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From: X-Linked High Myopia Associated With Cone Dysfunction Arch Ophthalmol. 2004;122(6):897-908. doi:10.1001/archopht.122.6.897 Figure Legend: Limited version of a branch ofthe original Bornholm eye disease pedigree with haplotypes of chromosome Xq27-q28markers. Symbols are explained in the legend to Figure 1. Individual 3 hasonly deuteranopia, which is unrelated to Bornholm eye disease (see the lastparagraph of the "Molecular Structure of Color Vision Genes" subsection ofthe "Results" section). Date of download: 6/10/2017 Copyright © 2004 American Medical Association. All rights reserved. From: X-Linked High Myopia Associated With Cone Dysfunction Arch Ophthalmol. 2004;122(6):897-908. doi:10.1001/archopht.122.6.897 Figure Legend: Comparative electroretinogramresponses between an affected Minnesota family participant (person 24) (someblink artifact), obligate carrier (person 33), and an unrelated normal malecontrol. A, Mixed rod and cone responses obtained with flashes of maximumintensity (0 dB) show a subnormal b-wave amplitude in the affected participant,but not in the carrier or control. B, Lowintensity (24-dB) dark-adapted scotopicrod responses showed no definite abnormality among the participants. C, Oscillatorypotentials, single white-flash, dark-adapted (scotopic responses recordedwith the use of high-intensity 0-dB Copyright © 2004rod) American Medical Date of download: 6/10/2017 stimulation showed no definite abnormalityamong Association. the participants. D, Maximum-flash (0-dB), photopic cone responses showmarked All rights reserved. reduction of both a- and b-wave amplitudes in the affected participant,compared with normal amplitudes for the carrier and control From: X-Linked High Myopia Associated With Cone Dysfunction Arch Ophthalmol. 2004;122(6):897-908. doi:10.1001/archopht.122.6.897 Figure Legend: Schematic representation of theX chromosome and the Xq27/Xq28 region. Marker order and genetic distanceswere determined by reference to the National Center for Biotechnology Informationgenetic map, the Weber 9 Set, and the Généthon genetic map.The position of the markers relative to the chromosomal bands are approximate.Opsin 1 indicates red-green cone pigment gene array; cM, centimorgan. Date of download: 6/10/2017 Copyright © 2004 American Medical Association. All rights reserved. From: X-Linked High Myopia Associated With Cone Dysfunction Arch Ophthalmol. 2004;122(6):897-908. doi:10.1001/archopht.122.6.897 Figure Legend: Pedigree and haplotypes of a Minnesota6-generation family with X-linked high myopia and protanopia. Circles andsquares denote females and males, respectively; solid symbols denote affectedindividuals; and symbols with slashes denote deceased individuals. Obligatefemale carriers are denoted with a circle containing a dot. Unknown phenotypestatus is denoted with a circle or square containing a question mark. Eachindividual studied (plus sign) has alleles shown for X chromosome markersin descending marker order from the telomere of the p arm to the telomereof the©q2004 arm.American Haplotypes were constructed on the basis of the minimum Copyright Medical Date of download: 6/10/2017 numberof recombinations between markers. The chromosome assumed to carry Association. All rights reserved. the diseaseallele is blackened. Only essential matings are shown; nonparticipating familymembers are not shown. Haplotype analysis indicates crossovers in individuals24 and From: X-Linked High Myopia Associated With Cone Dysfunction Arch Ophthalmol. 2004;122(6):897-908. doi:10.1001/archopht.122.6.897 Figure Legend: A, Genomic structure of the normalhuman red and green pigment array. The red and green pigment genes span 15.2kilobase (kb) and 13.3 kb, respectively, with a 24.0-kb separation betweenthese 2 genes. Additional copies of the green pigment gene arranged in tandemat 24.0-kb intervals are found in 60% of the general white population. B,Relationship of the position of the 3′-red-green-5′ (RG) hybridgene in the visual-pigment gene array found in the Minnesota (MN) family.Hybrids can occur because of the high degree of homology of these 2 genes(98%) (see the first paragraph the "Molecular Structure of Color VisionGenes" subsection of the Copyright ©of2004 American Medical Date of download: "Results" section).6/10/2017 Individuals have a variable numberof green pigment genes. Association. All rights reserved.This family has 3 additional normal green pigmentgenes. C, Genomic structure of the human red and green pigment array fromDNA samples of individuals 26 and 28 with