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Gastroenterology
Definition
Gastroenterology is the study of the digestive track and its disorders. The digestive tract is a series of hollow organs joined in a long,
twisting tube from the mouth to the anus, including all other organs that help the body break down and absorb food. The digestive tract
organs consist of the mouth, esophagus, stomach, small intestine, large intestine, rectum and anus. Two solid digestive organs, the
liver and the pancreas, produce digestive juices that reach the intestine through small tubes called ducts. The gallbladder stores the
liver’s digestive juices until they are needed in the intestine.
Role of molecular imaging
Molecular imaging can be used to help diagnose issues related to the gastrointestinal system.

Carbon-14 urea can be used as an aid in diagnosing a stomach infection.

Technetium-99m disofenin or Tc-99m mebrofenin can be used in the diagnosis of acute cholecystitis.

Pyrophosphate can be used to radiolabel Technetium-99m red blood cells to detect sites of gastrointestinal bleeding.

Technetium-99m sulfur colloid can help image areas of functioning reticendothelial cells in the liver, spleen and bone marrow.
Orally it can be used for esophageal transit studies, gastroesophageal reflux scintigraphy, detection of pulmonary aspiration of
gastric contents and evaluation of peritoneo-venous shut patency.
Radiopharmaceutical
Manufacturer
Trade names
Approved indications in adults
(*adult and pediatric use)
Carbon-14 urea
Kimberly-Clark
PYtest
Detection of gastric urease as an aid in the
diagnosis of H.pylori infection in the stomach
Diagnosis of acute cholecystitis as well as to
rule out the occurrence of acute cholecystitis in
suspected patients with right upper quadrant
pain, fever, jaundice, right upper quadrant
tenderness and mass or rebound tenderness,
but not limited to these signs and symptoms.
®
Technetium-99m disofenin
Pharmalucence
Hepatolite
Technetium-99m mebrofenin
Bracco Diagnostics
Pharmalucence
Choletec
As a hepatobiliary imaging agent
Technetium-99m
pyrophosphate
Covidien
Pharmalucence
Technescan™
PYP™
Detection of sites of gastrointestinal bleeding
Technetium-99m red blood
cells
Covidien
UltraTag™
Tc99m-labeled red blood cells are used for:
 Detection of sites of gastrointestinal
bleeding
Technetium-99m sulfur colloid
Pharmalucence
Imaging areas of functioning retriculoendothelial
cells in the liver, spleen and bone marrow*
It is used orally for:
 Esophageal transit studies*
 Gastroesophageal reflux scintigraphy*
 Detection of pulmonary aspiration of
gastric contents*
Aid in the evaluation of peritoneo-venous
(LeVeen) shunt patency
MSDS and package insert information
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