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From: Gene Regulatory Control of Myocardial Energy Metabolism Predicts Postoperative Cardiac Function in Patients
Undergoing Off-pump Coronary Artery Bypass Graft Surgery:Inhalational versusIntravenous Anesthetics
Anesthes. 2007;106(3):444-457.
Figure Legend:
Fig. 3. ( A ) Pathways (gene sets) up-regulated and down-regulated at T2 in response to off-pump coronary artery bypass graft
surgery in the two anesthetic treatments. The Venn diagrams show the number of enriched pathways (see also table 4). ( B )
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) pathway activity at baseline (t = T1). Each numbered square
indicates the expression value of the indicated transcript in a specific patient. Subtle differences (approximately 15%) in PGC-1α
activity were detected among patients. ( C ) PGC-1α pathway regulates genes involved in oxidative phosphorylation (OXPHOS)
and
acid (FA)5/4/2017
metabolism and was
therefore
used
to express
background
energy metabolism
in the heart (see also fig. S2 on
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of download:
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the Anesthesiology Web site). CaMK II β= calcium/calmodulin-dependent protein kinase II β; CaMK II γ= calcium/calmodulin-