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section 6.6 6F, 6G Meiosis and Genetic Variation Key Concept Independent assortment and crossing over during meiosis result in genetic diversity. Sexual reproduction produces a lot of variety within a species. This VOCABULARY genetic variety comes from the events of meiosis and from the fertilizaRecall Mendel’s law of independent assortment tion of gametes, which is a random process. Recall that humans have 23 described on p. 103. pairs of chromosomes, and that each pair assorts independently from the others. As a result, there are about 8 million different combinations of chromosomes that can be produced during meiosis of one human cell. Suppose a human sperm cell that has one of 8 million different possible combinations fertilizes a human egg cell that has one of 8 million different possible combinations. Since any sperm cell can Crossing Over fertilize any egg, more than 64 trillion possible combinations Crossing over exchanges pieces of can result. DNA between homologous For all sexually reproducing organisms, sexual reproduction chromosomes. results in unique combinations of the two parents’ genes. Therefore, their offspring have unique phenotypes. This variety helps some organisms of a species survive and reproduce in conditions where other organisms of the species cannot. What are two parts of sexual reproduction that produce genetic variation? Crossing over during meiosis increases genetic diversity. Crossing over is a process that occurs during meiosis and also contributes to genetic variation. Crossing over is the exchange* of chromosome pieces between homologous chromosomes. This happens during prophase I of meiosis I. The process is shown in the figure to the right. Crossing over can happen many times—even within the same pair of homologous chromosomes. * Academic Vocabulary exchange to give and receive, or to trade something 108 Holt McDougal Biology 1 wo homologous chromosomes T pair up with each other during prophase I in meiosis. 2 In this position, some chromatids are very close to each other and pieces cross. 3 Some of these pieces break off and reattach to the other homologous chromosome. © Houghton Mifflin Harcourt Publishing Company Sexual reproduction creates unique gene combinations. Recall that a single chromosome has GENETIC LINKAGE many genes, each with its own locus, or A and B are not linked to C and D because they are so far place, on the chromosome. Two genes on apart. Crossing over is likely to occur in the space between genes B and C, thereby separating A and B from C and D. the same chromosome may be close together or far apart. For example, in the A and B are referred to as linked because gene A they would likely be inherited together. figure to the right, genes A and B are close gene B together, but they are both far apart from genes C and D. When crossing over occurs, it is likely that genes A and B will be separated from genes C and D. But it is unlikely that genes A and B will be separated from gene C C and D are referred to as linked because gene D each other—or that C and D will be sepathey would likely be inherited together. rated—because they are so close together. Genes located close together tend to be inherited together, which is called genetic linkage. In the figure above, which genes are likely to be separated by crossing over? 6.6 Vocabulary Check © Houghton Mifflin Harcourt Publishing Company crossing over genetic linkage Mark It Up Go back and highlight each sentence that has a vocabulary word in bold. 1. Draw a picture that shows two chromosomes crossing over. 2. Draw a picture that shows genetic linkage of two genes on a chromosome. 6.6 The Big Picture 3. How is genetic diversity beneficial to a species? 4. How does crossing over contribute to genetic diversity? Interactive Reader 109