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Agard Protein Folding:
Discussion Paper 16
Paper 16
Eriksson AE, Baase WA, Zhang X-J, Heinz DW, Blaber M, Baldwin
EP, Matthews BW. 1992. Response of a protein structure to
cavity-creating mutations and its relation to the hydrophobic
effect. Science 255:178-83
Pauling
1) Introduction: focus on background to these experiments
2) Table 3: how were Vol and Area calculated
Franklin
1) Table 1: definition and significance of Xtal terms
2) Figure 2A, 2B, also interpretation of double mutant
Crick
1) Fig 1
2) Table 2: how measured stability, assumptions involved, etc
3) Conclusions: comparison to hydrophobicity based on transfer free
energies,
importance of X-ray studies