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ProSci Inc ProSci Inc Cathelicidin Antibody CATALOG NUMBER: 4429 Availability: In stock $0.00 Western blot analysis of Cathelicidin in Human spleen tissue lysate with Cathelicidin antibody at 1 ug/mL. Immunofluorescence of Cathelicidin in Human Spleen cells with Cathelicidin antibody at 20 ug/mL. Immunohistochemistry of Cathelicidin in human spleen tissue with Cathelicidin antibody at 5 ug/ml. Immunohistochemistry of Catheli-cidin in human spleen tissue with Cathelicidin antibody at 5 ug/mL. Specifications Properties Additional Info Background Specifications SPECIES Human REACTIVITY: TESTED ELISA, IF, IHC-P, WB APPLICATIONS: Cathelicidin antibody can be used for detection of Cathelicidin by Western blot at APPLICATIONS: 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL. USER NOTE: Optimal dilutions for each application to be determined by the researcher. POSITIVE CONTROL: 1) Cat. No. 1306 - Human Spleen Tissue Lysate 2) Cat. No. 10-901 - Human Spleen Tissue Slide PREDICTED Predicted: 19 kDa MOLECULAR Observed: 18 kDa WEIGHT: IMMUNOGEN: Cathelicidin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Cathelicidin. The immunogen is located within amino acids 50 - 100 of Cathelicidin. HOST SPECIES: Rabbit Properties PURIFICATION: Cathelicidin Antibody is affinity chromatography purified via peptide column. PHYSICAL STATE: Liquid BUFFER: Cathelicidin Antibody is supplied in PBS containing 0.02% sodium azide. CONCENTRATION: 1 mg/mL Cathelicidin antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Polyclonal STORAGE CONDITIONS: CLONALITY: ISOTYPE: IgG CONJUGATE: Unconjugated Additional Info ALTERNATE Cathelicidin Antibody: LL37, CAP18, CRAMP, HSD26, CAP-18, FALL39, FALL-39, NAMES: Cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein ACCESSION NP_004336 NO.: PROTEIN GI 39753970 NO.: OFFICIAL SYMBOL: CAMP GENE ID: 820 Background Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules BACKGROUND: is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response. 1) Zaiou M and Gallo RL. Cathelicidins, essential gene-encoded mammalian REFERENCES: antibiotics. J. Mol. Med. 2002; 80:549-61. 2) Agerberth B, Gunne H, Odeberg J, et al. FALL-39, a Putative Human Peptide Antibiotic, is Cysteine-Free and Expressed in Bone Marrow and Testis. Proc. Natl. Acad. Sci. USA 1995; 92:195-9. 3) Nizet V, Ohtake T, Lauthe X, et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414:454-7. 4) Koczulla R, von Degenfeld G, Kupatt C, et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 2003; 111:1665-72. For Research Use Only June 19, 2017