Download Biology II, Genetics - Southwest Allen County Schools

Southwest Allen County Schools
Science Curriculum 2011-2017
Human Genetics UNIT 1
Desired Results
What should students know and be able to do? (Include state standards and SACS expectations.)
The student will understand the basic foundations of biology that the study of Human Genetics is based
upon.
1.1
Explain the workings of genes, chromosomes, mutations and inherited diseases.
1.2
Distinguish between genotype and phenotype.
1.3
Explain mode of inheritance using the concepts of dominance and recessiveness.
1.4
1.5
Explain the effect of environmental factors, single gene disorders, mutant genes, multifactoral traits and
ecogenetics on gene expression.
Understand the basic structure and function of cells.
1.6
Distinguish between prokaryotic, archaea and eukaryotic cells.
1.7
Understand the basic structure and function of organelles.
1.8
Identify the correlation between malfunctioning cells and organelles with genetic disorders.
1.9
1.10
Explain the functions of the cell cycle, mitosis and apoptosis and apply the effect of their disruption to
disorders.
Compare and contrast the anatomy of the reproductive systems of males and females.
1.11
Explain the process of meiosis including the effects of crossing over and independent assortment.
1.12
Discuss the development of the human embryo from conception to the third month of development.
1.13
Explain the correlation between proper development and birth defects during the critical period
pertaining to malfunctioning genes and environmental factors.
The student will understand the mechanics of how traits are transmitted from parent to offspring.
2.1
Explain the two basic laws of inheritance- segregation and independent assortment.
2.2
Understand basic terminology relating to Mendelian genetics.
2.3
Understand what is shown by a pedigree and be able to construct one from information provided in a
family history.
Calculate risk of inheritance of a gene using the product rule.
2.4
2.5
Give examples of situations in which gene expression appears to alter Mendelian ratios.
2.6
Give examples of situations in which Mendel’s laws do not apply to human inheritance.
2.7
Explain how sex is determined at the chromosomal, gonadal, phenotypic and gender identity levels.
2.8
Compare and contrast sex-limited traits with sex-influenced genes.
2.9
Explain and site examples of multifactoral and polygenetic traits.
Acceptable Evidence
What assessments and products let us know if students have acquired the Desired Results?
Required Acceptable Evidence:
Class discussions over:
Gregor Mendel
Law of Independent Assortment
Law of Segregation
Thomas Hunt Morgan
Sex Linked Traits
The Chromosomal Theory of Inheritance
Mitosis
Meiosis
Completion of case studies, study guides and review questions
Tests and quizzes over material covered in each unit
Other Acceptable Evidence:
Research paper and oral presentation of a Human Genetic disorder
Notebook of current discoveries and developments obtained through newspapers, magazines and the
Internet.
Completion of various supplemental computer programs.
Small group presentations
Class participation
Field trip to Genetics lab
Content
What subject matter will be used to help students achieve the Desired Results?
• Explain the workings of genes, chromosomes, mutations and inherited diseases.
• Distinguish between genotype and phenotype.
• Explain mode of inheritance using the concepts of dominance and recessiveness.
• Explain the effect of environmental factors, single gene disorders, mutant genes, multifactoral traits
and ecogenetics on gene expression.
• Understand the basic structure and function of cells.
• Distinguish between prokaryotic, archaea and eukaryotic cells.
• Understand the basic structure and function of organelles.
• Identify the correlation between malfunctioning cells and organelles with genetic disorders.
• Explain the functions of the cell cycle, mitosis and apoptosis and apply the effect of their disruption
to disorders.
• Compare and contrast the anatomy of the reproductive systems of males and females.
• Explain the process of meiosis including the effects of crossing over and independent assortment.
• Discuss the development of the human embryo from conception to the third month of development.
• Explain the correlation between proper development and birth defects during the critical period
pertaining to malfunctioning genes and environmental factors.
• Explain the two basic laws of inheritance- segregation and independent assortment.
• Understand basic terminology relating to Mendelian genetics.
• Understand what is shown by a pedigree and be able to construct one from information provided in
a family history.
• Calculate risk of inheritance of a gene using the product rule.
• Give examples of situations in which gene expression appears to alter Mendelian ratios.
• Give examples of situations in which Mendel’s laws do not apply to human inheritance.
• Explain how sex is determined at the chromosomal, gonadal, phenotypic and gender identity levels.
• Compare and contrast sex-limited traits with sex-influenced genes.
• Explain and site examples of multifactoral and polygenetic traits.
Learning Experiences
What activities/instruction will be used to assist students in attaining the Desired Results?
Required Learning Experience:
Lab activities over
Fruit fly crosses
Karyotyping
Pedigree/Family Tree
Coin Flipping and Probability
Chi Squared analysis
Other Learning Experiences:
Pea plant genetics Lab
Rebop Lab
Baby Lab
Genetic Case Studies
Southwest Allen County Schools
Science Curriculum 2011-2017
Human Genetics UNIT 2
Desired Results
What should students know and be able to do? (Include state standards and SACS expectations.)
The student will understand the structure and function of DNA with applications regarding replication,
gene function, gene mutations and cytogenetics.
3.1
Explain the discoveries of the scientists that led to the understanding of the structure and function of
DNA.
3.2
Describe the structure of DNA.
3.3
Describe DNA replication.
3.4
Explain the process and purpose of gene amplification techniques such as PCR.
3.5
Explain the significance of complimentary base pairing.
3.6
Define and distinguish between transcription and translation.
3.7
List the differences between DNA and RNA.
3.8
Define and identify the various types of mutations.
3.9
Explain theory and methods of the study of chromosome variants and their effects on phenotypes
(cytogenetics).
3.10
Describe the following technologies: high resolution chromosome banding, FISH, amniocentesis,
chorionic villus sampling, fetal cell sorting and maternal serum markers.
The student will understand the mechanics of genetic technology.
4.1
Explain the processes and applications of biotechnology including recombinant DNA, transgenic
organisms and gene targeting.
4.2
Explain types, mechanics and sites of gene therapy.
4.3
4.4
Explain economic, ecological and evolutionary concerns and applications of agricultural and
environmental biotechnology.
Explain applications of biotechnology as it relates to human reproduction.
4.5
Explain the mechanics and applications of the human genome project.
Acceptable Evidence
What assessments and products let us know if students have acquired the Desired Results?
Required Acceptable Evidence:
Class Discussion over:
DNA Replication
Transcription
Translation
Chromosomal Abnormalities:
Deletions, insertions, frame shift, inversions
Human Genome Project
Gene Therapy
Genetic Recombinance and Biotechnology
Human Genetic Disorders
Completion of case studies, study guides and review questions
Tests and quizzes over discussions and labs
Other Acceptable Evidence:
Research paper and oral presentation of a Human Genetic disorder
Notebook of current discoveries and developments obtained through newspapers, magazines and the
Internet.
Completion of various supplemental computer programs.
Small group presentations
Class participation
Field trip to Genetics lab
Participation in the Sam Rhine Genetics Conference
Content
What subject matter will be used to help students achieve the Desired Results?
• Explain the discoveries of the scientists that led to the understanding of the structure and function
of DNA.
• Describe the structure of DNA.
• Describe DNA replication.
• Explain the process and purpose of gene amplification techniques such as PCR.
• Explain the significance of complimentary base pairing.
• Define and distinguish between transcription and translation.
• List the differences between DNA and RNA.
• Define and identify the various types of mutations.
• Explain theory and methods of the study of chromosome variants and their effects on phenotypes
(cytogenetics).
• Describe the following technologies: high resolution chromosome banding, FISH, amniocentesis,
chorionic villus sampling, fetal cell sorting and maternal serum markers.
• Explain the processes and applications of biotechnology including recombinant DNA, transgenic
organisms and gene targeting.
• Explain types, mechanics and sites of gene therapy.
• Explain economic, ecological and evolutionary concerns and applications of agricultural and
environmental biotechnology.
• Explain applications of biotechnology as it relates to human reproduction.
• Explain the mechanics and applications of the human genome project.
Learning Experiences
What activities/instruction will be used to assist students in attaining the Desired Results?
Required Learning Experience:
Lab activities over:
Chromosomal Abnormalities:
Deletions, insertions, frame shift, inversions
Protein Synthesis
Other Learning Experiences:
Computer simulations
Genetic Engineering
Bacterial Recombination Lab
Genetic Case Studies