Download Table S2 Biomarker Functions discussed in Publications

Table S2 Biomarker Functions discussed in Publications
Biomarker
Site found
Physiological/pathological role
The Raf kinase
inhibitor protein
(RKIP)
T Lymphocytes
10
Alpha-enolase
T Lymphocytes
3Hydroxyisobutyr
ate
dehydrogenase,
mitochondrial
APMAP
T Lymphocytes
a factor involved in several signalling
cascades, which can inhibit activation of
NF-kB, a transcription factor regulating a
number of immune genes
a glycolytic enzyme involved in many
processes, including the initiation of
disease conditions, acting as a
plasminogen surface receptor
a key enzyme in the valine oxidation
pathway
Adipocyte differentiation
12
an antioxidant enzyme involved in
controlling the redox cellular state
perhaps representing differentiating
steps of the immune reaction to PCOS
an aspartyl lysosomal protease involved
in various biological processes such as
apoptosis, angiogenesis and
proliferation
Antioxidant activity.
10
biomarker of ovarian cancers, adiposity,
may increase the risks of diabetes and
cardiovascular disease. Also involved in
acute phase immune response
mechanism as an anti-inflammatory
agent
Cholesterol Transport Apolipoprotein A-1
is the major constituent of high-density
lipoprotein (HDL) cholesterol and
participates in cholesterol metabolism by
extracting free cholesterol from
peripheral tissues, thus exerting a
cardioprotective effect by preventing lipid
accumulation in arterial walls
Cytoskeleton actin cytoskeleton plays an
important role in regulating the insulinmediated traffic of glucose transporter 4
vesicles to the adipocyte plasma
membrane,
down-regulation of the immune response
15
Glucose metabolism
12
Peroxiredoxin-1
Omental
Biopsies.
Adipose
T Lymphocytes
Cathepsin D
T Lymphocytes
Peroxiredoxin 2
isoform a
Omental
Biopsies.
Adipose
Serum
Haptoglobin
Proapolipoprotei
n ApoA1
Omental
Biopsies.
Adipose
Actin beta
Omental
Biopsies.
Adipose
an inactivating
cleavage
product of the
complement
component 4b,
Triosephosphate
isomerise
Serum
Omental
Biopsies.
Adipose
Reference
10
10
10
12
12
12
19
GSTM3
(glutathione Stransferase M3)
HSP47
Omental
Biopsies.
Adipose
ovarian
biopsies
Glutathione metabolism and an
antioxidant enzyme
12
implicated in the pathogenesis of fibrotic
diseases and collagen metabolism
14
complement
C4α3c chain
Serum
15
complement
C4γ chain
Serum
complement
C4α4c chain
Serum
apolipoprotein C-I
Serum from
Non Insulin
Resistant
PCOS Women
Serum from
Insulin
Resistant
PCOS Women
Omental
Biopsies.
Adipose
infertility, autoimmunity, coronary heart
disease, insulin resistance and insulin
dependent diabetes
infertility, autoimmunity, coronary heart
disease, insulin resistance and insulin
dependent diabetes
infertility, autoimmunity, coronary heart
disease, insulin resistance and insulin
dependent diabetes
inhibits lipoprotein metabolism in the liver
inhibits lipoprotein metabolism in the liver
17
Phospholipid binding may be a
compensatory mechanism against the
oxidative stress induced by chronic
inflammation. may also reflect the
apoptosis of adipocytes and
preadipocytes induced by the tumor
necrosis factor alpha (TNF-a) secreted
by these cells as a result of the
inflammatory process associated with
obesity
protect cells against apoptosis.
12
14
apolipoprotein C-I
Annexin V
15
15
17
14
10kda heat
shock protein,
mitochondrial
(Hsp10) (10 kDa
chaperonin)
Heat shock 27
kDa protein
(HSP 27)
ovarian
biopsies
Antithrombin
Follicular Fluid
protein chaperoning, steroidogenesis
and especially protection against
apoptosis. Suppresses reactive oxygen
species (ROS) generation
regulation of fibrinolysis and thrombosis
Fibrinogen
Follicular Fluid
regulation of fibrinolysis and thrombosis
Antithrombin-III
precursor (ATIII)
Fibrinogen,
alpha chain,
isoform alpha
preproprotein
Fibrinogen
gamma chain
precursor
Plasminogenrelated protein A
(Fragment)
Annexin A2
(Annexin II)
(Lipocortin II)
(Calpactin I
ovarian
biopsies
ovarian
biopsies
regulation of fibrinolysis and thrombosis
11
11
14
regulation of fibrinolysis and thrombosis
14
ovarian
biopsies
regulation of fibrinolysis and thrombosis
14
ovarian
biopsies
regulation of fibrinolysis and thrombosis
14
ovarian
biopsies
regulation of fibrinolysis and thrombosis
14
ovarian
biopsies
heavy chain)
Annexin A11
(Annexin XI)
(Calcyclinassociated
annexin 50)
Far upstream
element binding
protein 2 (FUSE
binding protein
2)
Far upstream
element binding
protein 1 (FUSE
binding protein
1)
Rho GDPdissociation
inhibitor 1
F-actin capping
protein alpha-1
subunit
Cofilin-1
ovarian
biopsies
regulation of fibrinolysis and thrombosis
14
ovarian
biopsies
regulation of metabolism
14
ovarian
biopsies
regulation of metabolism, regulator of
insulin function
14
T Lymphocytes
10
Glyoxylate
reductase/hydro
xypyruvate
reductase
Flotillin-1
ovarian
biopsies
regulation of the cytoskeleton structure
and might reflect the different functional
state of the immune cellular system
regulation of the cytoskeleton structure
and might reflect the different functional
state of the immune cellular system
regulation of the cytoskeleton structure
and might reflect the different functional
state of the immune cellular system
regulator of insulin function,
ovarian
biopsies
ovarian
biopsies
regulator of insulin function,
14
regulator of insulin function,
14
ovarian
biopsies
regulator of insulin function, removal of
homocysteine
14
T Lymphocytes
Similar regulation of has been described
in an in vitro model of insulin resistance
10
T Lymphocytes
Similar regulation of has been described
in an in vitro model of insulin resistance
10
T Lymphocytes
the following secreted peptides can be
generated by it by alternative proteolytic
processing: connective tissue-activating
peptide III, b-thromboglobulin and
neutrophil-activating peptide 2. These
peptides act as regulatory molecules of
the immune response
Transport
10
Malate
dehydrogenase,
mitochondrial
precursor
Methionine
adenosyltransfer
ase II, beta,
isoform 1
Protein
disulphideisomerase A3
Superoxide
dismutase
(Mn),mitochondr
ial (precursor)
Platelet basic
protein
(precursor)
Albumin
T Lymphocytes
T Lymphocytes
Omental
Biopsies.
Adipose
10
10
14
12