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Transcript
From: Gene Regulatory Control of Myocardial Energy Metabolism Predicts Postoperative Cardiac Function in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery:Inhalational versusIntravenous Anesthetics Anesthes. 2007;106(3):444-457. Figure Legend: Fig. 3. ( A ) Pathways (gene sets) up-regulated and down-regulated at T2 in response to off-pump coronary artery bypass graft surgery in the two anesthetic treatments. The Venn diagrams show the number of enriched pathways (see also table 4). ( B ) Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) pathway activity at baseline (t = T1). Each numbered square indicates the expression value of the indicated transcript in a specific patient. Subtle differences (approximately 15%) in PGC-1α activity were detected among patients. ( C ) PGC-1α pathway regulates genes involved in oxidative phosphorylation (OXPHOS) and acid (FA)5/4/2017 metabolism and was therefore used to express background energy metabolism in the heart (see also fig. S2 on Datefatty of download: Copyright © 2017 American Society of Anesthesiologists. All rights reserved. the Anesthesiology Web site). CaMK II β= calcium/calmodulin-dependent protein kinase II β; CaMK II γ= calcium/calmodulin-