Title Slide
... differential diagnosis of polyuria-polydipsia syndrome! CT-proAVP is superior to the current method of choice and revives the concept of the direct test in the polyuria- polydipsia syndrome. Fenske W. et.al. Copeptin in the differential diagnosis of the polyuria- polydipsia syndrome – revisiting the ...
... differential diagnosis of polyuria-polydipsia syndrome! CT-proAVP is superior to the current method of choice and revives the concept of the direct test in the polyuria- polydipsia syndrome. Fenske W. et.al. Copeptin in the differential diagnosis of the polyuria- polydipsia syndrome – revisiting the ...
Immune profile from high-risk to onset of Type 1 diabetes No. 1275
... autoimmune attack on the insulin producing β-cells of the pancreas, leading to a lack of insulin secretion and life-long insulin treatment. The search for possible targets pin-pointing the β-cell destruction is a constant endeavour in the pursuit to prevent T1D onset. Hence, characterisation of the ...
... autoimmune attack on the insulin producing β-cells of the pancreas, leading to a lack of insulin secretion and life-long insulin treatment. The search for possible targets pin-pointing the β-cell destruction is a constant endeavour in the pursuit to prevent T1D onset. Hence, characterisation of the ...
curriculum vitae
... Idd4, is responsible for the IL-12p40 over-expression defect in non-obese diabetic (NOD) mice. J Immunol 171:3333. 12. Kim, H. J., J. P. Antel, P. Duquette, D. G. Alleva, P. J. Conlon, and A. Bar-Or. 2002. Persistence of immune responses to altered and native myelin antigens in patients with multipl ...
... Idd4, is responsible for the IL-12p40 over-expression defect in non-obese diabetic (NOD) mice. J Immunol 171:3333. 12. Kim, H. J., J. P. Antel, P. Duquette, D. G. Alleva, P. J. Conlon, and A. Bar-Or. 2002. Persistence of immune responses to altered and native myelin antigens in patients with multipl ...
Periodontal infection, impaired fasting glucose and impaired
... The current analysis includes men and women aged 30–80 years of age who received a periodontal examination and an oral glucose tolerance test (OGTT). Individuals were excluded if they had diabetes as determined via: (i) Self-reported, diabetes diagnosis; or (ii) HbA1c levels ≥6.5% or (iii) fasting g ...
... The current analysis includes men and women aged 30–80 years of age who received a periodontal examination and an oral glucose tolerance test (OGTT). Individuals were excluded if they had diabetes as determined via: (i) Self-reported, diabetes diagnosis; or (ii) HbA1c levels ≥6.5% or (iii) fasting g ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
... Homann, D., A. Tishon, D.P. Berger, W.O. Weigle, M.G. von Herrath, M.B.A. Oldstone. Evidence for an underlying CD4 helper and CD8 T cell defect in B cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from MT/MT mice. J. Vi ...
... Homann, D., A. Tishon, D.P. Berger, W.O. Weigle, M.G. von Herrath, M.B.A. Oldstone. Evidence for an underlying CD4 helper and CD8 T cell defect in B cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from MT/MT mice. J. Vi ...
Beta-cell function and mass in type 2 diabetes
... (IDF, 2000). The global prevalence of the disease was reported to be approximately 150 million or 3.8% of the adult population around year 2000 and is expected to increase to around 300 million or 5.1% of the adult population by year 2025, and this is most likely an underestimate (Green et al., 2003 ...
... (IDF, 2000). The global prevalence of the disease was reported to be approximately 150 million or 3.8% of the adult population around year 2000 and is expected to increase to around 300 million or 5.1% of the adult population by year 2025, and this is most likely an underestimate (Green et al., 2003 ...
STUDIES OF MUCOSAL IMMUNE REGULATION ANNE LAHDENPERÄ
... diseases with increasing incidence worldwide. A combination of genetic, environmental and immunological factors is considered to be involved in development of the diseases, even though the exact disease mechanisms still are unknown. CD and T1D are both believed to be associated with type 1 like immu ...
... diseases with increasing incidence worldwide. A combination of genetic, environmental and immunological factors is considered to be involved in development of the diseases, even though the exact disease mechanisms still are unknown. CD and T1D are both believed to be associated with type 1 like immu ...
Risk Factors for Foot Infections in Individuals With
... foot wound as a full skin thickness lesion involving any portion of the foot or ankle (25–27). Using a blunt sterile probe, we evaluated the depth of any wound to determine undermining and whether the wound penetrated to tendon, joint capsule, or bone. We also recorded the duration the wound had bee ...
... foot wound as a full skin thickness lesion involving any portion of the foot or ankle (25–27). Using a blunt sterile probe, we evaluated the depth of any wound to determine undermining and whether the wound penetrated to tendon, joint capsule, or bone. We also recorded the duration the wound had bee ...
4176 metodological instructions - Сумський державний університет
... underpin quality care by providing accurate and timely information on the results of individual patient treatment in real time, and facilitate the tracking of patients over time for purposes of continuous improvement of care for designated populations or sub-populations. It is also invaluable for pu ...
... underpin quality care by providing accurate and timely information on the results of individual patient treatment in real time, and facilitate the tracking of patients over time for purposes of continuous improvement of care for designated populations or sub-populations. It is also invaluable for pu ...
Role of ghrelin and leptin in the regulation of carbohydrate
... levels are also significantly higher in children with type 1 diabetes, and correlate with the above-mentioned factors and additionally with diabetes duration. Experimental studies showed that leptin insufficiency plays an important role in the pathogenesis of insulin resistance [8]. The leptin level ...
... levels are also significantly higher in children with type 1 diabetes, and correlate with the above-mentioned factors and additionally with diabetes duration. Experimental studies showed that leptin insufficiency plays an important role in the pathogenesis of insulin resistance [8]. The leptin level ...
Mechanisms underlying stress-induced hyperglycemia in critically ill
... Association between hyperglycemia and poor prognostic outcome following different types of acute illnesses (e.g., AMI, stroke, trauma and complex surgery) has been well established. Hyperglycemia may be associated with hypovolemia and trace element deficiencies, leading to serious complications [1]. ...
... Association between hyperglycemia and poor prognostic outcome following different types of acute illnesses (e.g., AMI, stroke, trauma and complex surgery) has been well established. Hyperglycemia may be associated with hypovolemia and trace element deficiencies, leading to serious complications [1]. ...
TLR2 and TLR4 expression on CD14++ and CD14+ monocyte
... and the metabolic syndrome17,18. The TLR up-regulation observed in T1DM patients is hypothesized to be induced by hyperglycaemia19. Upon stimuli, monocytes are capable of producing ...
... and the metabolic syndrome17,18. The TLR up-regulation observed in T1DM patients is hypothesized to be induced by hyperglycaemia19. Upon stimuli, monocytes are capable of producing ...
Simultaneous Detection of Circulating Autoreactive CD8 T
... and injected together with each synthetic peptide into a refolding buffer consisting of 100 mmol/l Tris (pH 8.0), 400 mmol/l arginine, 2 mmol/l EDTA, 5 mmol/l reduced glutathione, and 0.5 mmol/l oxidized glutathione. Refolded complexes were biotinylated by incubation for 2 h at 30°C with BirA enzyme ...
... and injected together with each synthetic peptide into a refolding buffer consisting of 100 mmol/l Tris (pH 8.0), 400 mmol/l arginine, 2 mmol/l EDTA, 5 mmol/l reduced glutathione, and 0.5 mmol/l oxidized glutathione. Refolded complexes were biotinylated by incubation for 2 h at 30°C with BirA enzyme ...
Reaching the Biological Cure - Diabetes Research Institute
... liver of patients with the most severe forms of type 1 diabetes. However, this transplant site is not ideal for taking the next step on the path to a biological cure by moving away from generalized treatment with anti-rejection drugs, toward local immunomodulation and immunoprotection of the transpl ...
... liver of patients with the most severe forms of type 1 diabetes. However, this transplant site is not ideal for taking the next step on the path to a biological cure by moving away from generalized treatment with anti-rejection drugs, toward local immunomodulation and immunoprotection of the transpl ...
Jenny Walldén Studies of immunological risk factors in type 1 diabetes
... regulatory T cells seemed also to be functional in children with T1D, since increased proliferation after depletion of CD4+CD25high cells from PBMC was demonstrated in T1D as well as in healthy children. However, T1D children did have more intracellular CTLA-4 per CD4+CD25high T cell, increased leve ...
... regulatory T cells seemed also to be functional in children with T1D, since increased proliferation after depletion of CD4+CD25high cells from PBMC was demonstrated in T1D as well as in healthy children. However, T1D children did have more intracellular CTLA-4 per CD4+CD25high T cell, increased leve ...
NIDDK Medical Student Research Symposium Student
... and Kidney Diseases (NIDDK) supports programs to encourage physicians to enter careers involving research. These programs offer first- and second-year medical students the opportunity to conduct mentored research. The research opportunities range from basic laboratory studies to clinical studies in ...
... and Kidney Diseases (NIDDK) supports programs to encourage physicians to enter careers involving research. These programs offer first- and second-year medical students the opportunity to conduct mentored research. The research opportunities range from basic laboratory studies to clinical studies in ...
Cannabidiol lowers incidence of diabetes in non - Alpha-CAT
... autoimmune joint destruction in the collagen-induced arthritis animal model of rheumatoid arthritis, a Th1-mediated disease [13]. The anti-autoimmune effects of CBD were associated with reduction in synovial cell TNF-a production, inhibition of reactive oxygen release from zymosan-stimulated neutrop ...
... autoimmune joint destruction in the collagen-induced arthritis animal model of rheumatoid arthritis, a Th1-mediated disease [13]. The anti-autoimmune effects of CBD were associated with reduction in synovial cell TNF-a production, inhibition of reactive oxygen release from zymosan-stimulated neutrop ...
Chemokines as Drug Targets in Type 1 Diabetes
... demonstrated expression of CXCL10 as well as CCL2 and CCL20 at week 8 of age in female NOD mice [12]. Interestingly in this study, in vivo treatment of mice with 1,25Dihydroxyvitamin D3 diminished the release of these chemokines in pancreatic islets and abrogated disease [12]. In another exciting st ...
... demonstrated expression of CXCL10 as well as CCL2 and CCL20 at week 8 of age in female NOD mice [12]. Interestingly in this study, in vivo treatment of mice with 1,25Dihydroxyvitamin D3 diminished the release of these chemokines in pancreatic islets and abrogated disease [12]. In another exciting st ...
The prevalence of specific causes for diabetes mellitus in cats
... Specific symptoms of Cushing patients are poorly controlled DM, polyphagia, dermatologic signs such as fragile, thin, easy to bruise and easily infected skin, patchy and asymmetrical alopecia, muscle wasting, increase in abdominal size, hepatomegaly, abnormally pigmented skin, recurrent upper respir ...
... Specific symptoms of Cushing patients are poorly controlled DM, polyphagia, dermatologic signs such as fragile, thin, easy to bruise and easily infected skin, patchy and asymmetrical alopecia, muscle wasting, increase in abdominal size, hepatomegaly, abnormally pigmented skin, recurrent upper respir ...
Table S2 Biomarker Functions discussed in Publications
... may increase the risks of diabetes and cardiovascular disease. Also involved in acute phase immune response mechanism as an anti-inflammatory agent Cholesterol Transport Apolipoprotein A-1 is the major constituent of high-density lipoprotein (HDL) cholesterol and participates in cholesterol metaboli ...
... may increase the risks of diabetes and cardiovascular disease. Also involved in acute phase immune response mechanism as an anti-inflammatory agent Cholesterol Transport Apolipoprotein A-1 is the major constituent of high-density lipoprotein (HDL) cholesterol and participates in cholesterol metaboli ...
The Imbalance of B-Lymphocyte Subsets in Subjects with Different
... plasma glucose FPG < 6 1 mmol/L and 2 hour plasma glucose < 7 8 mmol/L as NGT and FPG ≥ 6 1 mmol/L or 2 hour plasma glucose ≥ 7 8 mmol/L as IGR or prediabetes. Inclusive criteria of T2D were as follows: (1) with a typical history of hyperglycemia; (2) negative for any islet autoantibodies (glutamic ...
... plasma glucose FPG < 6 1 mmol/L and 2 hour plasma glucose < 7 8 mmol/L as NGT and FPG ≥ 6 1 mmol/L or 2 hour plasma glucose ≥ 7 8 mmol/L as IGR or prediabetes. Inclusive criteria of T2D were as follows: (1) with a typical history of hyperglycemia; (2) negative for any islet autoantibodies (glutamic ...
Thyroid autoimmunity and polyglandular endocrine syndromes
... lymphocyte leukemia, pulmonary hypertension and ocular and neurological impairment in the VogtKoyanagi-Harada syndrome can also be observed.6,13 Table 2 summarizes the prevalen ce of diverse manifestations of APECED. Hypoparathyroidism is present in 2/3 of patients, Addison’s disease and candidiasis ...
... lymphocyte leukemia, pulmonary hypertension and ocular and neurological impairment in the VogtKoyanagi-Harada syndrome can also be observed.6,13 Table 2 summarizes the prevalen ce of diverse manifestations of APECED. Hypoparathyroidism is present in 2/3 of patients, Addison’s disease and candidiasis ...
Keep your feet and skin healthy
... The National Diabetes Information Clearinghouse (NDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1978, the Clearinghouse prov ...
... The National Diabetes Information Clearinghouse (NDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1978, the Clearinghouse prov ...
Autoimmune Destruction of Pancreatic b Cells
... autoimmune process. b Cell autoantigens, macrophages, dendritic cells, B lymphocytes, and T lymphocytes have been shown to be involved in the pathogenesis of autoimmune diabetes. b Cell autoantigens are thought to be released from b cells by cellular turnover or damage and are processed and presente ...
... autoimmune process. b Cell autoantigens, macrophages, dendritic cells, B lymphocytes, and T lymphocytes have been shown to be involved in the pathogenesis of autoimmune diabetes. b Cell autoantigens are thought to be released from b cells by cellular turnover or damage and are processed and presente ...
Diabetes mellitus type 1
Diabetes mellitus type 1 (also known as type 1 diabetes, or T1D; formerly insulin-dependent diabetes or juvenile diabetes) is a form of diabetes mellitus that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger) and weight loss.The cause of diabetes mellitus type 1 is unknown. Type 1 diabetes can be distinguished from type 2 by autoantibody testing. The C-peptide assay, which measures endogenous insulin production, can also be used.Administration of insulin is essential for survival. Insulin therapy must be continued indefinitely and does not usually impair normal daily activities. People are usually trained to manage their diabetes independently; however, for some this can be challenging. Untreated, diabetes can cause many complications. Acute complications include diabetic ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include heart disease, stroke, kidney failure, foot ulcers and damage to the eyes. Furthermore, complications may arise from low blood sugar caused by excessive treatment.Diabetes mellitus type 1 accounts for between 5% and 10% of cases of diabetes. Globally, the number of people with DM type 1 is unknown, although it is estimated that about 80,000 children develop the disease each year. Within the United States the number of affected persons is estimated at one to three million. The development of new cases vary by country and region; the lowest rates appears to be in Japan and China with approximately 1 person per 100,000 per year; the highest rates are found in Scandinavia where it is closer to 35 new cases per 100,000 per year. The United States and northern Europe fall somewhere in between with 8-17 new cases per 100,000 per year.