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Immuno-Quiz 20.07.2016 Cytokines and chemokines What are cytokines? Cytokines and chemokines Which are the three structural main families of the cytokines? Please give one example for each case. Cytokines and chemokines How do the cytokines act? (characterize their properties to interact) Cytokines and chemokines Mention four general immunological processes in which cytokines are involved. Complement system Explain the three ways which lead to the activation of the complement systems. Complement system Name the three main tasks of the complement system. Complement system What is the function of the complement protein C5b? Complement system Point out the functions of the small complement proteins C3a, C4a and C5a? B-cells and antibodies What are immunoglobulins and how is their basic structure? B-cells and antibodies Which antibody classes (isotypes) are classified and where do they mostly occur? B-cells and antibodies Explain the terms affinity and avidity? Antigen presentation Which cells are involved in the antigen presentation? Antigen presentation Which signals are needed for the activation of T-cells? Innate immunity How does LPS affect macrophages? Describe the signalling cascade! Cytokines and chemokines Mention four general immunological processes in which cytokines are involved. B-cells and antibodies How and where does the B-cell maturation take place? T-cells How does the T-cell-mediated immunity take place? Innate immunity What are PAMPs and PRRs? Name one example each! Innate immunity Name the humoral and cellular factors of the innate immunity. Group: T-cells Cytokines and chemokines Name at least four cytokines, which are secreted by activated macrophages. Antigen presentation Why is antigen presentation necessary? Antigen presentation How large are the bound peptide fragments which can bind MHC-I or MHC-II? Innate immunity Describe differences between innate immunity and acquired immunity. Cytokines and chemokines What are pleiotropic cytokines? Name one example. B-cells and antibodies Describe the differences between the various immunoglobulins. Antigen presentation Which MHC-complexes activate which T-cells? Cytokines and chemokines During cell contact with endotoxins a signalling cascade is triggered, leading to the release of cytokines. On which receptor binds thereby the LPS-LBP-CD14-complex? Innate immunity Describe the advantages of the innate immune response B-cells and antibodies What is described as „Immunoglobulin-superfamily“? Antigen presentation How differ MHC I- and MHC IImolecules? Antigen presentation What is the purpose of the invariant chain and the CLIP-protein on the MHCII-molecules in the ER? T-cells Which maturation phases exist for the T-cells and where does the maturation take place? T-cells What kind of T-cells are present in the organism? B-Zellen und Antikörper What is the difference between neutralisation and opsonisation?