Download ACTH_Instruction

Rabbit Anti-Human ACTH Polyclonal Antibody
Catalog No.
HS-PP-0435
Size
100 μl
Description
Rabbit Polyclonal to ACTH (Gene ID 5443)
Physical State
Liquid
Antibody Concentration 1 mg/ml
Antibody form
Affinity isolated antibody
Tested applications
WB,Indirect ELISA
Species reactivity
Human
Antibody Purity
Protein A purified
Suggested Dilution
1:500- 1:1000 for WB
Range
1:5,000- 1:100,000 for ELISA
Storage Instructions
Store at 2-8°C for up to 6 months and
-20°C for long
term storage in small aliquots to prevent freeze-thaw
cycles.
Immunogen
This anti-ACTH antibody is generated from rabbits
immunized with a KLH conjugated synthetic peptide.
Background Information This gene encodes a polypeptide hormone precursor that
undergoes extensive, tissue-specific, post-translational
processing via cleavage by subtilisin-like enzymes known as
prohormone
convertases.
There
are
eight
potential
cleavage sites within the polypeptide precursor and,
depending on tissue type and the available convertases,
processing may yield as many as ten biologically active
peptides involved in diverse cellular functions. The encoded
protein is synthesized mainly in corticotroph cells of the
anterior pituitary where four cleavage sites are used;
adrenocorticotrophin, essential for normal steroidogenesis
and the maintenance of normal adrenal weight, and
lipotropin beta are the major end products. In other
tissues,
including
the
hypothalamus,
placenta,
and
epithelium, all cleavage sites may be used, giving rise to
河北翰林生物科技有限公司，石家庄市高新区长江大道 238 号，宏昌科技园
电话：0311-67590303, 传真：0311-67590303
www.hanlinbiotechnology.com
Sunny Biotechnology Co., 248 Deming Place, Westmont, IL 60559, USA
Phone: 630-664-3691, Fax: 630-689-0020
www.sunnybiotechnology.com
Rabbit Anti-Human ACTH Polyclonal Antibody
Catalog No.
HS-PP-0435
Size
100 μl
peptides with roles in pain and energy homeostasis,
melanocyte stimulation, and immune modulation. These
include several distinct melanotropins, lipotropins, and
endorphins
that
are
adrenocorticotrophin
and
contained
within
beta-lipotropin
the
peptides.
Mutations in this gene have been associated with early onset
obesity, adrenal insufficiency, and red hair pigmentation.
Alternatively spliced transcript variants encoding the same
protein have been described.
Note
For in vitro research use only, not for diagnostic or
therapeutic use. This product is not a medical device.
Whole cell lysates of human brain (lane 1:40μg) , Hela (lane 2:40μg) and A549 (lane 3：
40μg) were subjected to SDS PAGE followed by western blot with HS-PP-0435
antibody at dilution of 1:400.
Predicted molecular weight: 29.4kDa.
河北翰林生物科技有限公司，石家庄市高新区长江大道 238 号，宏昌科技园
电话：0311-67590303, 传真：0311-67590303
www.hanlinbiotechnology.com
Sunny Biotechnology Co., 248 Deming Place, Westmont, IL 60559, USA
Phone: 630-664-3691, Fax: 630-689-0020
www.sunnybiotechnology.com