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Transcript
TBL Module: Blood and Lymphoid Tissue Learning Objectives • Describe the microscopic appearance of erythrocytes, their principal function, the importance of erythrocyte cell-surface antigens, and how different kinds of anemia affect erythrocyte size and shape. • Describe the microscopic appearance of the different white blood cells, their relative proportions, how they function, and the unique cellular features that characterize each type, e.g., specific granules. • Describe the microscopic appearance of platelets and be able to explain their role in thrombus formation. • List the developmental stages of erythrocytes, granulocytes, and platelets, and be able to describe the morphological changes that occur during development. • Explain the distinction between humoral and cell-mediated immune responses and describe how the different lymphocyte subclasses interact with antigen to elicit these responses. • Explain how MHC molecules are involved in lymphocyte activation and be able to describe the functions of macrophages and other antigen-presenting cells. • Describe the histological organization of lymphatic nodules, lymph nodes, spleen, and thymus, their respective roles in the immune response, and be able to distinguish these lymphoid tissues in the microscope. • Describe lymphocyte recirculation and know which lymphoid tissues have afferent lymphatic vessels. Advance Assignment Prior to coming to class, you must read the following: 1. Chapters 10 and 14 in Ross and Pawlina, 7th ed. 2. The class notes for “Peripheral Blood and Myeloid Tissue” and “The Immune System”. Be prepared to take a 10-question, multiple-choice Readiness Assurance Test (RAT) based on the material in the class notes. However, be sure also to read the book chapters to enhance your general understanding of the material and to provide a source of relevant diagrams, tables, and micrographs, which you should consult when studying the class notes.