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Stem Cell Therapy Reverses Diabetes: Stem Cells from Cord Blood
Used to Re-Educate Diabetic's Own T Cells
ScienceDaily (Jan. 9, 2012) — Type 1 diabetes is
caused by the body's own immune system
attacking its pancreatic islet beta cells and requires
daily injections of insulin to regulate the patient's
blood glucose levels. A new method described in
BioMed Central's open access journal BMC
Medicine uses stem cells from cord blood to reeducate a diabetic's own T cells and consequently
restart pancreatic function reducing the need for
insulin.
See Also:
Health & Medicine
• Immune System
• Stem Cells
• Diabetes
• Hypertension
• Lymphoma
• Anemia
Stem Cell Educator therapy slowly
passes lymphocytes separated from
a patient's blood over immobilized
cord blood stem cells (CBSC) from
healthy donors. After two to three
hours in the device the re-educated
lymphocytes are returned to the
patient. The progress of the patients
was checked at 4, 12, 24 and 40
weeks after therapy.
Reference
• Diabetes mellitus
type 1
• Blood sugar
• Diabetes mellitus
type 2
• Natural killer cell
C-peptide is a protein fragment made
as a by-product of insulin
manufacture and can be used to
determine how well beta cells are
working. By 12 weeks after treatment
all the patients who received the
therapy had improved levels of Cpeptide. This continued to improve at
24 weeks and was maintained to the
end of the study. This meant that the daily dose of insulin
required to maintain their blood glucose levels could be
reduced. In accordance with these results the glycated
hemoglobin (HbA1C) indicator of long term glucose control also
dropped for people receiving the treatment, but not the control
group.
Dr Yong Zhao, from University of Illinois at Chicago, who led
the multi-centre research, explained: "We also saw an
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http://www.sciencedaily.com/releases/2012/01/120109211827.htm
6/26/2012
Page 2 of 3
improved autoimmune control in these patients. Stem Cell
Educator therapy increased the percentage of regulatory T
lymphocytes in the blood of people in the treatment group.
Other markers of immune function, such as TGF-beta1 also
improved. Our results suggest that it is this improvement in
autoimmune control, mediated by the autoimmune regulator
AIRE in the CBSC, which allows the pancreatic islet beta cells
to recover."
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Story Source:
The above story is reprinted from materials provided by
BioMed Central.
Note: Materials may be edited for content and length. For
further information, please contact the source cited above.
technique for turning embryonic stem cells into
insulin-producing pancreatic tissue in what could
prove a significant breakthrough in the quest to find
new treatments ... > read more
New Source Of Islet Cells For Islet
Transplantion For Type 1 Diabetes (Oct. 25,
2007) — Islets transplantation is one promising
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Journal Reference:
1. Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye,
Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao,
Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk,
Randal Skidgel, Mark Holterman, Bellur Prabhakar,
Theodore Mazzone. Reversal of type 1 diabetes via islet
beta cell regeneration following immune modulation by
cord blood-derived multipotent stem cells. BMC
Medicine, 2012; 10: 3 DOI: 10.1186/1741-7015-10-3
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BioMed Central (2012, January 9). Stem cell
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blood used to re-educate diabetic's own T cells.
ScienceDaily. Retrieved June 26, 2012, from
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