Download Biological Membranes, Drug Targets and Absorption Barriers

Biological Membranes, Drug Targets and Absorption Barriers
Provider: Københavns Universitet/Copenhagen University
Activity no.: 3146-14-00-00
Enrollment deadline: 01-09-2014
Date and time
14.11.2014, at: 09:00 - 21.11.2014, at: 16:00
Regular seats
16
Course fee
7.800,00 kr.
Lectureres
Birger Brodin
Harald S. Hansen
ECTS credits
5,00
Course Secretary
Janne Kjærulf
E-mail address: [email protected]
Enrollment handling PhD administration
E-mail address: [email protected]
Aim and content
Learning objectives
The course objectives are to provide a comprehensive overview of the biochemistry and barrier functions of
biological membranes, as well as an insight in the structure and function of biological transport proteins.
Pharmacological and pharmaceutical aspects of biological membrane structure and function will be emphasised
A student who has met the objectives of the course will be able to:
a. The student will have gained an in-depth understanding of the structure and function of membrane lipids and
transport proteins, and their role as drug targets and interaction with drug delivery systems and active
pharmaceutical ingredients (API's).
b. The student will be able to discuss and perform a critical judgment of scientific literature and presentations
within the field.
c. The student will be able to relate her/his own research to the overall paradigms within the field, and will have
gained some presentation/discussion skills in presentation of her/his own results in oral form.
(Instructions on describing learning objectives: Please describe the students’ learning objectives in terms of
knowledge, skills and/or compentencies. Depending on the individual course curriculum, the distribution
between these three learning objectives may vary between courses and thus not all three may be present.
Describe the obtained knowledge with words such as ability to identify, define, describe, have insight,
understand, analyse, conclude on etc. the scientific topic or the curriculum of the course.
Describe the obtained skills gained from the course with words such as ability to explain, apply, demonstrate,
analyse, argue, plan, process, relate, review, compare, use, systemize, diagnose etc.
Describe obtained competencies with words such as ability to assess, appraise, reflect on, discuss, evaluate,
predict, theorise, generalise, put into perspective, develop etc.
Please state 3-5 learning objectives.)
Content
Studies on the biochemistry, biophysics and the barrier function of biological membranes are in rapid progress.
An understanding of the structural and dynamic functions of the membranes (e.g. plasma membranes and
intercellular membranes in the stratum corneum) may add to a more rational design of drug substances with
improved permeation characteristics or specific membrane effects. Membrane transport proteins are important
both as pharmacological targets and as potential drug delivery pathways. Membrane receptors are important
drug targets, and may also be of importance as drug uptake pathways. The course will deal with biological
membranes and their embedded transport and receptor proteins from a pharmacological and pharmaceutical
point of view. The course will cover various aspects of the following topics;
-
Structure and function of biological membranes
Physiological structures in the plasma membrane
Transport and receptor proteins in the plasma membrane
Drug substances acting on biological membranes/transporters
Structure and function of barrier tissues
Strategies to improve transport of drugs across biological membranes and barrier tissues
Membrane lipids as precursors of bioactive molecules
Participants
The course is aimed at PhD-students within the life sciences, performing research related to biological
membranes/transport proteins/receptor proteins, and with an interest in pharmacology and/or pharmaceutics.
The students should have a Master degree within the natural sciences or an equivalent curriculum.
Language
The course language is English
Please note that all courses have to be provided in English if required by non-Danish participants.
Form
The course will contain lectures by internationally recognised researchers within their respective fields, oral
presentations, essay writing and group discussions.
Course director
Harald S. Hansen, PhD. Professor, Department of Drug Design and Pharmacology, Pharma-School, The Faculty
of Health and Medical Sciences, University of Copenhagen.
Email; [email protected]
Birger Brodin, PhD. Associate Professor, Department of Pharmacy, Pharma-School, The Faculty of Health and
Medical Sciences, University of Copenhagen.
Email; [email protected]
Teachers
See attached course programme
Course secretary
Janne Steen Kjærulff
Email; [email protected]
Dates
November 14-21 , 2014
Course location
Pharma School