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Nutrition and Food Science Elucidating Metabolic Effects & Health Benefits of Dietary Components Explore the Complex Relationship Between Nutrition and Metabolism Nutrients and non-essential compounds present in foods interact with a number of metabolic pathways. Decoding these complex interactions is challenging as nutrients may subtly interact with multiple targets. Metabolomics can be essential to investigating the role that dietary components play in health, health maintenance and disease. In fact, understanding the underlying biology of chronic diseases is needed to drive successful disease prevention strategies. In order to identify biomarkers of risk and prevention, and the effects of nutrition on these measures, a systems biology approach using metabolomics has proven to be effective1. Metabolomics can help to answer critical questions. What effect does the nutrient impact? • Identify bioactive components and function (MOA) • Identify biomarkers of consumption • Demonstrate efficacy Client Benefits: What is the composition? • Product equivalence, characterization, and integrity • Assess stability and bioavailability • Insight into energy metabolism and contribution of biomolecules to physiologic pathways How does the dietary component effect markers of disease risk? • Post-prandial metabolic effects • Identify bioactive mechanism of action • Demonstrate efficacy • Propose mechanism of action for functional food How much is needed for the desired effects? • Effect of nutritional intervention on a disease/condition • Determine optimal intake concentrations • Support efficacy claims • Determine influence on markers of disease risk How safe are nutrients at efficacious levels? • Demonstrate safety of bioactive • Support safety claims Metabolon is uniquely suited to explore bioactive components and understand the complex relationship between nutrition and metabolism by using a comprehensive metabolomics approach, employing a broad-survey discovery and focused lipidomics profiling. Metabolon’s scientists can interpret the metabolomic data set in the context of the phenotype and environmental data providing specific insight into the relationship between food components, metabolism and health benefits. Lipomics, a division of Metabolon, with established expertise in lipid metabolism, quantitatively measures and identifies the relationship of nutrients with metabolic outcomes2,3,4. • Prebiotics/probiotics: action and effect • Effects on gut microflora and the role gut microflora play in digestion • Diurnal variations of metabolism TrueVision™ Offering The TrueVision™ Offering is a high-throughput metabolomics survey which is ideal for life science research and development. This offering provides the most extensive coverage of the metabolome. Most any sample type is feasible for study, but typically 500-1000 biochemicals can be identified and measured in human plasma and tissue samples in the TrueVision™ offering. Results are expertly interpreted and presented, in a comprehensive report that is delivered complete with heat map displays, raw data, relevant statistics and literature support. The TrueVision™ expert analysis and report enable an understanding of the global narrative of a biological system and avenues for moving forward. References 1. Sha, W., et al., Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. Faseb J. 24(8): p. 2962-2975. 2. Zeisel, S.H., Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am J Clin Nutr. (2007). 86(3): p. 542-548. 3. Zeisel, S.H., et al., The nutritional phenotype in the age of metabolomics. J Nutr. (2005). 135(7): p. 1613-1616. 4. Rezzi, S., et.al., Nutritional Metabolomics: Applications and Perspectives. J Proteome Research. (2007). 6, 513-525. Biochemical Pathways Map illustrating the extensive coverage of TrueVision™ surveying over 4000 metabolites. TrueVision™ Major Metabolite Coverage by Class Complex Lipid metabolism Lipid metabolism Bile acids Bioactive lipids Cholesterol Fatty acids Inflammatory mediators Lysolipids Microflora metabolism Oxidized lipids (COX, LOX) Amino acid metabolism Amino acid breakdown Amino acid catabolism Sphingosine Sterols Carbohydrate metabolism Cardiolipin Cholesteryl Ester Diacylglycerol Free fatty acid Cofactor and vitamins metabolism Gluconeogenesis Ascorbate metabolism Glucose metabolism CoA metabolism Lysophosphatidylcholine Phosphatidylcholine Phosphatidylethanolamine Phosphatidylserine Energy metabolism Nucleotide metabolism Acylcarnitines Degradation of nucleotides Beta-oxidation Deoxyribonucleotides Creatine metabolism DNA damage Bioactive intermediates & trace amines Glycogen metabolism FAD metabolism Glutathione metabolism Glycosylation pathways Folate metabolism Inflammatory mediators Metabolism of other carbon sources Many other cofactors and vitamins (tocopherol, B12, Biotin) Pentose phosphate pathway NAD/NADP metabolism TCA cycle Microflora metabolism Metabolism of other key sugars (e.g. fructose, galactose) Polyamines/ornithine metabolism Urea cycle Polyol metabolism PLP metabolism Pyruvate metaboloism SAM metabolism (methylation) Sphingomyelin Triacylglycerol FAD metabolism FAD metabolism Glycolysis Modified nucleotides Mitochondrial function Nucleotide Coenzymes (e.g. pantothenate) Purine and pyrimidine de novo synthesis Purine and pyrimidine salvage synthesis Ribose metabolism European Headquarters London, England +44 (0) 20 3 318 5807 Madrid, Spain +34 (0) 609 106 782 © Copyright Metabolon, Inc. 2013 Corporate Headquarters Research Triangle Park, North Carolina +1.919.572.1711 www.metabolon.com [email protected]