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Page 1 of 3 Science News ... from universities, journals, and other research organizations Stem Cell Therapy Reverses Diabetes: Stem Cells from Cord Blood Used to Re-Educate Diabetic's Own T Cells ScienceDaily (Jan. 9, 2012) — Type 1 diabetes is caused by the body's own immune system attacking its pancreatic islet beta cells and requires daily injections of insulin to regulate the patient's blood glucose levels. A new method described in BioMed Central's open access journal BMC Medicine uses stem cells from cord blood to reeducate a diabetic's own T cells and consequently restart pancreatic function reducing the need for insulin. See Also: Health & Medicine • Immune System • Stem Cells • Diabetes • Hypertension • Lymphoma • Anemia Stem Cell Educator therapy slowly passes lymphocytes separated from a patient's blood over immobilized cord blood stem cells (CBSC) from healthy donors. After two to three hours in the device the re-educated lymphocytes are returned to the patient. The progress of the patients was checked at 4, 12, 24 and 40 weeks after therapy. Reference • Diabetes mellitus type 1 • Blood sugar • Diabetes mellitus type 2 • Natural killer cell C-peptide is a protein fragment made as a by-product of insulin manufacture and can be used to determine how well beta cells are working. By 12 weeks after treatment all the patients who received the therapy had improved levels of Cpeptide. This continued to improve at 24 weeks and was maintained to the end of the study. This meant that the daily dose of insulin required to maintain their blood glucose levels could be reduced. In accordance with these results the glycated hemoglobin (HbA1C) indicator of long term glucose control also dropped for people receiving the treatment, but not the control group. Dr Yong Zhao, from University of Illinois at Chicago, who led the multi-centre research, explained: "We also saw an Ads by Google Stem Cell Rejuvenation — Stem cell therapy center US-based autologous treatment www.the-stem-cell-center.com Stem Cell Transplants — Most Experience, Best Outcomes Fred Hutchinson Cancer Research Ctr SeattleCCA.org/StemCellTransplant 24/7 Diabetes Monitoring — Water-Resistant, Wireless Sensor Gives 24/7 Readings. Get Info Now! www.dexcom.com Stem Cells and Diabetes — Store Your Child's Tooth Today It Could Save Their Lives store-a-tooth.com/ Type 2 Diabetes Treatment — Have Type 2 Diabetes? Not Anymore Learn Treatments From Experts Now! ServiceMountain.com/Type-2-Diabetes Related Stories Neural Stem Cell Transplant May Tackle Diabetes (Oct. 6, 2011) — Researchers in Japan have discovered how a patient's neural stem cells could be used as an alternative source of the beta cells needed for a regenerative treatment for diabetes. The research reveals ... > read more Uterine Stem Cells Used to Treat Diabetes (Sep. 14, 2011) — Controlling diabetes may someday involve mining stem cells from the lining of the uterus, researchers report in a new study. The team treated diabetes in mice by converting cells from the uterine ... > read more Stem Cell Breakthrough Offers Diabetes Hope (Apr. 3, 2008) — Scientists have discovered a new http://www.sciencedaily.com/releases/2012/01/120109211827.htm 6/26/2012 Page 2 of 3 improved autoimmune control in these patients. Stem Cell Educator therapy increased the percentage of regulatory T lymphocytes in the blood of people in the treatment group. Other markers of immune function, such as TGF-beta1 also improved. Our results suggest that it is this improvement in autoimmune control, mediated by the autoimmune regulator AIRE in the CBSC, which allows the pancreatic islet beta cells to recover." Share this story on Facebook, Twitter, and Google: Like 235 45 9 Other social bookmarking and sharing tools: | 101 Story Source: The above story is reprinted from materials provided by BioMed Central. Note: Materials may be edited for content and length. For further information, please contact the source cited above. technique for turning embryonic stem cells into insulin-producing pancreatic tissue in what could prove a significant breakthrough in the quest to find new treatments ... > read more New Source Of Islet Cells For Islet Transplantion For Type 1 Diabetes (Oct. 25, 2007) — Islets transplantation is one promising approach to type 1 diabetes treatment, but it is limited by the shortage of islet cells. To address this issue, scientists have successfully shortened the ... > read more Ads by Google Stem Cell Therapy $7.5k — Affordable Stem Cell Treatment Performed by specialist surgeons HealthTravelGuides.com/Stem-Cells we treat diabetes — call (847)982-9988 New pateints are welcome! www.Rdoctors.com Diabetes Treatment — New Stem Cell Therapy for Diabetes Patients. We Can Help You! Medra.com/Diabetes Journal Reference: 1. Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar, Theodore Mazzone. Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Medicine, 2012; 10: 3 DOI: 10.1186/1741-7015-10-3 Search ScienceDaily Number of stories in archives: 120,087 Need to cite this story in your essay, paper, or report? Use one of the following formats: APA MLA BioMed Central (2012, January 9). Stem cell therapy reverses diabetes: Stem cells from cord blood used to re-educate diabetic's own T cells. ScienceDaily. Retrieved June 26, 2012, from http://www.sciencedaily.com /releases/2012/01/120109211827.htm Note: If no author is given, the source is cited instead. Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff. Search Find with keyword(s): Enter a keyword or phrase to search ScienceDaily's archives for related news topics, the latest news stories, reference articles, science videos, images, and books. http://www.sciencedaily.com/releases/2012/01/120109211827.htm 6/26/2012