the sodium regulation pathway. (28:55-43:27)
Big Idea 2
2.C.1.a,c
2.D.2.a,b,c
2.D.3.a
Big Idea 3
Big Idea 4
3.D.2.c
3.D.4.a
Holiday Lectures on Science DVD: Senses and Sensitivity: Neuronal Alliances for Sight and Sound, 1997.
BioInteractive Website Topic: Neuroscience
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
2.B.1.b
3.D.2.b
The Neurophysiology Lab
Record electrical activities of neurons while you deliver mechanical
Virtual
2.B.2.a
3.E.2.a,b,c
stimulus to the attached skin. Identify the neurons based on the
Lab
morphology and response to stimuli, comparing them to published results.
3.E.2.d
Lecture
Lecture 1: Sensory Transduction:
Getting the Message, Ch. 4
Genetic differences in taste reception. (22:11-27:56)
Lecture
Lecture 1: Sensory Transduction:
Getting the Message, Ch. 5
The olfactory system. (27:56-34:02)
Lecture
Lecture 1: Sensory Transduction:
Getting the Message, Ch. 6
Encoding the signal and transmission to the brain. (34:02-39:00)
Lecture
Lecture 2: The Science of Sight:
Getting the picture, Ch. 2
Contrasting an eye to how a camera works. (5:45-10:21)
Lecture
Lecture
Lecture
Animation
Lecture 2: The Science of Sight:
Getting the picture, Ch. 3
Lecture 2: The Science of Sight:
Getting the picture, Ch. 4
Lecture 2: The Science of Sight:
Getting the picture, Ch. 7
The Cochlea
3.E.2.d
3.E.2.a,b,c,d
3.E.2.d
3.E.2.d
Light and dark sensitivity in vision. (10:21-15:21)
3.E.2.d
What happens in a photoreceptor cell? (15:21-22:56)
Variations in color receptors and color blindness. (41:07-47:26)
A dramatic illustration of how hearing happens in the ear. Includes audio
narration. (1 min. 30 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
2.B.2.a
Page 48 of 54
3.E.2.d
3.D.1.d
3.D.3.a,b
3.E.2.d
Big Idea #4
Resource
Type
Resource Title
AP Biology Correlations
Resource Summary
Big Idea 1
Lecture
Lecture 3: The Science of Sound:
How hearing happens, Ch. 3-4
Structure and function of the ear’s hair cells. (15:29-27:56)
Lecture
Lecture 3: The Science of Sound:
How hearing happens, Ch. 5
Converting hair cell motion to an electrical signal. (27:56-40:24)
Lecture
Lecture 4: Neural Processing:
Making sense of sensory
information, Ch. 2
The visual and auditory cortexes of the brain. (7:10-11:24)
Big Idea 2
Big Idea 3
Big Idea 4
3.D.1.d
3.D.3.a,b
3.E.2.d
3.D.1.d
3.D.3.a,b
3.E.2.a,b,c,d
3.D.1.d
3.D.3.a,b
3.E.2.d
Holiday Lectures on Science DVD: The Double Life of RNA, 1995.
BioInteractive Website Topic: RNA
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1.B.1.a
2.C.1.a
3.A.1.a,b,c,d
Gene Expression
Topics include: Gene Expression, RNA Structure and Function, Transcription,
2.E.1.a,b
3.B.1.a,b,c
Teacher
RNA Processing, Translation, and Post-translational Events The teacher guides
3.C.1.a,b,d
Guide
were developed to provide topic-specific organization of resources.
3.C.2.a
Teacher
Guide
Teacher
Guide
Interactive
Click and
Learn
Biotechnology
Topics include: PCR, DNA Sequencing, Genetic Engineering, and Microarrays.
The teacher guides were developed to provide topic-specific organization of
resources.
Gene Regulation
Topics include: Gene Regulation Mechanisms, Examples, and Human Disease,
and RNA Interference. The teacher guides were developed to provide topicspecific organization of resources.
RNA Diversity
RNA is an information molecule that can also function as an enzyme. Learn
about the many different forms that RNA can take and their roles. (11 slides)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 49 of 54
Big Idea #4
4.A.1.a,b
4.A.2.a
4.A.3.a,b,c
4.B.1.a
3.A.1.a,b,c,d,e
1.B.1.a
2.C.1.a
2.E.1.a,b
1.B.1.a
1.D.1.a
2.C.1.a
2.E.1.a,b
3.A.1.a,b,c,d
3.B.1.a,b,c
3.C.1.a,b,d
3.C.2.a
3.A.1.a,b,c,d
3.B.1.a,b,c
3.C.1.a,b,d
3.C.2.a
4.A.1.a,b
4.A.2.a
4.A.3.a,b,c
4.B.1.a
4.A.1.a,b
4.A.2.a
4.A.3.a,b,c
Resource
Type
Resource Title
RNA Folding
Animation
AP Biology Correlations
Resource Summary
Big Idea 1
Since RNA is single-stranded, it can fold upon itself and form structures that
are protein-like in both appearance and functionality. (32 sec.)
Lecture
Lecture 1: Catalysis, Chemical
and Biochemical, Ch. 9-12
RNA as an information carrier and an enzyme. (20:00-28:14)
This segment of lecture reviews the roles of DNA, RNA, and proteins in the
gene expression pathway,
Lecture
Lecture 2: RNA as an Enzyme:
Discovery, Origins of Life, and
Medical Possibilities, Ch. 3-5
Review of RNA’s dual nature. (2:47-10:20)
This portion of the material reviews the roles of RNA in gene expression.
Video
Enzymes that are Not Proteins:
The Discovery of Ribozymes
Listen to former HHMI President Dr. Thomas Cech discussing his Nobel Prize–
winning discovery of RNA's catalytic properties. (19 min.)
Big Idea 2
1.B.1.a
Big Idea 3
Big Idea 4
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a
1.D.1.a
2.C.1.a
3.A.1.a,b,c
3.C.1.a,b
4.A.1.a,b
1.B.1.a
1.D.1.a
2.C.1.a
3.A.1.a,b,c
3.C.1.a,b
4.A.1.a,b
1.B.1.a
1.D.1.a
2.C.1.a
3.A.1.a,b,c
3.C.1.a,b
4.A.1.a,b
Why study the protozoan Tetrahymena and RNA Splicing. (12:28-28:33)
This portion of the lecture explains the details of RNA splicing following DNA
transcription.
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
Lecture
Lecture 2: RNA as an Enzyme:
Discovery, Origins of Life, and
Medical Possibilities, Ch. 7-12
Outline of the lecture and the biochemical mechanism of RNA splicing.
(7:14-21:05) This lecture segment discusses the biochemical mechanism of
RNA splicing along with the catalytic nature of RNA.
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
Lecture
Lecture 3: How to Accelerate a
Reaction 100 Billion Times
Using Only RNA, Ch. 4-8
NOVA Science NOW: RNAi
Video
Interactive
Click and
Learn
Lecture
Structure and Function of
Telomeres
Lecture 4: Life at the End of the
Chromosome: Another RNA
Machine, Ch. 3-9
A story from the PBS science newsmagazine detailing RNAi’s (RNA
Interference) discovery and how it functions. (15 min. 18 sec.)
1.B.1.a
1.D.1.a
2.C.1.a
3.A.1.a,b,c
3.C.1.a,b
4.A.1.a,b
1.B.1.a
2.C.1.a
3.A.1.a,b,c
3.C.1.a,b
3.C.2.a
4.A.1.a,b
1.B.1.a
2.C.1.a
3.A.1.a,b,c
3.C.1.a,b
3.C.2.a
4.A.1.a,b
This mini-lesson covers the research on telomeres that has happened since
the 1995 Holiday Lectures. (17 slides)
DVD Resource Title: Telomeres Revisited
Human Chromosomes and their Replication and Telomeres.
(2:03-22:57) This segment includes a detailed look at DNA replication in
humans and the function of telomeres at the end of eukaryotic chromosomes.
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 50 of 54
Resource
Type
Resource Title
Lecture
Lecture 4: Life at the End of the
Chromosome: Another RNA
Machine, Ch. 10-17
Lecture
Lecture 2: RNA as an Enzyme:
Discovery, Origins of Life, and
Medical Possibilities, Ch. 12
AP Biology Correlations
Resource Summary
Big Idea 1
1.B.1.a
Replication Problems at the Ends of the DNA Strand. (22:57-46:14)
The lecture material here explains the problem associated with telomeres and
the role of the enzyme telomerase while connecting the concepts with
research methods.
Big Idea 2
2.C.1.a
1.B.1.a
Big Idea 3
Big Idea 4
3.A.1.a,b,c
3.C.1.a,b
3.C.2.a
4.A.1.a,b
3.A.1.a,b,c
4.A.1.a,b
Recombinant E. coli shows RNA can splice itself. (25:52-28:33)
BioInteractive Website Topic: DNA (NOTE: these resources are NOT available on DVD but can be downloaded from BioInteractive.org)
All of these resources can be accessed via www.BioInteractive.org and via Holiday Lectures on Science DVD’s.*
If you have downloaded this document from Biointeractive.org, simply click on the title or thumb print photos within each resource row to open the resource.
Resource
AP Biology Correlations
Resource Title
Resource Summary
Big Idea #1
Big Idea #2
Big Idea #3
Type
1.B.1.a
2.C.1.a
3.A.1.a,b,c,d
DNA
Topics include: DNA Structure and Function, DNA Replication, Damage to DNA
2.E.1.a,b
3.B.1.a,b,c
Teacher
and Eukaryotic Chromosomal Structure. The teacher guides were developed to
3.C.1.a,b,d
Guide
provide topic-specific organization of BioInteractive resources.
3.C.2.a
Teacher
Guide
Teacher
Guide
Teacher
Guide
1.B.1.a
Gene Expression
Topics include: Gene Expression, RNA Structure and Function, Transcription,
RNA Processing, Translation, and Post-translational Events The teacher guides
were developed to provide topic-specific organization of resources.
Biotechnology
Topics include: PCR, DNA Sequencing, Genetic Engineering, and Microarrays.
The teacher guides were developed to provide topic-specific organization of
BioInteractive resources.
Gene Regulation
Topics include: Gene Regulation Mechanisms, Examples, and Human Disease,
and RNA Interference. The teacher guides were developed to provide topicspecific organization of BioInteractive resources.
3.A.1.a,b,c,d
3.B.1.a,b,c
3.C.1.a,b,d
3.C.2.a
4.A.1.a,b
4.A.2.a
4.A.3.a,b,c
4.B.1.a
3.A.1.a,b,c,d,e
1.B.1.a
Use HHMI resources to teach: The AP® Biology Course Curriculum
2.C.1.a
2.E.1.a,b
Big Idea #4
4.A.1.a,b
4.A.2.a
4.A.3.a,b,c
4.B.1.a
Page 51 of 54
2.C.1.a
2.E.1.a,b
3.A.1.a,b,c,d
3.B.1.a,b,c
3.C.1.a,b,d
3.C.2.a
4.A.1.a,b
4.A.2.a
4.A.3.a,b,c
4.B.1.a
Resource
Type
Resource Title
Building Blocks of DNA
Animation
Chargaff’s Ratio
Animation
Animation
Watson Constructing Base
Pair Models
Big Idea 1
Adenine (A), cytosine (C), guanine (G), and thymine (T) are the components of
nucleotides that make up DNA. (26 sec.)
In 1950, Erwin Chargaff published a paper stating that in the DNA of any given
species, the ratio of adenine to thymine is equal, as is the ratio of cytosine to
guanine. (48 sec.)
During the process of trying to elucidate the structure of DNA, Jim Watson
made some cardboard models to try to understand how DNA nucleotides are
paired. (1 min. 42 sec.)
Paired DNA Strands
DNA has a double helix structure. If untwisted, DNA looks like two parallel
strands. Each strand has a linear sequence of A, C, G, and T. One strand is a
complementary image of the other. (1 min. 18 sec.)
Coding Sequence in DNA
Of the 3 billion letters in the human genome, only 1% directly code for
proteins. Of the rest, about 25% make up genes and their regulatory elements.
(1 min. 4 sec.)
Animation
Animation
DNA Packaging
Animation
Human Chromosomes
Animation
DNA Replication (schematic)
Animation
DNA Replication (basic)
Animation
AP Biology Correlations
Resource Summary
DNA wraps around special proteins called histones, which form loops of DNA
called nucleosomes. These nucleosomes coil and stack together to form fibers
called chromatin. Chromatin in turn forms larger loops and coils to form
chromosomes. (1 min. 43 sec.)
The human genome is organized into structures called chromosomes,
consisting of 22 matching pairs and one pair of sex chromosomes. (47 sec.)
Big Idea 3
Big Idea 4
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a,b
3.A.1.a,b,c
4.A.1.a,b
1.B.1.a,b
3.A.1.a,b,c
3.A.4.b
3.B.2.a
4.A.1.a,b
1.B.1.a
3.A.1.a,b
3.C.1.a,b
4.A.1.a,b
1.B.1.a
3.A.1.a,b
3.C.1.a,b
4.A.1.a,b
The structure of DNA, discovered by James Watson and Francis Crick, suggests
a mechanism of replication. (50 sec.)
Using information from molecular research, this 3-D animation shows how
DNA is replicated at the molecular level. (1 min. 6 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Big Idea 2
1.B.1.a
Page 52 of 54
Resource
Type
Resource Title
Big Idea 2
Big Idea 3
Big Idea 4
3.A.1.a,b
3.C.1.a,b
4.A.1.a,b
1.B.1.a
4.A.1.a,b
1.B.1.a
3.A.1.a,b
3.C.1.a,b
3.C.2.a
3.D.1.d
3.A.1.a,b,c
The first phase of the process of reading DNA information to make proteins
starts with a molecule unzipping the DNA. The molecule then copies one of the
strands of DNA into a strand of RNA, a close cousin of DNA. This process is
called transcription. (1 min. 54 sec.)
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
DNA Transcription
(Advanced)
Transcription factors assemble at the promoter region of a gene, bringing an
RNA polymerase enzyme to form the transcription initiation complex. RNA
polymerase unzips a small portion of the DNA and copies one strand into an
mRNA molecule. (1 min. 55 sec.)
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
mRNA Splicing
Once a gene has been transcribed into messenger RNA (mRNA), it is edited in a
process called splicing. Noncoding regions called introns are removed, leaving
protein-coding regions called exons. (39 sec.)
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
Translation(Basic)
Inside the ribosome, the genetic code of the RNA is read three letters at a time
and compared with the corresponding code on a transfer molecule.
(2 min. 5 sec.)
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
4.A.2.a
Translation (Advanced)
Messenger RNA (mRNA) carries DNA’s genetic information to the ribosome,
where it is translated into a sequence of amino acids. mRNA is fed into the
ribosome, and it is positioned so that it can be read in groups of three letters,
known as codons. (3 min. 4 sec.)
1.B.1.a
3.A.1.a,b,c
4.A.1.a,b
4.A.2.a
Animation
Mismatch Repair
Animation
Triplet Code
Animation
DNA Transcription (Basic)
Animation
Animation
Animation
Animation
Big Idea 1
1.B.1.a
DNA Replication (advanced)
Animation
AP Biology Correlations
Resource Summary
Both strands of the DNA double helix act as templates for the new DNA
strands. The 3′ strands and the 5′ strands are replicated by a DNA polymerase
enzyme but in different ways. (2 min. 32 sec.)
This animation illustrates how mistakes made during DNA replication are
repaired. (1 min. 22 sec.)
4.A.1.a,b
Once the structure of DNA was discovered, the next challenge was determining
how the sequence of letters coded for the 20 amino acids. (1 min. 8 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 53 of 54
Resource
Type
Animation
Resource Title
Damage to DNA Leads to
Mutation
Sickle Cell Anemia
Animation
Trinucleotide Repeat
Animation
Big Idea 3
Big Idea 4
3.A.1.a,b
3.C.1.a,b
3.C.2.a
4.A.1.a,b
4.B.1.a
1.B.1.a
3.A.1.a,b
3.C.1.a,b
3.C.2.a
4.A.1.a,b
4.B.1.a
1.B.1.a
3.A.1.a,b
3.C.1.a,b
3.C.2.a
4.A.1.a,b
4.B.1.a
Reactive molecules and solar ultraviolet radiation can lead to mutations in
DNA. Most mutations are corrected, but in rare cases mutations can
accumulate and cause diseases such as cancer. (1 min 6 sec.)
Sickle cell anemia is a genetic disease. A single nucleotide change in the
hemoglobin gene causes an amino acid substitution in the hemoglobin protein
from glutamic acid to valine. The proteins stick together to form long fibers
and distort the shape of the red blood cells. (59 sec.)
Big Idea 2
1.B.1.a
Slippage during DNA replication can lead to expanding sections of repeating
nucleotides. Watch to see how this problem occurs. (1 min. 7 sec.)
A new gene can be inserted into a loop of bacterial DNA called a plasmid. The
genetically engineered bacteria will now manufacture any protein coded by
genes on the newly inserted DNA. (1 min. 12 sec.)
1.B.1.a
3.A.1.a,b,c,e
4.A.1.a,b
Polymerase Chain Reaction
Polymerase chain reaction, or PCR, is a technique for making many copies of a
specific DNA sequence. In as few as 30 cycles, a billion copies of the target
sequence can be made. (1 min. 27 sec.)
1.B.1.a
3.A.1.a,b,c,e
3.C.1.a,b
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c,e
3.C.1.a,b
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c,e
3.C.1.a,b
4.A.1.a,b
1.B.1.a
3.A.1.a,b,c,e
3.C.1.a,b
4.A.1.a,b
Animation
Sanger Method of DNA
Sequencing
Human Genome Sequencing
Animation
Shotgun Sequencing
Animation
Big Idea 1
Genetic Engineering
Animation
Animation
AP Biology Correlations
Resource Summary
Fred Sanger developed the first technique for sequencing DNA. DNA is
replicated in the presence of chemically altered versions of the A, C, G, and T
bases. (51 sec)
The public Human Genome Project started by identifying unique marker
sequences distributed throughout the genome. Then, many copies of a small
section of DNA were randomly cleaved into smaller fragments, and each small
fragment was sequenced. (1 min. 48 sec.)
In shotgun sequencing many copies of the entire genome are “blown up” into
millions of small fragments. Each small fragment is sequenced. Powerful
computers then assemble the individual fragments into the original
configuration. (59 sec.)
Use HHMI resources to teach: The AP® Biology Course Curriculum
Page 54 of 54