Download RBC seminar Transcriptional repression of DNA repair genes is a

RBC seminar Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence Dr. David Bernard Senescence Escape Mechanisms lab,
Cancer Research Center of Lyon, UMR INSERM France
日時：10 月 24 日(月) 15 時 00 分から
場所：放射線生物研究センター、１階セミナー室 Senescence response is (i) activated by numerous cellular stresses such as
replicative exhaustion, radiation, genotoxic, oncogenic signals, inflammation,
metabolic stress as well as oxidative stress, (ii) it is characterized by a stable
proliferation arrest, and (iii) it results in the acquisition of a specific secretome.
Timely regulated senescence is thought to be beneficial as it exerts tumor
suppressive activity, it contributes to wound healing and even to embryonic
development. By contrast, chronic senescence such as during normal or
premature aging is deleterious as it favors most, if not all, aging related
diseases. In the aging context, restricted proliferation of senescent cells limits
the organ renewal capabilities and the senescent secretome to the
neighborhood alters tissue architecture and functions, both are thought to
favor age-related pathologies. We have recently observed, in the transcriptome
program of senescent cells (oncogene-induced senescence, genotoxic stress
induced senescence or oxidative stress induced senescence) in several type
of cells (epithelial cells as well as fibroblasts) a drastic expression decrease of
tens of DNA repair genes at the mRNA levels. This supports that loss of DNA
repair gene expression is a hallmark of senescent cells. Strikingly, the sole
knockdown of a single DNA repair gene, in most of the cases, results in a
premature senescence supporting a causal role of the loss of DNA repair
capacity in mediating most types of cellular senescence. During my
presentation I will detail these results and discuss these results in the context
of the known literature, in particular the well-known increase of DNA damages
in senescent cells.
This seminar will be held on Oct. 24th 15:00~, at 1F Seminar Rm, Radiation Biology Center, Kyoto Univ. 連絡先：放射線生物研究センター、放射線システム研究部門 Kanji Furuya (075-753-7555, [email protected])