Download syllabus - Wofford

Tentative Class Schedule
Biology 433 - Advanced Topics in Cell Biology
Spring, 2007
Section I – Course Introduction – Amino Acids, Peptides, Proteins – Enzymes
In this section, you will need to learn the structures of the amino acids. It isn’t so difficult,
because you really only need to remember the R groups. Amino acid structures are important for
your understanding protein structure and function. We will emphasize enzymatic mechanisms to
exemplify the importance of structure to function. Then, we will consider some of the current
applications of enzymes.
Week of
2/5
2/9
2/12
Topic/Activity
Course Introduction
Amino Acids
Amino Acid Quiz
(1-28; 60-70)
75 - 89
(Protein Structure & Function )
157 - 174
(116 - 153; 174 - 187)
(190 - 224); 224 - 233
Enzymes – – Action / Regulation
Enzymes – Clinical Applications
2/19
*Vitamins & Coenzymes
Overview & Review of Metabolism
2/23
Reading Assignment
TBA
481-488
Exam I
Section 2—Metabolism: Carbohydrates
We will begin each of the topics with a brief review. You will need to learn the structures of the
major coenzymes and the structures of glycolytic and Citric Acid Cycle intermediates for a
foundation. We will be emphasizing the regulation and coordination of carbohydrate
metabolism.
Week of
2/26
3/2
Topic/Activity
Glycogen Metabolism
Glycolysis
Coenzyme Quiz
Reading Assignment
560-570
521-543
3/5
543-549
571-591
3/9
Glycolysis/Gluconeogenesis
Regulation of Glucose Metabolism
Glycolysis Quiz
601-623
690-722
3/16
Citric Acid Cycle
Electron Transport & Oxidative
Phosphorylation
Citric Acid Quiz
Pentose Phosphate
Applications
549-555
3/12
3/19
3/23
Exam II
Section 3—Metabolism: Lipids
We didn’t have much time to consider lipid metabolism in B214, but we will be able to
concentrate on them in this course. You will need to know the structures of several major lipid
compounds. We will emphasize the effects of fat and cholesterol metabolism on health.
Week of
3/26
Topic/Activity
Reading Assignment
Digestion/Processing of Lipids
Metabolism of Fatty Acids
631-637
637-652
4/9
Complex Lipids
Cholesterol & Other Sterols
787-815
816-829
4/16
821-827
821-827
4/20
Lipoproteins
Atherogenesis
Lipid Quiz
4/23
Exam III
3/30
Section 4—Metabolism: Proteins & Nucleic Acids
Nitrogen is an important constituent of both proteins and nucleic acids. In this module we will
look at how nonessential amino acids are synthesized, how amino acids are degraded and how
nitrogen wastes are eliminated. Structures for the intermediates of the Urea Cycle will need to
be learned. Time permitting, we shall consider briefly the metabolism of pyrimidines and
purines.
Week of
Topic/Activity
Reading Assignment
4/25
Proteins: Digestion/Processing
Endogenous Degradation
4/30
Amino Acid catabolism
656-686
5/7
Amino Acid anabolism
Urea Cycle
Applications
841-854
841-854
5/15
Final Examination