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Transcript
Regulation of ferritin genes and protein by Frank M. Torti, and Suzy V. Torti Blood Volume 99(10):3505-3516 May 15, 2002 ©2002 by American Society of Hematology Foundations of ferritin biology: IRE/IRP and iron-mediated regulation.Note model of 5′ IRE repression of ferritin translation in low-iron conditions is similar to mechanism of iron-mediated regulation of erythroid ALA synthase (e-ALAS) gene. Frank M. Torti, and Suzy V. Torti Blood 2002;99:3505-3516 ©2002 by American Society of Hematology Mouse and human ferritin H genes.In the murine gene, regulatory regions reside between 4 kb and 5 kb distal to the transcriptional start site; in the human gene, regulatory regions are just 5′ of the TATA box. Frank M. Torti, and Suzy V. Torti Blood 2002;99:3505-3516 ©2002 by American Society of Hematology Complexities in ferritin regulation.The schematic highlights temporal changes in ferritin transcription and translation in response to oxidants and cytokines in cultured cells. Frank M. Torti, and Suzy V. Torti Blood 2002;99:3505-3516 ©2002 by American Society of Hematology
