Diabetes Mellitus
... Responsible for Many of the Complications of Diabetes, Including Renal Failure and Blindness Arteriolosclerosis and capillary basement membrane thickening are characteristic vascular changes in diabetes. The frequent occurrence of hypertension contributes to the development of the arteriolar lesions ...
... Responsible for Many of the Complications of Diabetes, Including Renal Failure and Blindness Arteriolosclerosis and capillary basement membrane thickening are characteristic vascular changes in diabetes. The frequent occurrence of hypertension contributes to the development of the arteriolar lesions ...
Cell-mediated Response
... unusually large concentrations or are freed from their configuration in body. ...
... unusually large concentrations or are freed from their configuration in body. ...
SGLT-2 Inhibitors - Diabetes in Control
... MOA: Inhibition of SGLT2 reduces reabsorption of glucose in the kidney, resulting in increased urinary glucose excretion, with a consequent lowering of plasma glucose levels as well as weight loss. Blocks approximately 50-80 grams of glucose per day from being reabsorbed ...
... MOA: Inhibition of SGLT2 reduces reabsorption of glucose in the kidney, resulting in increased urinary glucose excretion, with a consequent lowering of plasma glucose levels as well as weight loss. Blocks approximately 50-80 grams of glucose per day from being reabsorbed ...
Pathophysiology of Type 1 Diabetes
... • IAA and GADA prevalence and levels have not changed • Increases in IA-2A, ZnT8A, and IA-2βA at diagnosis during a period of rising incidence suggest that the process leading to type 1 diabetes is now characterized by a more intense humoral autoimmune response ...
... • IAA and GADA prevalence and levels have not changed • Increases in IA-2A, ZnT8A, and IA-2βA at diagnosis during a period of rising incidence suggest that the process leading to type 1 diabetes is now characterized by a more intense humoral autoimmune response ...
cell Destruction
... • IAA and GADA prevalence and levels have not changed • Increases in IA-2A, ZnT8A, and IA-2βA at diagnosis during a period of rising incidence suggest that the process leading to type 1 diabetes is now characterized by a more intense humoral autoimmune response ...
... • IAA and GADA prevalence and levels have not changed • Increases in IA-2A, ZnT8A, and IA-2βA at diagnosis during a period of rising incidence suggest that the process leading to type 1 diabetes is now characterized by a more intense humoral autoimmune response ...
DM - Department of Community Medicine ACME Pariyaram
... • A heterogeneous group of diseases, characterized by a state of chronic hyperglycemia, resulting from a diversity of etiologies, environmental and genetic acting jointly • Insulin – hormone that controls glucose, fat and amino acid metabolism ...
... • A heterogeneous group of diseases, characterized by a state of chronic hyperglycemia, resulting from a diversity of etiologies, environmental and genetic acting jointly • Insulin – hormone that controls glucose, fat and amino acid metabolism ...
Diabetes mellitus
... Decreased insulin receptor number (type A) Immunity against insulin receptor (type B) Postreceptor signaling defects ...
... Decreased insulin receptor number (type A) Immunity against insulin receptor (type B) Postreceptor signaling defects ...
Perth Researchers Probe Diabetes Gene
... “In collaboration with other WA scientists, we have discovered that IL12B variants affect many other diseases, including severe asthma, HIV complications, cerebral malaria and some skin conditions. “Finding this common gene linking all these different diseases is exciting as it allows us to investig ...
... “In collaboration with other WA scientists, we have discovered that IL12B variants affect many other diseases, including severe asthma, HIV complications, cerebral malaria and some skin conditions. “Finding this common gene linking all these different diseases is exciting as it allows us to investig ...
New Study to Search for Diabetes "Signatures"
... Type 1 diabetes is caused by an immune response that goes wrong and whilst scientists do not yet know what causes this to happen, it is known that children who develop it have certain genes which make them susceptible. Professor Morahan’s previous research has found that different versions of the im ...
... Type 1 diabetes is caused by an immune response that goes wrong and whilst scientists do not yet know what causes this to happen, it is known that children who develop it have certain genes which make them susceptible. Professor Morahan’s previous research has found that different versions of the im ...
Pathophysiology of Type 1 Diabetes
... • Chronic autoimmune disorder occurring in genetically susceptible individuals – May be precipitated by environmental factors ...
... • Chronic autoimmune disorder occurring in genetically susceptible individuals – May be precipitated by environmental factors ...
i. justification for intensive diabetes control
... 2. pancreas: beta-cells create the hormone, insulin, required for glucose uptake 3. insulin-requiring tissues: (muscles, fat) B. Hormones: 1. Lowers plasma glucose: insulin 2. Elevates plasma glucose: glucagon, catecholamines, growth hormone, cortisol ...
... 2. pancreas: beta-cells create the hormone, insulin, required for glucose uptake 3. insulin-requiring tissues: (muscles, fat) B. Hormones: 1. Lowers plasma glucose: insulin 2. Elevates plasma glucose: glucagon, catecholamines, growth hormone, cortisol ...
Senate Bill 911 Care for Children with Diabetes Act
... Type I- Usually diagnosed in children and young adults. The body does not produce insulin Type 2- The body does not produce enough insulin or fails to properly use insulin Fast growing epidemic in young people. Related to family history of diabetes, weight gain, and sedentary lifestyle. ...
... Type I- Usually diagnosed in children and young adults. The body does not produce insulin Type 2- The body does not produce enough insulin or fails to properly use insulin Fast growing epidemic in young people. Related to family history of diabetes, weight gain, and sedentary lifestyle. ...
outline3985
... 2. pancreas: beta-cells create the hormone, insulin, required for glucose uptake 3. insulin-requiring tissues: (muscles, fat) B. Hormones: 1. Lowers plasma glucose: insulin 2. Elevates plasma glucose: glucagon, catecholamines, growth hormone, cortisol ...
... 2. pancreas: beta-cells create the hormone, insulin, required for glucose uptake 3. insulin-requiring tissues: (muscles, fat) B. Hormones: 1. Lowers plasma glucose: insulin 2. Elevates plasma glucose: glucagon, catecholamines, growth hormone, cortisol ...
NONINFECTIOUS DISEASE What is noninfectious disease
... overly sensitive to a foreign substance • An allergy develops in response to various foreign substances that set off reactions in the body. ...
... overly sensitive to a foreign substance • An allergy develops in response to various foreign substances that set off reactions in the body. ...
sample slides - Johns Hopkins Medicine
... • Establish framework for decision-making • Compare/contrast results from recent trials ...
... • Establish framework for decision-making • Compare/contrast results from recent trials ...
Endocrine Disorders
... High Blood Glucose (Hyperglycemia) In diabetes, blood glucose builds up for several possible reasons… ...
... High Blood Glucose (Hyperglycemia) In diabetes, blood glucose builds up for several possible reasons… ...
Endocrine Disorders
... insulin well (insulin resistant) › Ability for pancreas to make insulin decreases over time ...
... insulin well (insulin resistant) › Ability for pancreas to make insulin decreases over time ...
Diabetes - Life Science Academy
... This affects the cardiovascular system because it makes it harder for blood to circulate through the body. This can cause a tingling sensation in the legs from lack of blood. ...
... This affects the cardiovascular system because it makes it harder for blood to circulate through the body. This can cause a tingling sensation in the legs from lack of blood. ...
Why does the pancreas stop producing insulin? - humanphys-chan
... Body’s immune system attacks/destroys beta cells Autoimmune disease attacks body’s own cells Abnormally high blood sugar levels Lack of insulin=inability to use glucose for energy or control source glucose levels in blood ...
... Body’s immune system attacks/destroys beta cells Autoimmune disease attacks body’s own cells Abnormally high blood sugar levels Lack of insulin=inability to use glucose for energy or control source glucose levels in blood ...
Diabetes mellitus type 1
Diabetes mellitus type 1 (also known as type 1 diabetes, or T1D; formerly insulin-dependent diabetes or juvenile diabetes) is a form of diabetes mellitus that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger) and weight loss.The cause of diabetes mellitus type 1 is unknown. Type 1 diabetes can be distinguished from type 2 by autoantibody testing. The C-peptide assay, which measures endogenous insulin production, can also be used.Administration of insulin is essential for survival. Insulin therapy must be continued indefinitely and does not usually impair normal daily activities. People are usually trained to manage their diabetes independently; however, for some this can be challenging. Untreated, diabetes can cause many complications. Acute complications include diabetic ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include heart disease, stroke, kidney failure, foot ulcers and damage to the eyes. Furthermore, complications may arise from low blood sugar caused by excessive treatment.Diabetes mellitus type 1 accounts for between 5% and 10% of cases of diabetes. Globally, the number of people with DM type 1 is unknown, although it is estimated that about 80,000 children develop the disease each year. Within the United States the number of affected persons is estimated at one to three million. The development of new cases vary by country and region; the lowest rates appears to be in Japan and China with approximately 1 person per 100,000 per year; the highest rates are found in Scandinavia where it is closer to 35 new cases per 100,000 per year. The United States and northern Europe fall somewhere in between with 8-17 new cases per 100,000 per year.