Download ATP Synthase Dynamic

Mitochondria – ATP Synthase
John Walker – Martin Montgomery
In your body the electric motor enzyme ATP Synthase driven by
protons – not electrons – catalyses the reaction: ADP + P → ATP
A protons neutralise negatively charged
groups on the stator causing it to turn
www.bioc.aecom.yu.edu
A rotating central spindle opens
and closes the cavity gaps
allowing ADP and P in and ATP out
http://en.wikipedia.org/wiki/ATP_synthase
Meccano Clockwork Motor
Hornby Metropolitan Londom
Subway Engine
ATP synthase (EC 3.6.3.14) is an important enzyme that provides
energy for the cell to use through the synthesis of adenosine
triphosphate (ATP). ATP is the most commonly used "energy
currency" of cells from most organisms. It is formed from adenosine
diphosphate (ADP) and inorganic phosphate (Pi), and needs
energy.
The overall reaction sequence is: ATP synthase + ADP + Pi → ATP
Synthase + ATP
Energy is often released in the form of protium or H+, moving down
an electrochemical gradient, such as from the lumen into the
stroma of chloroplasts or from the inter-membrane space into the
matrix in mitochondria.
rotating
spindle opens
and closes
the cavities
ADP + P
enter
A protons neutralise negatively
charged groups on the stator
causing it to turn
ATP ejected
An electric motor
driven by protons
in water !
ADP and P enter
the cavities and
combine to form
ATP
ATP ejected
A protons neutralise
negatively charged groups
on the stator causing it to
turn – this is a real electric
motor – driven by protons
– NB in aqueous media!!!!
Central rotating
spindle opens and
closes the cavities to
allow ADP to enter
and ATP to escape
Balmoos and
Dimroth
This is a real electric motor – driven by
protons (not electrons)
– NB in water !!!!
Paul Boyer and John Walker
ATP ejected
ADP + Pi
enter cavity
rotating spindle
opens and closes the
cavities
Protons neutralise –vely charged moiety on rotor
causing rotor to rotate 30o
ATP
Synthase
Paul Boyer
John Walker