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Rabbit Anti-Human NOG Polyclonal Antibody
Catalog No.
HS-PP-0203
Size
100 μl
Description
Rabbit Polyclonal to NOG (Gene ID 9241)
Physical State
Liquid
Antibody Concentration 1 mg/ml
Antibody form
Affinity isolated antibody
Tested applications
WB,Indirect ELISA
Species reactivity
Human
Antibody Purity
Protein A purified
Suggested Dilution
1:500- 1:1000 for WB
Range
1:5,000- 1:100,000 for ELISA
Storage Instructions
Store at 2-8°C for up to 6 months and
-20°C for long
term storage in small aliquots to prevent freeze-thaw
cycles.
Immunogen
This anti-NOG antibody is generated from rabbits
immunized with a KLH conjugated synthetic peptide.
Background Information Noggin is a secreted polypeptide which binds and
inactivates
members
of
the
transforming
growth
factor-beta (TGF-beta) superfamily signaling proteins,
such as bone morphogenetic protein-4 (BMP4). By diffusing
through extracellular matrices more efficiently than
members of the TGF-beta superfamily, it may have a
principal role in creating morphogenic gradients. Noggin
appears
to
have
pleiotropic
effect,
both
early
in
development as well as in later stages. The results of the
mouse knockout of the ortholog suggest that noggin is
involved in numerous developmental processes, such as
neural tube fusion and joint formation. Recently, several
dominant human NOG mutations in unrelated families with
proximal symphalangism (SYM1) and multiple synostoses
河北翰林生物科技有限公司，石家庄市高新区长江大道 238 号，宏昌科技园
电话：0311-67590303, 传真：0311-67590303
www.hanlinbiotechnology.com
Sunny Biotechnology Co., 248 Deming Place, Westmont, IL 60559, USA
Phone: 630-664-3691, Fax: 630-689-0020
www.sunnybiotechnology.com
Rabbit Anti-Human NOG Polyclonal Antibody
Catalog No.
HS-PP-0203
Size
100 μl
syndrome (SYNS1) were identified; both SYM1 and SYNS1
have multiple joint fusion as their principal feature, and
map to the same region (17q22) as this gene. All of these
mutations altered evolutionarily conserved amino acid
residues. The amino acid sequence of this human gene is
highly homologous to that of Xenopus, rat and mouse.
Note
For in vitro research use only, not for diagnostic or
therapeutic use. This product is not a medical device.
Whole cell lysates of Hela (lane 1:30μg) were subjected to SDS PAGE followed by
western blot with HS-PP-0203 antibody at dilution of 1:400.
Predicted molecular weight: 26 kDa.
河北翰林生物科技有限公司，石家庄市高新区长江大道 238 号，宏昌科技园
电话：0311-67590303, 传真：0311-67590303
www.hanlinbiotechnology.com
Sunny Biotechnology Co., 248 Deming Place, Westmont, IL 60559, USA
Phone: 630-664-3691, Fax: 630-689-0020
www.sunnybiotechnology.com