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Monoclonal Antibodies Treatment for
Various Diseases
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Monoclonal antibodies are widely used for the treatment of various types of
cancers. They are mainly involved in immunotherapy. Clinical study is conducting
on various monoclonal antibodies and other related proteins. Many of these
antibodies are being approved for diseases like inflammation and cancer. A lot of
researches are conducting to create monoclonal antibodies that are able to cure
various diseases.
Some of the diseases cured by these antibodies include:
• Various types of cancers
• Rheumatoid arthritis
• Tumors
• Multiple sclerosis
• Lymphoma
What Is Antibody Screening and Phage Display?
Antibody screening is the process used for identifying productive cell lines. This
will help to minimize the cost of downstream processing steps. Early identification
of productive cell lines will enhance the success in scale up activities. Phage
display screening process is mainly used for the identifying high affinity antibodies
or peptides. Following are some of the important uses of phage display:
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• Used for screening protein interaction
• Help to analyze the mechanism or functioning of a protein
• One of the important techniques used in protein engineering.
• Considered as a tool in medicine or drug discovery
• Help to determine tumor antigens
Function of Antibodies
The immune system of our body is capable of generating certain antibodies. These
antibodies will attach foreign substances called antigens and neutralize or destroy
them. If our body is exposed to a bacteria or virus, then it will get rid of infection
by producing antibodies. Antibodies are considered as the natural defensive
substances. They are generally produced by the B cell of the immune system. They
help in the recognition of foreign antibodies and then stimulate immune response
to them. Antigen presenting cells are involved in adaptive immune response.
Important Medications Using Monoclonal Antibodies
Monoclonal antibodies can be used in different forms of therapy. They are used for
blocking certain cell receptors and also for destroying malignant tumor cells. There
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are also variations within the treatment procedures. These types of treatment
mainly include medications like Bexxar, Herceptin and Rituxan. Bexxar contains a
radioactive iodine molecule and so it does not have a naked form. This medicine
has some negative effects like fever, shakes or chills. Medication involving
Herceptin is specific for destroying cancer cells in the breast. Treatment procedure
that involves Rituxan is very much effective in treating various types of
lymphomas, especially Non-Hodgkin's lymphoma.
Various Aspects of Monoclonal Antibody Therapy
Monoclonal antibody therapy is quite effective and safe for certain patients. This
treatment is not suitable for routine clinical setting because it have to be tailored to
each individual patient. This technology is effective in creating antibodies against
certain antigens present on the tumor surfaces. These are laboratory produced
substances which are able to produce anti-tumor effects. They have been used with
radioactive particles or toxins for killing cells. They are mainly used for binding
molecule called tumor necrosis factor (TNF). TNF is the main cause of
inflammation and rheumatoid arthritis. Monoclonal proteins called Remicade and
Humira are TNF inhibitors.
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