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Rabbit Anti-Human ACTH Polyclonal Antibody Catalog No. HS-PP-0435 Size 100 μl Description Rabbit Polyclonal to ACTH (Gene ID 5443) Physical State Liquid Antibody Concentration 1 mg/ml Antibody form Affinity isolated antibody Tested applications WB,Indirect ELISA Species reactivity Human Antibody Purity Protein A purified Suggested Dilution 1:500- 1:1000 for WB Range 1:5,000- 1:100,000 for ELISA Storage Instructions Store at 2-8°C for up to 6 months and -20°C for long term storage in small aliquots to prevent freeze-thaw cycles. Immunogen This anti-ACTH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide. Background Information This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to 河北翰林生物科技有限公司,石家庄市高新区长江大道 238 号,宏昌科技园 电话:0311-67590303, 传真:0311-67590303 www.hanlinbiotechnology.com Sunny Biotechnology Co., 248 Deming Place, Westmont, IL 60559, USA Phone: 630-664-3691, Fax: 630-689-0020 www.sunnybiotechnology.com Rabbit Anti-Human ACTH Polyclonal Antibody Catalog No. HS-PP-0435 Size 100 μl peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are adrenocorticotrophin and contained within beta-lipotropin the peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. Note For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device. Whole cell lysates of human brain (lane 1:40μg) , Hela (lane 2:40μg) and A549 (lane 3: 40μg) were subjected to SDS PAGE followed by western blot with HS-PP-0435 antibody at dilution of 1:400. Predicted molecular weight: 29.4kDa. 河北翰林生物科技有限公司,石家庄市高新区长江大道 238 号,宏昌科技园 电话:0311-67590303, 传真:0311-67590303 www.hanlinbiotechnology.com Sunny Biotechnology Co., 248 Deming Place, Westmont, IL 60559, USA Phone: 630-664-3691, Fax: 630-689-0020 www.sunnybiotechnology.com