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Towards functional effects of polyphenols : modulation of energy
Towards functional effects of polyphenols : modulation of energy

... polyphenol aglycones and are therefore easily eliminated through bile and urine [36-38]. Chronic administration of selected polyphenols could possibly increase the systemic exposure considerably. Flavonols have plasma half lives of ~20h, whereas catechins and anthocyanins are eliminated 5-10 times f ...
Regulation of the phosphotransferase system (PTS)
Regulation of the phosphotransferase system (PTS)

... Corynebacterium glutamicum is a Gram-positive bacterium used in the biotechnological production of amino acids. It co-metabolizes most substrates, such as glucose and sucrose. The uptake and concomitant phosphorylation of those two substrates is mediated by the phosphoenolpyruvate (PEP)-dependent ph ...
Carnitine-Metabolism and Functions
Carnitine-Metabolism and Functions

... TRANSPORT ...
Evidence of separate pathways for lactate uptake and release by the
Evidence of separate pathways for lactate uptake and release by the

... part of an intracellular lactate shuttle, which could account for the simultaneous release and uptake of lactate in well-oxygenated tissue. However, despite this evidence, there have been no studies specifically designed to determine whether lactate efflux from the myocardium that occurs simultaneou ...
Lack of Knowledge on the Use and Benefits of Creatine
Lack of Knowledge on the Use and Benefits of Creatine

... when certain sports require dehydration, for example like wrestling. Furthermore, more ASOS mentions that it is dangerous for someone who is trying to lose weight. This is because, water will be retained, which increases weight, and not decrease it. Plus, an increased water weight will keep the fact ...
Biomarkers in Cardiovascular System Dr. Bibi Kulsoom
Biomarkers in Cardiovascular System Dr. Bibi Kulsoom

... • Tissue location & Isoenzyme: five isoezymes mainly distributed ...
Creatine A Complete Users Guide
Creatine A Complete Users Guide

... USA fined $70,000 for false claims about sports performance product Muscle Marketing USA Limited has been fined $70,000 in the Auckland District Court today for breaching the Fair Trading Act in relation to its sports performance enhancing product ATP Advantage Creatine Serum. In sentencing, Judge E ...
ESTUDIO DE LOS MECANISMOS DE INHIBICIÓN DE LA ACTIVIDAD CARNITINA PALMITOILTRANSFERASA 1
ESTUDIO DE LOS MECANISMOS DE INHIBICIÓN DE LA ACTIVIDAD CARNITINA PALMITOILTRANSFERASA 1

... The enzyme carnitine palmitoyltransferase (CPT)1 I catalyzes the conversion of long chain fatty acyl-CoAs to acylcarnitines, which is the first step in the transport of fatty acyl-CoA groups from the cytosol to mitochondria where they undergo ␤-oxidation. This reaction is inhibited by malonyl-CoA, a ...
Intermediary metabolism of fructose3
Intermediary metabolism of fructose3

... 70% of their energy-intake feeding of fructose-containing in the activity ...
rapid acting insulin analogues - The Association of Physicians of India
rapid acting insulin analogues - The Association of Physicians of India

... convenience, reduced risk of hypoglycemia and, in some instances, less weight gain. Combined, these elements may increase a patient’s adherence to treatment, potentially increasing the level of glycemic control and improving the prognosis in patients with diabetes mellitus. Rapid-acting insulin anal ...
Lactic acidosis - Medical School
Lactic acidosis - Medical School

... concentration of pyruvate; the [NADH]/[NAD] ratio, otherwise referred to as the redox (reductionloxidation) state; and the intracellular hydrogen ion concentration. Pyruvate concentration. Assuming no change in the other two determinants, an increment in pyruvate concentration should lead to a propo ...
Regulation of Exogenous and Endogenous Glucose Metabolism by
Regulation of Exogenous and Endogenous Glucose Metabolism by

... Myocardial substrate use is tightly controlled not only by the availability of substrate and oxygen, but also by the workload imposed on the heart and the hormonal environment. While fatty acid oxidation is the major energy source for the heart under normal conditions in vivo, changes in the above f ...
inclusion of a glycogen regulation mathematical model into a
inclusion of a glycogen regulation mathematical model into a

... A dissertation submitted to the faculty of the University of North Carolina at Chapel Hill in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Mathematics. ...
Free radical scavenging and antioxidant effects of lactate ion: an in
Free radical scavenging and antioxidant effects of lactate ion: an in

... tion and lipid peroxidation, as evaluated by malondialdehyde (MDA), during a progressive incremental exercise. However, Anbar and Neta (2), in tests of the scavenging activity of various and numerous agents toward the hydroxyl radical (䡠OH), noted that the lactate ion acted as a moderate 䡠OH scaveng ...
Lecture 33 - University of Arizona
Lecture 33 - University of Arizona

... elevated rates of glycogen synthesis. ...
Endocytosis, Recycling, and Regulated Exocytosis of Glucose
Endocytosis, Recycling, and Regulated Exocytosis of Glucose

... in the fission of vesicles from membranes, is necessary for CME and has also been implicated in caveolin-1-, IL-2Rβ-, and flotillindependent endocytotic processes.15 GLUT4, the major carrier of glucose into muscle and fat cells, is a recycling protein that is continuously removed from and recycled b ...
Presentation part1-201210091211
Presentation part1-201210091211

... Under normal physiological conditions, the primary site of carnitine production is in the liver. During lactation, the production of carnitine in the mammary gland increases, apparently at the expense of production in the mother's liver, which is also accompanied by reduced hepatic enzymatic and tra ...
Glutamine metabolism and its effects on immune response
Glutamine metabolism and its effects on immune response

... mainly from the muscle and lung to the liver, as glutamine, alanine, and aspartate. The breakdown of glutamine releases NH3 that through mitochondrial enzymes enters the urea cycle as a substrate. The urea cycle consumes two molecules of ammonia and one molecule of carbon dioxide, creates one molecu ...
principles of metabolic regulation: glucose and glycogen
principles of metabolic regulation: glucose and glycogen

... residues with about 2,000 nonreducing ends. Twenty to 40 of these particles cluster together to form -rosettes, easily seen with the microscope in tissue samples from well-fed animals (Fig. 15–2) but essentially absent after a 24-hour fast. The glycogen in muscle is there to provide a quick source ...
Ketone Body Metabolism Preserves Hepatic Function during
Ketone Body Metabolism Preserves Hepatic Function during

... are synthesized in liver from acetyl-CoA derived primarily from fatty acid oxidation and are transported to extrahepatic tissues for terminal oxidation during physiological states characterized by limited carbohydrate and surplus fatty acid availability [reviewed in (4,5); (Figs. 1.1A-B)]. Ketone bo ...
insulin therapy for children and adolescents with type 1 diabetes
insulin therapy for children and adolescents with type 1 diabetes

... History of insulin treatment1  Diabetes recognized as a distinct medical condition for at least 3500 yrs.  Before the discovery of insulin, the only way to control diabetes was a diet low in CHO and high in fat and protein.  In 1889, Minkowski removed the pancreas from a healthy dogs → developed ...
Creatine supplementation with specific view to exercise/sports
Creatine supplementation with specific view to exercise/sports

... Although creatine supplementation has been shown to be more effective on predominantly anaerobic intermittent exercise, there is some evidence of its positive effects on endurance activities. Branch [28] highlights that endurance activities lasting more than 150s rely on oxidative phosphorylation as ...
Ch31-Gluconeogenesis and Maintenance of Blood Glucose Levels
Ch31-Gluconeogenesis and Maintenance of Blood Glucose Levels

... Some tissues of the body, such as the brain and red blood cells, cannot synthesize glucose on their own, yet depend on glucose for energy. On a long-term basis, most tissues also require glucose for other functions such as the synthesis of the ribose moiety of nucleotides or the carbohydrate portion ...
Ch23-Oxidation of Fatty Acids and Ketone Bodies
Ch23-Oxidation of Fatty Acids and Ketone Bodies

... Fatty acids are a major fuel for humans and supply our energy needs between meals and during periods of increased demand, such as exercise. During overnight fasting, fatty acids become the major fuel for cardiac muscle, skeletal muscle, and liver. The liver converts fatty acids to ketone bodies (ace ...
The network of calcium regulation in muscle
The network of calcium regulation in muscle

... regulation of actomyosin activity by Ca2+ (Weber, 1959) through its interaction with troponin (Ebashi, 1963; Ebashi et al., 1999). In the intervening years the messenger role of Ca2+ has been demonstrated in virtually all living cells and all cellular compartments, in processes as diverse as cell di ...
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Myokine

A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions. They have autocrine, paracrine and/or endocrine effects; their systemic effects occur at picomolar concentrations.Receptors for myokines are found on muscle, fat, liver, pancreas, bone, heart, immune, and brain cells. The location of these receptors explain the fact that myokines have multiple functions. Foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation. They also participate in tissue regeneration and repair, maintenance of healthy bodily functioning, immunomodulation; and cell signaling, expression and differentiation.
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