Download Protein or gene

Supplemental Data Table 1. Low abundance proteins, or proteins not previously seen in serum, identified in ovarian cancer sera.
Protein or gene
Function
Reference
P21-activated kinase 7
A member of the PAK family of Ser/Thr protein kinases. PAK family
Kumar R, Hung M-C.
members are known to be effectors of Rac/Cdc42 GTPases which have
Cancer Res
been implicated in the regulation of cytoskeletal dynamics proliferation and
2005;65:2511-2515.
cell survival signaling. Pak1 overexpression and hyperactivation have been
linked with the invasiveness of human breast cancer cells and breast tumors. Shiratsuchi T, Nishimori
Expression of Pak1 in breast tumor tissue correlates with tumor grade
H, Ichise H, Nakamura
showing higher expression in less differentiated ductal carcinomas of the
Y, Tokino T. Cytogenet
breast (grade 3 tumors) than in grade 2 and grade 1 tumors. Brain-specific
Cell Genet 1997;79:103-
angiogenesis inhibitor 3 (BAI3), is an angiogenesis inhibitor that is a
108.
candidate for involvement in the development of glioblastoma.
The glypicans
Compose a family of glycosylphosphatidylinositol-anchored heparan sulfate Veugelers M, De Cat B,
proteoglycans that may play a role in the control of cell division and growth
Delande N, Esselens C,
regulation. Glypican 5 (GPC5) was over-expressed in lymphoma cell lines
Bonk I, Vermeesch J,
that had shown amplification in comparison with those that had not. The
Marynen P, Fryns JP,
findings suggested that GPC5 is a likely target for amplification and that
David G. Biol
over-expression of this gene may contribute to development and/or
2001;20:375-385.
progression of lymphomas and other tumors.
Yu W, Inoue J, Imoto I,
Matsuo Y, Karpas A,
Inazawa J J Hum Genet
2003;48:331-335.
26S proteasome
Consists of the 20S core and 19S regulatory complexes; regulates
Thompson HG, Harris
intracellular protein concentration through proteolytic degradation of
JW, Brody JP. Int J
targeted substrates. Aberrant activity of the 26S proteasome affects the cell
Cancer. 2004;111:338-
cycle, apoptosis and other cellular processes related to cancer. TBP-1 is a
347.
component of the 19 S regulatory subunit of the proteasome 26 S. DNA
homology suggests that an apparent part of TBP-1 has been obtained as a
Pollice A, Nasti V,
BRCA1 locus-related gene (OV-4) and mapped onto chromosome 17q12–
Ronca R, Vivo M, Lo
21. Interestingly, the nucleotide structure of human TBP-1 is very similar to
Iacono M, Calogero R,
that of the GT198 gene which has been cloned from a human breast cancer
Calabro V, La Mantia G..
cell line and also mapped onto the BRCA1 locus. TBP-1 specifically
J Biol Chem.
interacts with ARF, a tumor suppressor and a key regulator of cellular
2004;279:6345-6353.
proliferation that is frequently inactivated in human cancer. Overexpression
Granzyme H
of TBP-1 in various cell lines results in a sharp increase of ARF protein
Ijichi H, Tanaka T,
levels and this overexpression results in an increase in p53 protein levels
Nakamura T, Yagi H,
and activity, underlining a clear involvement of TBP-1 in the control of cell
Hakuba A, Sato M.
proliferation.
Gene. 2000;248:99-107.
A member of the granzyme family of serine proteases stored in the
Haddad P, Jenne D,
cytoplasmic granules of CTLs NK and LAK cells. These molecules are
Tschopp J, Clement MV,
involved in cytotoxic T lymphocyte (CTL) natural killer (NK) and
Mathieu-Mahul D,
lymphokine activated killer (LAK) cell-mediated lysis. Granzyme H plays a
Sasportes M. Int
role in complementing the pro-apoptotic function of granzyme B in human
Immunol 1991;1:57-66.
NK cells.
Sedelies KA, Sayers TJ,
Edwards KM, Chen W,
Pellicci DG, Godfrey DI,
Trapani JA. J Biol Chem.
2004;279:26581-26587.
CREB-Binding protein
Interacts with coactivator p300 and the breast cancer susceptibility gene
Crowe DL, Lee MK.
BRCA1 to activate target gene transcription, (56)
Breast Cancer Res.
2006;8:R1.
NOTCH
Headcase (hHDC) gene
NOTCH-ligand interaction regulates specific cell fate decision during
Miele L, Miao H,
development. Studies indicate that NOTCH activation plays a role in the
Nickoloff BJ. Curr
onset and progression of many human malignancies, in addition to its
Cancer Drug Targets.
functions in developmental and cell maturation processes.
2006;6:313-323.
May play an important role in some human cancers as a tumor suppressor.
Makino N, Yamato T,
The hHDC gene was isolated from 6q24, a commonly deleted region on
Inoue H, Furukawa T,
chromosome 6. Deletions from the long arm of chromosome 6 are one of
Abe T, Yokoyama T,
the most common chromosomal abnormalities in multiple human
Yatsuoka T, Fukushige
malignancies, including pancreatic cancer.
S, Orikasa S, Takahashi
T, Horii A. DNA Seq
2001;11:547-553.
SET binding protein (SEB)
Located on chromosome 18q21.1 that contains candidate tumor suppressor
Minakuchi M, Kakazu N,
gene
genes associated with deletions in cancer and leukemia. Although the
Gorrin-Rivas MJ, Abe T,
function of SEB is not known, it has been speculated that SEB plays a key
Copeland TD, Ueda K,
role in the mechanism of SET-related leukemogenesis and tumorigenesis.
Adachi Y. Eur J Biochem
2001;268:1340-1351.